Comprehensive medication guide to {drug} including estimated pricing, availability information, side effects, and how to find it in stock at your local pharmacy.
Dexedrine (Dextroamphetamine sulfate) is a central nervous system (CNS) stimulant in the amphetamine class. It is FDA-approved for the treatment of Attention Deficit Hyperactivity Disorder (ADHD) and Narcolepsy.
Dextroamphetamine is the dextro-isomer of amphetamine and is considered more potent per milligram than mixed amphetamine salts (Adderall). It is available as immediate-release tablets, extended-release capsules (Dexedrine Spansule), an oral solution (ProCentra), and a transdermal patch (Xelstrym).
Dexedrine works by increasing the release and blocking the reuptake of two key neurotransmitters: norepinephrine and dopamine. By raising the levels of these chemicals in the brain, Dexedrine improves focus, attention, and impulse control in patients with ADHD, and promotes wakefulness in patients with Narcolepsy.
As a sympathomimetic amine, it also stimulates the peripheral nervous system, which can lead to increased heart rate and blood pressure — important considerations for prescribers and patients.
Typical dosing ranges from 5 mg to 60 mg per day, taken in divided doses (IR) or once daily (ER Spansule).
Dexedrine and generic Dextroamphetamine have been affected by the ongoing amphetamine shortage that began in October 2022. As a Schedule II controlled substance, supply is further constrained by DEA production quotas. Many patients report difficulty finding their specific dose or formulation in stock at local pharmacies.
The findability score of 45 out of 100 reflects frequent localized shortages across the U.S. While supply has improved for some formulations in early 2026, patients may still need to call multiple pharmacies or use tools like Medfinder to locate Dexedrine in stock near them.
Struggling to find {drug} in stock? We'll call the pharmacies, sit on hold, and find you one that can fill your prescription.
Because Dexedrine is a Schedule II controlled substance, it must be prescribed by a licensed provider with DEA authorization. Common prescribing specialties include:
Telehealth prescribing of Dexedrine is available through some platforms, though DEA regulations for Schedule II prescriptions require compliance with state and federal rules. A new prescription is needed each month — no refills are allowed for Schedule II medications.
Yes. Dexedrine is classified as a Schedule II (CII) controlled substance by the DEA. This is the highest schedule for drugs with accepted medical use, indicating a high potential for abuse that may lead to severe psychological or physical dependence.
Schedule II medications carry restrictions including: no refills (a new prescription each fill), limits on quantity dispensed, and requirements for written or electronic prescriptions in most states. The DEA also controls annual production quotas for amphetamine products, which has contributed to the ongoing shortage.
Serious side effects that require immediate medical attention include chest pain, shortness of breath, signs of circulation problems (numbness, color changes in fingers/toes), psychosis or hallucinations, seizures, and signs of serotonin syndrome (agitation, rapid heartbeat, fever, muscle twitching).
Boxed Warning: Amphetamines have a high potential for abuse and dependence. Misuse can cause sudden death and serious cardiovascular events. Use only as prescribed.
If you're unable to find Dexedrine or it's not the right fit, your prescriber may consider these alternatives:
Always consult your prescriber before switching medications. You can use Medfinder to check availability of any alternative near you.
Major interactions (avoid):
Moderate interactions:
Always tell your doctor and pharmacist about all medications, supplements, and herbal products you take.
Dexedrine remains an effective and well-established treatment for ADHD and Narcolepsy, but the ongoing stimulant shortage has made it harder to find in stock. With a findability score of 45/100, patients should expect to encounter availability challenges — especially for specific doses and formulations.
Using tools like Medfinder can save hours of calling pharmacies. Consider discount cards from GoodRx or SingleCare to bring cash prices as low as $20 for generic Dextroamphetamine tablets. Talk to your prescriber about alternatives like Vyvanse, Adderall, or Zenzedi if your current formulation is consistently unavailable.
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