Comprehensive medication guide to Amphetamine XR including estimated pricing, availability information, side effects, and how to find it in stock at your local pharmacy.
Estimated Insurance Pricing
Most insurance plans require prior authorization and step therapy; commercially insured patients may pay as little as $20 per fill with the Tris Pharma Savings Card.
Estimated Cash Pricing
Amphetamine XR brand formulations cost $170–$735 per month without insurance, depending on the specific product and dose.
Medfinder Findability Score
35/100
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Amphetamine XR refers to extended-release formulations of amphetamine used to treat Attention Deficit Hyperactivity Disorder (ADHD) in patients aged 6 years and older. Brand-name products include Dyanavel XR (an extended-release oral suspension), Adzenys XR-ODT (an orally disintegrating tablet), and Adzenys ER (an oral suspension). These medications provide once-daily dosing and are designed to release amphetamine gradually throughout the day, helping improve attention, focus, and impulse control. Evekeo is a related immediate-release amphetamine tablet also used for ADHD.
Amphetamine works by increasing the release and blocking the reuptake of two key neurotransmitters in the brain: and . It also inhibits monoamine oxidase. These combined actions raise the concentration of stimulatory neurotransmitters in the synaptic cleft, which improves attention, focus, and impulse control in people with ADHD. The extended-release formulations use special delivery systems to provide an initial dose followed by a gradual release over several hours, maintaining therapeutic levels throughout the day.
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![How to Find a Doctor Who Can Prescribe Amphetamine/Dextroamphetamine XR Near You [2026 Guide]](/_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2Fvur4atr4%2Fproduction%2F1e90ffe29163750b91598de2353c41cebce25eca-1024x1024.png%3Frect%3D0%2C256%2C1024%2C512%26w%3D400%26h%3D200%26auto%3Dformat&w=828&q=75)
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Dyanavel XR (extended-release oral suspension) — suspension
2.5 mg/mL
Adzenys XR-ODT (extended-release orally disintegrating tablet) — tablet
3.1 mg, 6.3 mg, 9.4 mg, 12.5 mg, 15.7 mg, 18.8 mg
Adzenys ER (extended-release oral suspension) — suspension
1.25 mg/mL
Evekeo (immediate-release tablet) — tablet
5 mg, 10 mg
Amphetamine XR scores a 35 out of 100 on our findability scale, meaning it is currently very difficult to find in stock. The ongoing ADHD stimulant shortage that began in October 2022 continues to affect amphetamine-based products including Dyanavel XR, Adzenys XR-ODT, and Adzenys ER. While the DEA raised production quotas by up to 25% in October 2025 and again in January 2026, demand still outpaces supply. Availability varies significantly by location and formulation.
Amphetamine XR can be prescribed by a range of healthcare providers, including:
Because Amphetamine XR is a Schedule II controlled substance, all prescribers must have DEA authorization. Telehealth prescribing is available but subject to state and federal regulations for controlled substances.
Yes. Amphetamine XR is classified as a Schedule II (C-II) controlled substance by the DEA. This is the highest schedule for medications with accepted medical use, reflecting its high potential for abuse and dependence. Prescriptions cannot be called in — they must be written (or e-prescribed) and cannot have refills. A new prescription is required each time. The FDA boxed warning states that CNS stimulants including amphetamine have a high potential for abuse and dependence.
Serious side effects can include sudden cardiac events, increased blood pressure and heart rate, psychiatric reactions (psychosis, mania, aggression), peripheral vasculopathy (Raynaud's phenomenon), serotonin syndrome, seizures, and long-term growth suppression in children.
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Adderall XR (Amphetamine/Dextroamphetamine Mixed Salts XR)
The most commonly prescribed amphetamine-based ADHD medication. Generic available at low cost ($17–$50/month).
Vyvanse (Lisdexamfetamine)
A prodrug of dextroamphetamine with lower abuse potential and once-daily dosing. Generic now available.
Concerta (Methylphenidate ER)
A different stimulant class (methylphenidate). Good option for patients who don't tolerate amphetamines.
Mydayis (Mixed Amphetamine Salts Triple-Bead)
Ultra-long-acting amphetamine lasting up to 16 hours for patients needing extended coverage.
Prefer Amphetamine XR? We can find it.
MAOIs
moderateContraindicated within 14 days due to risk of hypertensive crisis and serotonin syndrome
Serotonergic drugs
moderate(SSRIs, SNRIs, triptans, tricyclic antidepressants, fentanyl, lithium, tramadol, buspirone, St. John's Wort) — Risk of serotonin syndrome
CYP2D6 inhibitors
moderate(e.g., quinidine, ritonavir) — May increase amphetamine exposure
Urinary acidifying agents
moderate(ascorbic acid, ammonium chloride) — Decrease amphetamine levels
Urinary alkalinizing agents
moderate(sodium bicarbonate, acetazolamide) — Increase amphetamine levels
Antihypertensives
moderateAmphetamine may reduce their effectiveness
Acidic foods/beverages
moderate(citrus juice, vitamin C) — May reduce absorption
Amphetamine XR remains an important treatment option for ADHD, but the ongoing stimulant shortage makes it challenging to find in stock. With a findability score of just 35 out of 100, patients may need to check multiple pharmacies or consider alternative formulations. Brand products like Dyanavel XR and Adzenys XR-ODT cost $170–$735 per month without insurance, but the Tris Pharma Savings Card can reduce costs to as low as $20 per fill for commercially insured patients. If you're struggling to find Amphetamine XR, use Medfinder to search pharmacies near you, talk to your prescriber about alternatives like generic Adderall XR or Vyvanse, and check NeedyMeds.org for additional assistance programs.
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