Adzenys XR Drug Interactions You Should Know About

If you take Adzenys XR for ADHD, it's important to know which medications, supplements, and even foods can interact with it. Some interactions can make Adzenys XR less effective, while others can cause dangerous side effects.

This guide covers the most important drug interactions, what to avoid, and what to tell your doctor before starting or changing your treatment.

How Drug Interactions Work with Adzenys XR

Adzenys XR contains amphetamine, which affects neurotransmitters like dopamine and norepinephrine in the brain. Drug interactions can happen in several ways:

• Another drug increases the effects of amphetamine — This can lead to dangerously high stimulant activity, raising blood pressure, heart rate, or risk of serotonin syndrome.
• Another drug decreases the effects of amphetamine — This can make your ADHD medication less effective.
• Amphetamine changes how another drug works — Adzenys XR can increase or decrease the effectiveness of other medications you take.
• Changes in urine pH — This is unique to amphetamine. Acidic urine speeds up elimination (less effective), while alkaline urine slows elimination (stronger effect).

Medications That Interact with Adzenys XR

MAO Inhibitors (Contraindicated)

This is the most dangerous interaction. Do not take Adzenys XR if you have used an MAO inhibitor within the past 14 days. MAOIs include medications like phenelzine (Nardil), tranylcypromine (Parnate), and selegiline (Emsam). Combining these with amphetamine can cause a hypertensive crisis — a sudden, dangerous spike in blood pressure.

Serotonergic Medications

Taking Adzenys XR with drugs that increase serotonin levels can lead to serotonin syndrome, a potentially life-threatening condition. Watch out for combinations with:

• SSRIs — Fluoxetine (Prozac), sertraline (Zoloft), escitalopram (Lexapro)
• SNRIs — Venlafaxine (Effexor), duloxetine (Cymbalta)
• Triptans — Sumatriptan (Imitrex) and other migraine medications
• Tramadol — A pain medication with serotonergic effects

Symptoms of serotonin syndrome include agitation, rapid heartbeat, high body temperature, muscle rigidity, and loss of coordination. Seek emergency care immediately if you experience these symptoms.

CYP2D6 Inhibitors

Drugs that inhibit the CYP2D6 enzyme can increase amphetamine levels in your blood, potentially increasing side effects. These include:

• Fluoxetine (Prozac)
• Paroxetine (Paxil)
• Bupropion (Wellbutrin)
• Quinidine

Blood Pressure Medications

Adzenys XR can raise blood pressure. If you take antihypertensive medications, the stimulant may reduce their effectiveness. Your doctor may need to adjust your blood pressure medication doses.

Tricyclic Antidepressants (TCAs)

Amphetamine can enhance the effects of TCAs like amitriptyline, nortriptyline, and desipramine. This can increase the risk of cardiovascular side effects.

Anticonvulsants

If you take seizure medications, be aware that amphetamines may lower the seizure threshold. Your doctor may need to adjust your anticonvulsant dosage.

Supplements and Over-the-Counter Medications

Some common supplements and OTC products can also interact with Adzenys XR:

• Vitamin C (ascorbic acid) — High doses of Vitamin C acidify your urine, which causes your body to eliminate amphetamine faster. This can make Adzenys XR less effective.
• Antacids and baking soda — These alkalinize your urine, which slows amphetamine elimination and can increase its effects and side effects.
• Proton pump inhibitors (PPIs) — Omeprazole (Prilosec), esomeprazole (Nexium) — may alter absorption.
• Decongestants — Pseudoephedrine and phenylephrine are stimulants themselves. Combining them with Adzenys XR can increase blood pressure and heart rate.
• Caffeine supplements — High-dose caffeine pills can intensify stimulant side effects like anxiety, rapid heartbeat, and insomnia.

Food and Drink Interactions

What you eat and drink can also affect how Adzenys XR works:

• Acidic fruit juices — Orange juice, grapefruit juice, and other citrus juices can acidify your urine and reduce amphetamine absorption. Avoid drinking large amounts close to when you take your medication.
• High-fat meals — A high-fat meal can delay how quickly Adzenys XR starts working, though it doesn't reduce the total amount absorbed.
• Caffeine — Coffee, energy drinks, and tea can add to the stimulant effects of Adzenys XR, potentially increasing jitteriness, anxiety, and heart rate.
• Alcohol — Alcohol can worsen side effects and impair judgment. It's best to limit or avoid alcohol while taking any stimulant medication.

What to Tell Your Doctor

Before starting Adzenys XR, make sure your doctor knows about:

• All prescription medications you currently take, including antidepressants, blood pressure medications, and seizure medications
• All over-the-counter medications, including cold medicines, antacids, and pain relievers
• All supplements, including Vitamin C, herbal products, and protein supplements
• Your caffeine intake, including coffee, tea, and energy drinks
• Any history of drug interactions or adverse reactions to medications

Keep an updated medication list and share it at every appointment. If a new provider prescribes you anything, remind them that you take Adzenys XR.

For more on Adzenys XR side effects, read our dedicated guide.

Final Thoughts

Drug interactions with Adzenys XR range from mildly inconvenient to potentially dangerous. The most critical one to remember: never combine Adzenys XR with MAO inhibitors. Beyond that, being honest with your doctor about everything you take — prescriptions, supplements, and even your morning orange juice — is the best way to stay safe.

If you're currently taking Adzenys XR and need help finding it at a pharmacy, Medfinder can help you check stock near you.