Amphetamine/Dextroamphetamine XR: A Complete Overview

Amphetamine/Dextroamphetamine XR is an extended-release stimulant medication used to treat attention deficit hyperactivity disorder (ADHD). It's the generic version of Adderall XR and is one of the most widely prescribed ADHD medications in the United States.

The "XR" stands for extended-release, meaning the capsule is designed to release medication gradually over the course of the day — typically providing up to 12 hours of symptom control from a single morning dose.

What Is Amphetamine/Dextroamphetamine XR?

Amphetamine/Dextroamphetamine XR is a central nervous system (CNS) stimulant that belongs to the amphetamine drug class. It's classified as a Schedule II controlled substance by the DEA, meaning it has a high potential for abuse and requires a prescription.

Each capsule contains a mixture of four amphetamine salts:

• Dextroamphetamine sulfate
• Amphetamine sulfate
• Dextroamphetamine saccharate
• Amphetamine aspartate monohydrate

These salts are combined in a 3.1-to-1 ratio of dextroamphetamine to levoamphetamine. The capsule contains two types of drug-releasing beads: one that releases medication immediately and one that releases it several hours later, creating a smooth, extended effect.

For a detailed explanation of how the medication works in your brain, see How Does Amphetamine/Dextroamphetamine XR Work?

What Is It Used For?

Amphetamine/Dextroamphetamine XR is FDA-approved to treat ADHD in patients aged 6 and older. This includes children, adolescents, and adults.

ADHD is a neurodevelopmental disorder characterized by:

• Difficulty paying attention or staying focused
• Hyperactivity (excessive movement, fidgeting)
• Impulsivity (acting without thinking, interrupting others)

The medication helps by increasing levels of dopamine and norepinephrine in the brain — two neurotransmitters that play key roles in attention, focus, and impulse control.

While the immediate-release form (Adderall) is also approved for narcolepsy, the XR version is specifically indicated for ADHD.

How Is It Taken?

Amphetamine/Dextroamphetamine XR is taken once daily in the morning, upon waking. Key details:

• Swallow the capsule whole with water, or open it and sprinkle the beads on applesauce (swallow without chewing the beads).
• Do not crush or chew the beads — this would release the entire dose at once and defeat the extended-release design.
• Take it with or without food. High-fat meals may delay absorption slightly but don't reduce effectiveness.
• Do not take in the afternoon or evening — it can cause insomnia.

Typical Dosing

• Children (ages 6–12): Start at 10 mg once daily. May be increased by 5–10 mg weekly. Maximum: 30 mg/day.
• Adolescents (ages 13–17): Start at 10 mg once daily. Maximum: 30 mg/day.
• Adults: Start at 20 mg once daily. Maximum: varies, but typically up to 30 mg/day for the standard XR formulation.

Your doctor will start at a low dose and increase gradually based on how you respond and any side effects you experience.

Available Strengths

Extended-release capsules come in: 5 mg, 10 mg, 15 mg, 20 mg, 25 mg, and 30 mg.

Who Should Not Take It?

Amphetamine/Dextroamphetamine XR is not safe for everyone. You should not take it if you have:

• A known allergy to amphetamine products
• Used an MAO inhibitor within the past 14 days (risk of hypertensive crisis)
• Advanced hardening of the arteries (arteriosclerosis)
• Symptomatic cardiovascular disease
• Moderate to severe high blood pressure
• Hyperthyroidism (overactive thyroid)
• Glaucoma
• A history of drug abuse
• An agitated state

It's also not recommended during pregnancy or breastfeeding. Talk to your doctor about the risks if this applies to you.

For a full list of medications to avoid, see our guide to Amphetamine/Dextroamphetamine XR drug interactions.

How Much Does It Cost?

Cost is one of the biggest concerns for patients, especially during the current shortage. Here's what you can expect to pay in 2026:

• Brand-name Adderall XR: $250 to $450 per month (30 capsules) without insurance
• Generic Amphetamine/Dextroamphetamine XR (retail): $200 to $350 per month without insurance or coupons
• Generic with discount coupons: $28 to $80 per month through services like SingleCare or GoodRx
• With insurance: Most commercial and Medicare plans cover generic Amphetamine/Dextroamphetamine XR with a copay, often $10 to $50 per month

Discount coupons can dramatically reduce the price. For a complete breakdown of savings options, see How to Save Money on Amphetamine/Dextroamphetamine XR.

What About the Shortage?

As of early 2026, Amphetamine/Dextroamphetamine XR remains in active shortage. Certain strengths — particularly 15 mg, 25 mg, and 30 mg — are intermittently unavailable at many pharmacies. If you're having trouble finding your medication, Medfinder can help you locate pharmacies with stock near you.

Final Thoughts

Amphetamine/Dextroamphetamine XR is an effective, well-studied medication that helps millions of people manage ADHD symptoms. Understanding what it is, how to take it properly, and what it costs puts you in a better position to work with your doctor and get the most from your treatment.

If you need help finding Amphetamine/Dextroamphetamine XR at a pharmacy near you, try Medfinder — it's free and shows real-time availability.