Comprehensive medication guide to Adzenys including estimated pricing, availability information, side effects, and how to find it in stock at your local pharmacy.
Estimated Insurance Pricing
$50–$100+/month (Tier 3–4; prior auth typically required; not covered by most plans)
Estimated Cash Pricing
$113–$655/month with GoodRx (brand only, no generic available)
Medfinder Findability Score
35/100
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Adzenys XR-ODT is a prescription stimulant medication used to treat ADHD in children (ages 6+) and adults. It contains amphetamine (the same class of active ingredient as Adderall) in a unique orally disintegrating tablet (ODT) format that dissolves on the tongue without water.
Manufactured by Neos Therapeutics (now Ayala Pharmaceuticals), Adzenys was FDA-approved in 2016. It uses XR-ODT technology to deliver extended-release amphetamine in a convenient dissolvable format — the only ADHD stimulant available as an orally disintegrating tablet.
Many patients report that Adzenys has better tolerability than Adderall or Adderall XR, possibly due to its unique absorption profile. There is currently no generic version available.
Having trouble finding Adzenys? Medfinder helps you locate pharmacies with your medication in stock.
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Adzenys contains amphetamine (a combination of d-amphetamine and l-amphetamine), the same active ingredient class as Adderall. It works by increasing the release and blocking the reuptake of dopamine and norepinephrine in the brain.
The XR-ODT formulation uses a proprietary microparticle delivery system. When the tablet dissolves on the tongue, it releases microparticles that are swallowed with saliva. These microparticles contain both immediate-release and delayed-release components, providing approximately 10–12 hours of symptom coverage.
Effects typically begin within 1–2 hours of dosing.
3.1 mg
6.3 mg
9.4 mg
12.5 mg
15.7 mg
18.8 mg
Adzenys XR-ODT (amphetamine extended-release orally disintegrating tablet) is a specialized ADHD medication that combines extended-release technology with an orally disintegrating tablet format. We've assigned it a findability score of 35 out of 100, meaning patients should expect significant difficulty locating this medication.
Adzenys faces a unique combination of supply challenges. It requires specialized manufacturing that combines two complex pharmaceutical technologies — extended-release and orally disintegrating tablets. Very few facilities can produce it, limiting production capacity. Additionally, there is no generic version available, meaning only the brand-name product exists.
Adzenys is not covered by most Medicare and insurance plans, which limits pharmacy demand and means many pharmacies don't routinely stock it. The high cash price ($655+ retail) further reduces the patient population, creating a smaller market that makes it less economically attractive for pharmacies to carry.
As a Schedule II controlled substance, Adzenys is also subject to DEA production quotas and all the supply chain constraints that affect other amphetamine-based medications.
Patients may need to call 5–15+ pharmacies or work with a specialty pharmacy to find Adzenys. The manufacturer offers a coupon program that can significantly reduce out-of-pocket costs.
Medfinder can help you find Adzenys in stock near you.
Adzenys is a Schedule II controlled substance. Psychiatrists, PCPs, pediatricians, neurologists, psychiatric NPs, and PAs can all prescribe it. Telemedicine waivers remain in effect through 2026.
Because Adzenys is a specialized formulation, not all providers may be familiar with it. Psychiatric specialists and ADHD-focused providers are most likely to prescribe it.
Medfinder helps you find pharmacies with availability.
Yes, Adzenys is a Schedule II controlled substance. No automatic refills, no phone-in prescriptions, early refill restrictions, DEA production quotas, and pharmacy stocking limits all apply.
Medfinder helps you find a pharmacy with stock before your doctor sends the prescription.
Some patients report better tolerability with Adzenys compared to other amphetamine formulations, though individual responses vary.
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Adderall XR
Mixed amphetamine salts, 8–10 hours. More widely available but also subject to shortage.
Vyvanse (lisdexamfetamine)
Prodrug, 10–14 hours. Generic available.
Mydayis
Up to 16 hours of coverage. Generic available.
Dynavel XR
Liquid amphetamine ER, ~13 hours. Good option if the liquid format works for you.
Dexedrine Spansule
Extended-release dextroamphetamine capsules.
Cotempla XR-ODT
Also an orally disintegrating tablet (methylphenidate-based). Currently available.
Concerta
10–12 hours.
Quillivant XR
Liquid methylphenidate ER. Often in good supply.
Strattera (atomoxetine)
Qelbree (viloxazine)
Intuniv (guanfacine ER)
Prefer Adzenys? We can find it.
MAO Inhibitors
moderateDo not take within 14 days.
Serotonergic drugs
moderateRisk of serotonin syndrome.
Blood pressure medications
moderateAdzenys may reduce their effectiveness.
Antacids and PPIs
moderateMay increase amphetamine absorption.
Vitamin C and acidic foods/drinks
moderateMay decrease absorption.
Tricyclic antidepressants
moderateCaffeine
moderateAlcohol
moderateAdzenys XR-ODT fills a unique niche as the only ADHD stimulant available as an orally disintegrating tablet. This makes it particularly valuable for patients who have difficulty swallowing pills — including children, elderly patients, or anyone who prefers a dissolvable format.
The lack of a generic version and limited insurance coverage make Adzenys expensive, but manufacturer coupons can significantly reduce costs. During the ADHD stimulant shortage, Adzenys is sometimes available when more commonly prescribed medications are not.
If you need an ODT format but can't find Adzenys, ask about Cotempla XR-ODT (methylphenidate-based). For liquid alternatives, Quillivant XR or Dynavel XR are worth considering.
Medfinder helps you find pharmacies with Adzenys in stock. Search for availability near you.
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