Amphetamine XR Shortage Update: What Patients Need to Know in 2026

The Amphetamine XR Shortage in 2026: Where Things Stand

If you rely on Amphetamine XR to manage your ADHD, the past few years have been a frustrating experience. The nationwide shortage of amphetamine-based medications — which started in October 2022 — continues into 2026, leaving patients struggling to fill prescriptions for formulations like Dyanavel XR, Adzenys XR-ODT, and Adzenys ER.

In this update, we'll cover the current state of the shortage, what's changed recently, how much Amphetamine XR costs in 2026, and what you can do to find your medication.

Is Amphetamine XR Still in Shortage?

Yes. As of early 2026, amphetamine-based ADHD medications — including extended-release formulations — remain in shortage across the United States. The FDA's drug shortage database continues to list amphetamine products as having limited availability.

While conditions have improved slightly compared to the worst months of 2023 and 2024, the shortage is far from over. Patients in many regions still report difficulty finding Amphetamine XR at their local pharmacies.

Why Is It Still Hard to Find?

The shortage stems from several ongoing factors:

• DEA production quotas: The DEA controls how much amphetamine can be manufactured each year. While they raised quotas by up to 25% in October 2025 and set new 2026 production limits in January 2026, the increases have been described as insufficient to meet actual demand.
• Rising demand: ADHD diagnoses continue to climb, with the FDA estimating a 6% year-over-year increase in demand for amphetamine products from 2023 to 2024. Telehealth-driven prescribing has further expanded the patient population.
• Brand-only formulations: Dyanavel XR and Adzenys XR-ODT have no generic equivalents and are made by a single manufacturer (Tris Pharma). Any supply disruption has an outsized effect.
• Distribution challenges: Even when supply exists, it isn't always distributed evenly across regions, leaving some areas worse off than others.

For a deeper dive into the causes, read why Amphetamine XR is so hard to find.

How Much Does Amphetamine XR Cost in 2026?

Amphetamine XR is a brand-name-only medication, and costs reflect that:

• Dyanavel XR: Approximately $440–$590 per month without insurance
• Adzenys XR-ODT: Approximately $330–$735 per month without insurance

These prices are significantly higher than generic alternatives like Adderall XR (mixed amphetamine salts), which can be found for as low as $17–$50 per month with a discount coupon.

If cost is a concern, the Tris Pharma Savings Card can help. Eligible commercially insured patients may pay as little as $20 per prescription, and cash-paying patients may get their first fill for as little as $50. Learn more in our guide to saving money on Amphetamine XR.

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Are There New Options in 2026?

While no new generic versions of Dyanavel XR or Adzenys XR-ODT have launched, there are developments worth noting:

• Higher DEA quotas: The increased production limits for 2026 should gradually improve supply, though the effects may take months to fully materialize.
• Generic Vyvanse: Generic lisdexamfetamine became available in 2023, adding another affordable extended-release amphetamine-based option to the market.
• Telehealth prescribing: More providers are offering ADHD management via telehealth, making it easier to work with your doctor on medication adjustments without an in-person visit.

How to Find Amphetamine XR in Stock

Here are the most effective strategies:

1. Use Medfinder — Search for real-time pharmacy availability near your zip code.
2. Check independent pharmacies — They often have better controlled-substance availability than large chains.
3. Time your refills — Fill early in the month and call pharmacies after their weekly controlled substance deliveries.
4. Ask your doctor about alternatives — If Amphetamine XR is unavailable, consider proven alternatives like Adderall XR, Vyvanse, or Concerta.

For more detailed tips, see our guide on how to find Amphetamine XR in stock near you.

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Final Thoughts

The Amphetamine XR shortage is now more than three years old, and while there are signs of improvement, patients in 2026 still face real challenges getting their prescriptions filled. Staying proactive — using availability tools, working with your prescriber, and knowing your options — is the best way to manage through the shortage.

Bookmark this page for future updates, and use Medfinder to stay on top of availability in your area.