When Your Pharmacy Can't Fill Adzenys XR

If you've been prescribed Adzenys XR-ODT for ADHD and your pharmacy keeps telling you it's out of stock, you're not alone. The ongoing stimulant shortage has made brand-name medications like Adzenys XR especially difficult to find in 2026.

The good news is that there are several effective alternatives in the same drug class. In this article, we'll explain what Adzenys XR is, how it works, and walk you through four real alternatives you can discuss with your doctor.

Important: Never switch medications on your own. Always talk to your prescriber before making any changes to your ADHD treatment.

What Is Adzenys XR?

Adzenys XR-ODT is a brand-name, extended-release amphetamine that comes in an orally disintegrating tablet (ODT). You place it on your tongue and it dissolves — no water needed. It's approved by the FDA for the treatment of ADHD in patients aged 6 years and older.

The medication is manufactured by Tris Pharma and comes in six strengths: 3.1 mg, 6.3 mg, 9.4 mg, 12.5 mg, 15.7 mg, and 18.8 mg. It's a Schedule II controlled substance, just like all amphetamine-based ADHD medications.

For a deeper dive into the medication, see our full guide: What Is Adzenys XR? Uses, Dosage, and What You Need to Know.

How Does Adzenys XR Work?

Adzenys XR-ODT contains amphetamine, which works by increasing the levels of two key brain chemicals: dopamine and norepinephrine. These neurotransmitters play a critical role in attention, focus, and impulse control.

The "XR" in the name stands for extended-release. The tablet uses a special bead technology that releases about 50% of the medication immediately and the other 50% gradually over several hours. This provides symptom control that can last up to 12 hours with a single morning dose.

For more details, read How Does Adzenys XR Work? Mechanism of Action Explained.

4 Alternatives to Adzenys XR

The following medications are in the same drug class as Adzenys XR and treat ADHD in a similar way. Each has its own unique characteristics that may make it a better or worse fit for you.

1. Adderall XR (Mixed Amphetamine Salts, Extended-Release)

Adderall XR is one of the most widely prescribed ADHD medications in the United States. It contains a mixture of four amphetamine salts and is available as an extended-release capsule that's taken once daily.

• How it compares: Adderall XR contains the same active ingredient class (amphetamine) as Adzenys XR but in a swallowable capsule form rather than an orally disintegrating tablet. The capsule can be opened and sprinkled on applesauce for patients who can't swallow pills.
• Generic available: Yes. Generic Adderall XR is widely available and typically costs $30 to $80 per month without insurance — significantly less than brand-name Adzenys XR.
• Strengths: 5 mg, 10 mg, 15 mg, 20 mg, 25 mg, 30 mg
• Duration: Up to 12 hours

2. Vyvanse (Lisdexamfetamine Dimesylate)

Vyvanse is a unique stimulant because it's a prodrug — meaning it must be converted by the body into its active form (d-amphetamine) before it works. This conversion process provides a smoother onset and may reduce the potential for abuse.

• How it compares: Vyvanse tends to have a gentler "on" and "off" compared to Adzenys XR. Some patients report fewer peaks and valleys throughout the day. It's available as capsules and chewable tablets.
• Generic available: Yes, as of 2023. Generic lisdexamfetamine has brought costs down significantly, typically ranging from $30 to $100 per month.
• Strengths: 10 mg, 20 mg, 30 mg, 40 mg, 50 mg, 60 mg, 70 mg
• Duration: Up to 14 hours

3. Dyanavel XR (Amphetamine Extended-Release Oral Suspension)

Dyanavel XR is another product by Tris Pharma — the same company that makes Adzenys XR. It's an amphetamine extended-release oral suspension (liquid) that's taken once daily.

• How it compares: Like Adzenys XR, Dyanavel XR is ideal for patients who can't swallow pills. It's a liquid that can be measured precisely, making dose adjustments easier. It uses the same extended-release bead technology.
• Generic available: No. Dyanavel XR is brand-name only, which means it may also be expensive and potentially hard to find.
• Strength: 2.5 mg/mL oral suspension
• Duration: Up to 13 hours

4. Mydayis (Mixed Amphetamine Salts, Triple-Bead Extended-Release)

Mydayis is a triple-bead extended-release capsule that provides up to 16 hours of ADHD symptom coverage. It was designed for patients who need longer-lasting medication, such as adults with demanding work or school schedules.

• How it compares: Mydayis lasts significantly longer than Adzenys XR (16 hours vs. 12 hours). However, the extended duration may also mean more sustained side effects like appetite suppression and insomnia.
• Generic available: No. Mydayis is brand-name only and typically costs $300 to $400 per month without insurance.
• Strengths: 12.5 mg, 25 mg, 37.5 mg, 50 mg
• Duration: Up to 16 hours

How to Talk to Your Doctor About Switching

If you can't find Adzenys XR and want to explore alternatives, here's how to approach the conversation with your prescriber:

1. Explain the situation: Let them know you've been unable to fill your prescription and for how long.
2. Share your preferences: Do you need a non-pill form? Is cost a concern? Do you need longer or shorter duration?
3. Ask about dose equivalence: Your doctor can calculate the equivalent dose when switching between amphetamine products.
4. Discuss a trial period: Any new medication takes time to evaluate. Plan for a follow-up visit 2-4 weeks after switching.

You may also want to use Medfinder to check availability of the alternative medication before your doctor writes the prescription. There's no point switching to something that's also out of stock.

Final Thoughts

Not being able to fill your Adzenys XR prescription is stressful, especially when your ADHD symptoms depend on consistent medication. But you have options. Adderall XR, Vyvanse, Dyanavel XR, and Mydayis all treat ADHD through similar mechanisms and may be suitable alternatives.

Talk to your doctor, use Medfinder to check availability, and remember — switching medications doesn't have to be permanent. Once Adzenys XR is back in stock, you and your prescriber can decide whether to switch back.

For help finding Adzenys XR right now, check our guide: How to Find Adzenys XR in Stock Near You.