Amphetamine XR is an extended-release central nervous system (CNS) stimulant used to treat attention deficit hyperactivity disorder (ADHD) in patients aged 6 and older.

What Is Amphetamine XR?

Amphetamine XR refers to extended-release formulations of amphetamine, a stimulant medication that has been used to treat ADHD for decades. Unlike immediate-release versions that need to be taken multiple times a day, Amphetamine XR is designed to release medication gradually throughout the day with a single morning dose.

The most common brand names for Amphetamine XR include:

• Dyanavel XR — An extended-release oral suspension (liquid) made by Tris Pharma, available at 2.5 mg/mL.
• Adzenys XR-ODT — An extended-release orally disintegrating tablet, available in strengths from 3.1 mg to 18.8 mg.
• Adzenys ER — An extended-release oral suspension at 1.25 mg/mL.

These formulations contain amphetamine (not a mixed salt like Adderall). They are all Schedule II controlled substances, meaning they have a recognized medical use but also carry a risk of abuse and dependence.

What Is Amphetamine XR Used For?

Amphetamine XR is FDA-approved to treat ADHD in patients aged 6 years and older. ADHD is a neurodevelopmental disorder that affects focus, attention, impulse control, and sometimes hyperactivity.

Amphetamine XR may also be used off-label for conditions like narcolepsy, though this is less common with these specific formulations. Your doctor can help determine if Amphetamine XR is the right choice for your situation.

To understand how this medication works at a deeper level, see our guide on how Amphetamine XR works.

How Is Amphetamine XR Taken?

Amphetamine XR is taken once daily in the morning, with or without food. The specific instructions depend on which formulation you're using:

• Adzenys XR-ODT — Place the tablet on your tongue and let it dissolve. Do not chew. It can be taken without water.
• Dyanavel XR suspension — Shake the bottle well before each use. Use the dosing syringe provided — do not estimate with a household spoon.

Important: Do not substitute one Amphetamine XR formulation for another on a milligram-per-milligram basis. The different formulations are not interchangeable.

Avoid taking Amphetamine XR in the afternoon or evening, as it can cause insomnia.

Typical Dosing

• Children (6–12 years): Starting dose is typically 6.3 mg once daily (Adzenys XR-ODT), with a maximum of 18.8 mg/day.
• Adolescents (13–17 years): Starting dose is 6.3 mg once daily, maximum 12.5 mg/day.
• Adults: Starting dose is 12.5 mg once daily, maximum 18.8 mg/day.
• Dyanavel XR: Children start at 2.5–5 mg once daily, with a maximum of 20 mg/day.

Your doctor will start you on the lowest effective dose and adjust gradually based on your response and tolerability.

Who Should Not Take Amphetamine XR?

Amphetamine XR is not right for everyone. You should not take it if you have:

• A known allergy to amphetamine or any ingredients in the formulation
• Used an MAOI (monoamine oxidase inhibitor) within the past 14 days
• Advanced arteriosclerosis or symptomatic cardiovascular disease
• Moderate to severe hypertension (high blood pressure)
• Hyperthyroidism
• Glaucoma
• A history of drug abuse
• Agitated states or severe anxiety

Before starting Amphetamine XR, tell your doctor about all medications you take, including over-the-counter drugs and supplements. Some drug interactions can be dangerous.

How Much Does Amphetamine XR Cost?

Brand-name Amphetamine XR is expensive. Without insurance, you can expect to pay:

• $170 to $735 per month depending on the formulation and dose

There is currently no generic available for Dyanavel XR or Adzenys XR-ODT. However, generic alternatives in the amphetamine class are much more affordable:

• Generic amphetamine sulfate IR tablets: $26–$50/month
• Generic Adderall XR (mixed amphetamine salts ER): $17–$50/month

Insurance coverage for brand Amphetamine XR varies widely. Many plans require prior authorization or step therapy (trying a generic first). If you're struggling with cost, check out our guide to saving money on Amphetamine XR.

The Tris Pharma Savings Card can bring the cost down to as little as $20 for commercially insured patients or $50 for the first cash-pay prescription. Visit coupon.trisadhd.com for details.

Final Thoughts

Amphetamine XR is an effective, once-daily treatment for ADHD that comes in unique formulations — a liquid suspension and an orally disintegrating tablet — that may be helpful for patients who have trouble swallowing capsules or pills.

If you're considering Amphetamine XR, talk to your doctor about whether it's the right fit for you. If you already have a prescription, Medfinder can help you find it in stock near you. And if availability is a problem, explore alternative ADHD medications your doctor might recommend.