Comprehensive medication guide to Quillivant XR including estimated pricing, availability information, side effects, and how to find it in stock at your local pharmacy.
Estimated Insurance Pricing
$20–$75 copay with commercial insurance; prior authorization and step therapy often required.
Estimated Cash Pricing
$328–$480 per bottle (120 mL) without insurance; eligible patients may pay as little as $20 with the Tris Pharma Savings Card.
Medfinder Findability Score
45/100
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Quillivant XR is a brand-name, extended-release liquid form of methylphenidate — one of the most widely prescribed medications for Attention Deficit Hyperactivity Disorder (ADHD). It is FDA-approved for patients aged 6 years and older. Unlike tablets or capsules, Quillivant XR is an oral suspension (liquid), making it an ideal option for children or adults who have difficulty swallowing pills.
Quillivant XR is manufactured by Tris Pharma, Inc. and provides up to 12 hours of symptom control with a single morning dose.
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Quillivant XR belongs to the class of central nervous system (CNS) stimulants. It works by blocking the reuptake of two key neurotransmitters — norepinephrine and dopamine — into presynaptic neurons. This increases their availability in the brain, which helps improve attention, focus, and impulse control in patients with ADHD.
The extended-release formulation uses a proprietary liquid delivery system that releases methylphenidate gradually throughout the day, providing consistent symptom management without the need for a midday dose.
Extended-release oral suspension — suspension
25 mg per 5 mL (5 mg/mL) after reconstitution, supplied in a 120 mL bottle
Typical daily dose range
20 mg to 60 mg taken once daily in the morning
Quillivant XR has a findability score of 45 out of 100, meaning it is moderately difficult to find in stock at your local pharmacy. The medication has been listed on the FDA drug shortage list since 2023 due to manufacturing issues at Tris Pharma and heightened demand for methylphenidate products during the broader ADHD stimulant shortage. Many pharmacies report intermittent or localized stockouts, and some have flagged it as temporarily discontinued.
If your pharmacy doesn't have it, try using Medfinder to search for pharmacies near you that currently have Quillivant XR in stock — it can save you hours of calling around.
Because Quillivant XR is a Schedule II controlled substance, it must be prescribed by a licensed healthcare provider with DEA prescribing authority. Common prescribers include:
Telehealth prescribing is available for Quillivant XR in many states, though regulations for Schedule II stimulants vary.
Yes. Quillivant XR is classified as a Schedule II (CII) controlled substance by the DEA. This is the same scheduling category as Adderall, Concerta, and Ritalin. Schedule II drugs have a high potential for abuse and misuse, which can lead to physical or psychological dependence.
The FDA-required boxed warning states: "Quillivant XR has a high potential for abuse and misuse, which can lead to the development of a substance use disorder, including addiction." Your doctor should assess risk before prescribing and monitor you during treatment.
Serious side effects are rare but may include sudden cardiac events in patients with heart defects, new or worsening psychiatric symptoms (hallucinations, mania), peripheral vasculopathy (Raynaud's phenomenon), priapism, seizures, and growth suppression in children. Contact your doctor immediately if you experience any serious symptoms.
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Concerta (Methylphenidate ER Tablets)
long-acting tablet form of methylphenidate with 12-hour duration
Ritalin LA (Methylphenidate ER Capsules)
extended-release capsule that can be opened and sprinkled on food
Focalin XR (Dexmethylphenidate ER Capsules)
contains only the active d-isomer of methylphenidate
Dyanavel XR (Amphetamine ER Oral Suspension)
another liquid stimulant option, also made by Tris Pharma, but amphetamine-based
QuilliChew ER
an extended-release chewable tablet form of methylphenidate, also from Tris Pharma
Prefer Quillivant XR? We can find it.
MAO inhibitors
moderateDo NOT take Quillivant XR with or within 14 days of an MAOI (risk of hypertensive crisis)
Blood pressure medications
moderateQuillivant XR may reduce the effectiveness of antihypertensives
Blood thinners (Coumarin anticoagulants)
moderatemethylphenidate may inhibit their metabolism
Anticonvulsants and tricyclic antidepressants
moderatemethylphenidate may increase blood levels of these drugs
SSRIs and SNRIs
moderatepotential for increased serotonergic effects
Alcohol
moderatemay cause faster release of methylphenidate; avoid completely
Quillivant XR fills an important niche as one of the few long-acting liquid methylphenidate options for ADHD. It's especially valuable for children and patients who can't swallow pills. However, with no generic available and ongoing supply disruptions since 2023, finding it in stock and affording it can be a real challenge.
If you're struggling to find Quillivant XR, try Medfinder to locate pharmacies that have it in stock near you. For cost savings, check the Tris Pharma Savings Card at trissavingscard.com — eligible patients may pay as little as $20 per fill. You can also explore patient assistance through NeedyMeds and RxAssist.
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Our medication guides are researched and written to help patients make informed decisions. All content is reviewed for accuracy and updated regularly. Learn more about our standards
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