How Adzenys XR Works — In Plain English

Adzenys XR works by increasing the levels of two brain chemicals — dopamine and norepinephrine — that play a key role in attention, focus, and impulse control.

If you've been prescribed Adzenys XR or are considering it for ADHD, understanding how it works can help you know what to expect. This guide breaks down the mechanism of action in simple terms.

What Adzenys XR Does in Your Brain

Adzenys XR contains amphetamine, which belongs to a class of drugs called central nervous system (CNS) stimulants. Here's what happens when you take it:

1. It triggers the release of dopamine and norepinephrine — These are neurotransmitters, which are chemical messengers in your brain. Dopamine is linked to motivation, reward, and focus. Norepinephrine is linked to alertness and attention.
2. It blocks the reuptake of these chemicals — Normally, after dopamine and norepinephrine do their job, your brain reabsorbs them. Amphetamine slows this process down, so more of these chemicals stay active in the spaces between brain cells.
3. The result: Your brain has more dopamine and norepinephrine available to use, which improves your ability to focus, control impulses, and stay on task.

In people with ADHD, the brain's dopamine and norepinephrine systems often don't function as efficiently. Adzenys XR helps correct this imbalance — it's not giving your brain something it doesn't need, but rather helping it work the way it's supposed to.

How Long Does It Take to Work?

Adzenys XR is an extended-release medication, but it's designed to start working relatively quickly:

• Initial effects: Most people notice effects within 1 to 2 hours of taking the tablet.
• Full therapeutic effect: It may take several days to a few weeks of consistent use for you and your doctor to determine the optimal dose and see the full benefits.

Because Adzenys XR is an orally disintegrating tablet, it dissolves on your tongue and is absorbed through your digestive system. A high-fat meal can delay absorption, so taking it before breakfast or with a light meal is usually best.

How Long Does Adzenys XR Last?

Adzenys XR is formulated to provide coverage throughout the day:

• Duration: Approximately 10 to 12 hours for most patients
• Once-daily dosing: You take it in the morning and it's designed to last through the school or work day

The "XR" stands for extended-release. The tablet uses a special technology to release amphetamine in two phases — an initial dose for quick onset, followed by a gradual release for sustained coverage throughout the day.

As the medication wears off in the evening, some people experience a "rebound" effect — a temporary return of ADHD symptoms or irritability. If this happens, talk to your doctor about adjusting your dose or timing.

What Makes Adzenys XR Different from Other ADHD Medications?

There are many ADHD medications available. Here's what sets Adzenys XR apart:

• Orally disintegrating tablet (ODT) — Unlike capsules (Adderall XR, Vyvanse) or regular tablets, Adzenys XR dissolves on your tongue without water. This is ideal for people who can't swallow pills.
• Extended-release amphetamine — It provides all-day coverage similar to Adderall XR, but in a different delivery format.
• Single-entity amphetamine — Adzenys XR contains only amphetamine (not mixed amphetamine salts like Adderall). This may matter for some patients who respond differently to specific amphetamine formulations.

Compared to other options:

• Adderall XR — Contains mixed amphetamine salts in a capsule. More widely available and has generic options.
• Vyvanse — A prodrug (lisdexamfetamine) that converts to amphetamine in the body. Designed to have lower abuse potential.
• Dyanavel XR — An amphetamine liquid suspension, also made by Tris Pharma. Good for patients who prefer liquid medication.
• Mydayis — A triple-bead mixed amphetamine salt that lasts up to 16 hours.

For a full comparison of alternatives, read our guide on alternatives to Adzenys XR.

Final Thoughts

Adzenys XR works by boosting the brain chemicals that help you focus and control impulses. Its extended-release design means one morning dose covers you for most of the day, and its dissolving tablet format makes it easy to take.

If you want to learn more about this medication, check out our complete guide: What Is Adzenys XR? Uses, Dosage, and What You Need to Know. And if you're ready to fill your prescription, Medfinder can help you find it in stock near you.