When You Can't Find Your ADHD Medication, Alternatives Exist

If you've been trying to fill your Amphetamine/Dextroamphetamine XR prescription and keep running into empty shelves, you're dealing with a problem that has affected millions of patients since the shortage began in 2022. While the supply is improving in 2026, many patients still can't reliably find their usual medication.

The good news: there are several effective alternatives. Switching medications isn't ideal, but going without treatment is worse. In this guide, we'll explain what Amphetamine/Dextroamphetamine XR does, how it works, and which alternatives your doctor might recommend.

Important: Never switch medications on your own. Always talk to your prescriber before making any changes to your ADHD treatment.

What Is Amphetamine/Dextroamphetamine XR?

Amphetamine/Dextroamphetamine XR is the generic version of Adderall XR, an extended-release stimulant prescribed for ADHD. It contains a mixture of four amphetamine salts that work in two phases: about half the dose releases immediately, and the other half releases about four hours later. This provides symptom relief for up to 12 hours from a single morning dose.

It's available in capsule strengths of 5 mg, 10 mg, 15 mg, 20 mg, 25 mg, and 30 mg, and it's classified as a DEA Schedule II controlled substance.

How Does It Work?

Amphetamine/Dextroamphetamine XR works by increasing the levels of dopamine and norepinephrine in the brain. These neurotransmitters play key roles in attention, focus, and impulse control. By blocking their reuptake and promoting their release, the medication helps improve concentration and reduce hyperactive or impulsive behavior in people with ADHD.

For a more detailed explanation, see our post on how Amphetamine/Dextroamphetamine XR works.

Alternative 1: Vyvanse (Lisdexamfetamine)

Vyvanse is one of the most commonly recommended alternatives. It's a prodrug, meaning it's inactive until your body converts it into dextroamphetamine after you swallow it. This design provides a smooth, long-lasting effect (up to 14 hours) and has a lower potential for misuse compared to traditional amphetamine formulations.

• Available as: Capsules (10 mg to 70 mg) and chewable tablets
• Generic available: Yes — generic lisdexamfetamine became available in 2023
• Typical cost: $30-$80/month for generic with discount coupons
• Good for: Patients who want long-acting coverage with a smoother onset

Vyvanse treats both ADHD and binge eating disorder in adults.

Alternative 2: Concerta (Methylphenidate ER)

Concerta uses a different stimulant — methylphenidate — rather than amphetamine. It works through a similar mechanism (increasing dopamine and norepinephrine) but has a different chemical structure. Some patients who don't respond well to amphetamines do better on methylphenidate, and vice versa.

• Available as: Extended-release tablets (18 mg, 27 mg, 36 mg, 54 mg)
• Generic available: Yes
• Typical cost: $30-$90/month for generic with coupons
• Good for: Patients who experience too many side effects from amphetamines or need a different stimulant class

Alternative 3: Mydayis (Mixed Amphetamine Salts, Triple-Bead)

Mydayis contains the same amphetamine salts as Adderall XR but uses a triple-bead technology that provides coverage for up to 16 hours — longer than Adderall XR's 12-hour duration. It was designed for patients who need symptom control into the evening hours.

• Available as: Capsules (12.5 mg, 25 mg, 37.5 mg, 50 mg)
• Generic available: Not yet
• Typical cost: $300-$400/month (brand only); manufacturer coupons may help
• Good for: Adults and adolescents (13+) who need longer coverage than standard XR formulations

Alternative 4: Dexedrine Spansules (Dextroamphetamine ER)

Dexedrine Spansules contain pure dextroamphetamine in an extended-release capsule. Since Amphetamine/Dextroamphetamine XR already contains about 75% dextroamphetamine, the transition can be relatively straightforward for many patients.

• Available as: Extended-release capsules (5 mg, 10 mg, 15 mg)
• Generic available: Yes
• Typical cost: $25-$70/month for generic with coupons
• Good for: Patients who respond well to the dextroamphetamine component specifically

How to Talk to Your Doctor About Switching

If you're considering an alternative, here are some tips for the conversation with your prescriber:

• Explain the situation: Let your doctor know you've been unable to find your medication and for how long.
• Share what's worked: Tell them what you like about Amphetamine/Dextroamphetamine XR (e.g., duration, side effect profile) so they can pick a close match.
• Ask about transitions: Some switches are straightforward; others may require dose adjustments or a brief washout period.
• Discuss cost: Some alternatives are more expensive than generic Amphetamine/Dextroamphetamine XR. Ask about insurance coverage and discount options.

For help finding a prescriber, see our guide on how to find a doctor who can prescribe Amphetamine/Dextroamphetamine XR near you.

Before You Switch: Try Finding Your Medication First

Switching medications should be a last resort. Before making a change, try these steps:

1. Search Medfinder to check pharmacy stock near you
2. Call independent and compounding pharmacies
3. Ask about different strengths that may be available

For more tips, read our post on how to find Amphetamine/Dextroamphetamine XR in stock near you.

Final Thoughts

Not being able to fill your ADHD prescription is stressful, but you have options. Vyvanse, Concerta, Mydayis, and Dexedrine Spansules are all legitimate alternatives that can help you stay on track while the Amphetamine/Dextroamphetamine XR shortage continues to improve. Work with your doctor to find the best fit, and use Medfinder to keep searching for your preferred medication in the meantime.