What Is Adzenys XR?

Adzenys XR (amphetamine extended-release orally disintegrating tablet) is a prescription stimulant medication used to treat attention deficit hyperactivity disorder (ADHD) in patients aged 6 and older.

What makes Adzenys XR different from other ADHD medications is its orally disintegrating tablet (ODT) form. You place it on your tongue and it dissolves — no water or swallowing a pill needed. This makes it especially helpful for children, older adults, or anyone who has trouble swallowing capsules or tablets.

Adzenys XR is manufactured by Tris Pharma and is classified as a Schedule II controlled substance by the DEA, meaning it has a recognized medical use but also a high potential for misuse.

What Is Adzenys XR Used For?

Adzenys XR is FDA-approved for one condition:

• ADHD (Attention Deficit Hyperactivity Disorder) — in patients aged 6 years and older, including children, adolescents, and adults.

ADHD is a neurodevelopmental disorder characterized by difficulty paying attention, hyperactivity, and impulsive behavior. Adzenys XR helps improve focus, reduce impulsivity, and manage hyperactivity throughout the day.

While other amphetamine formulations are sometimes used off-label for conditions like narcolepsy, Adzenys XR is specifically approved only for ADHD.

How Is Adzenys XR Taken?

Here's what you need to know about taking Adzenys XR:

• Dosage form: Extended-release orally disintegrating tablet
• Available strengths: 3.1 mg, 6.3 mg, 9.4 mg, 12.5 mg, 15.7 mg, and 18.8 mg
• How to take it: Place the tablet on your tongue and let it dissolve completely. Do not chew, crush, or split it. No water is needed.
• When to take it: Once daily in the morning. Taking it later in the day can cause trouble sleeping.
• With or without food: You can take Adzenys XR with or without food, but a high-fat meal may delay how quickly it starts working.

Typical Dosing

Your doctor will determine the right dose for you. Here are general starting points:

• Children (ages 6–12): Usually start at 6.3 mg once daily
• Adolescents and adults: Usually start at 12.5 mg once daily
• Maximum dose: 18.8 mg once daily

Your doctor may adjust your dose gradually based on how well the medication works and how you tolerate it. Never change your dose without talking to your doctor first.

To understand how this medication works in your body, read our explainer on how Adzenys XR works.

Who Should Not Take Adzenys XR?

Adzenys XR is not right for everyone. You should not take it if you have:

• A known allergy to amphetamine or any ingredients in Adzenys XR
• Taken an MAO inhibitor (MAOI) within the last 14 days
• Advanced hardening of the arteries (arteriosclerosis)
• Symptomatic cardiovascular disease
• Moderate to severe high blood pressure
• Hyperthyroidism (overactive thyroid)
• Glaucoma
• A history of drug abuse
• Agitated states or severe anxiety

Tell your doctor about all your medical conditions and medications before starting Adzenys XR. For a complete list of medications that can interact with it, see our guide on Adzenys XR drug interactions.

How Much Does Adzenys XR Cost?

Adzenys XR is a brand-name medication with no generic available as of 2026. Here's what you can expect to pay:

• Without insurance: $300 to $450 for a 30-day supply
• With insurance: Varies widely. Many plans require prior authorization or step therapy (trying a generic stimulant first). Some plans don't cover it at all.
• Manufacturer savings card: Tris Pharma offers a copay savings card that may reduce your cost to as low as $30 per fill for eligible commercially insured patients.

If cost is a concern, check out our detailed guide on saving money on Adzenys XR, which covers coupons, discount cards, and patient assistance programs.

Side Effects at a Glance

Common side effects of Adzenys XR include decreased appetite, insomnia, dry mouth, nausea, and irritability. Serious but rare side effects include cardiovascular events, psychiatric symptoms, and growth suppression in children.

For the full breakdown, read our article on Adzenys XR side effects.

Final Thoughts

Adzenys XR is a unique ADHD medication that offers the convenience of an orally disintegrating tablet with extended-release coverage throughout the day. It's a solid option for patients who struggle with swallowing pills or need a different formulation than traditional capsules.

If you've been prescribed Adzenys XR and are having trouble finding it at your pharmacy, Medfinder can help you locate it in stock near you. And if availability is an ongoing issue, your doctor can discuss alternative medications that may be easier to fill.