When Your Prescription Can't Be Filled

You've done everything right. You have a valid prescription for Amphetamine XR. You've called multiple pharmacies. You've checked online. And you still can't find it in stock.

If this is your situation, you're not alone. The ongoing ADHD medication shortage has left millions of patients scrambling to fill their prescriptions. But going without treatment isn't an option — especially when effective alternatives exist.

In this guide, we'll walk you through what Amphetamine XR is, how it works, and four real alternatives you can discuss with your doctor.

What Is Amphetamine XR?

Amphetamine XR is the extended-release form of amphetamine, a Schedule II CNS stimulant used to treat ADHD in patients aged 6 and older. Brand-name versions include:

• Dyanavel XR — extended-release liquid suspension
• Adzenys XR-ODT — extended-release orally disintegrating tablet
• Adzenys ER — extended-release oral suspension

These formulations are designed to release medication gradually throughout the day, providing steady symptom control with just one morning dose. For a deeper look at the medication, see What Is Amphetamine XR?

How Does Amphetamine XR Work?

Amphetamine works by increasing the release and blocking the reuptake of norepinephrine and dopamine — two neurotransmitters that play key roles in attention, focus, and impulse control. By boosting the concentration of these chemicals in the brain, amphetamine helps reduce the core symptoms of ADHD.

The extended-release mechanism releases a portion of the dose immediately and the rest gradually over 8 to 12 hours. For more detail, check out How Does Amphetamine XR Work?

4 Alternatives to Amphetamine XR

If you can't find Amphetamine XR, here are four alternatives your prescriber may recommend. All are FDA-approved for ADHD, and most are more widely available.

1. Adderall XR (Generic: Amphetamine/Dextroamphetamine Mixed Salts XR)

Adderall XR is the most commonly prescribed extended-release amphetamine medication for ADHD. It contains a mixture of amphetamine and dextroamphetamine salts and is available as a generic, making it significantly more affordable and easier to find than brand-only formulations.

• How it's taken: Once-daily capsule, swallowed whole or opened and sprinkled on applesauce
• Duration: 10–12 hours
• Generic price: As low as $17–$50/month with a coupon
• Best for: Patients who can swallow capsules and want a widely available, affordable amphetamine option

Important: Adderall XR is not identical to Dyanavel XR or Adzenys XR-ODT. The active ingredients are different (mixed salts vs. amphetamine base), so dosing does not convert mg-for-mg. Your doctor will calculate the appropriate dose.

2. Vyvanse (Generic: Lisdexamfetamine)

Vyvanse is a prodrug of dextroamphetamine, meaning it must be converted by your body into its active form. This design gives it a smoother onset and is associated with lower abuse potential compared to traditional amphetamines.

• How it's taken: Once-daily capsule or chewable tablet
• Duration: Up to 14 hours
• Generic price: Starting around $30–$70/month with a coupon (generic became available in 2023)
• Best for: Patients who need long-lasting coverage or who have a history of medication misuse concerns

3. Concerta (Generic: Methylphenidate ER)

Concerta uses a different stimulant — methylphenidate — rather than amphetamine. It's a good option for patients who don't respond well to amphetamines or experience too many side effects.

• How it's taken: Once-daily tablet (must be swallowed whole)
• Duration: Up to 12 hours
• Generic price: As low as $20–$60/month with a coupon
• Best for: Patients who haven't tolerated amphetamine-based medications or who want to try a different stimulant class

4. Mydayis (Mixed Amphetamine Salts, Triple-Bead)

Mydayis is an ultra-long-acting amphetamine formulation designed to provide up to 16 hours of symptom control. It uses a triple-bead technology to release medication in three stages throughout the day.

• How it's taken: Once-daily capsule
• Duration: Up to 16 hours
• Price: Brand-only; typically $300–$400/month without insurance
• Best for: Adults and adolescents (13+) who need extended coverage into the evening hours

How to Talk to Your Doctor About Switching

If you need to switch from Amphetamine XR to an alternative, here are some questions to bring to your appointment:

• Which alternative is most similar to my current medication?
• What dose would be equivalent?
• Will my insurance cover the new medication?
• Are there any side effects I should watch for during the transition?

Your prescriber can help you find the right fit based on your treatment history, insurance coverage, and personal preferences. For help finding a provider, see how to find a doctor who can prescribe Amphetamine XR.

Final Thoughts

Not being able to fill your Amphetamine XR prescription is stressful, but you have options. Adderall XR, Vyvanse, Concerta, and Mydayis are all legitimate alternatives with strong clinical evidence for treating ADHD.

Start by checking Medfinder to see if Amphetamine XR is available near you. If it's not, talk to your doctor about which alternative makes the most sense for your situation.

For more information on the current shortage, read our Amphetamine XR shortage update for 2026.