Comprehensive medication guide to Treximet including estimated pricing, availability information, side effects, and how to find it in stock at your local pharmacy.
Estimated Insurance Pricing
With insurance, expect $30–$75 per fill for generic Sumatriptan/Naproxen Sodium, though brand Treximet often requires prior authorization.
Estimated Cash Pricing
Without insurance, Treximet costs $500–$900 for 9 brand-name tablets, or $130–$250 for 9 generic tablets with a discount coupon.
Medfinder Findability Score
45/100
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Treximet is a prescription combination medication used for the acute treatment of migraine attacks with or without aura in adults. It combines two active ingredients — Sumatriptan (a triptan) and Naproxen Sodium (an NSAID) — into a single tablet. By pairing both drugs together, Treximet attacks migraine pain through two different mechanisms simultaneously, which clinical studies have shown to be more effective than either drug taken alone. It is manufactured by Currax Pharmaceuticals.
Treximet works through two complementary mechanisms:
![How to Find a Doctor Who Can Prescribe Treximet Near You [2026 Guide]](/_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2Fvur4atr4%2Fproduction%2F24b24f75a78fc8b3127f28ffe8f2513f00e27c83-1024x1024.png%3Frect%3D0%2C256%2C1024%2C512%26w%3D400%26h%3D200%26auto%3Dformat&w=828&q=75)
![Why Is Treximet So Hard to Find? [Explained for 2026]](/_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2Fvur4atr4%2Fproduction%2Fd8879fac3f00b1e7d251c89eff45ff25d127e40f-1024x1024.png%3Frect%3D0%2C256%2C1024%2C512%26w%3D400%26h%3D200%26auto%3Dformat&w=828&q=75)
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Together, these two mechanisms provide faster and more sustained migraine relief than either ingredient alone.
85 mg Sumatriptan / 500 mg Naproxen Sodium
the standard adult tablet and the only currently available strength
Treximet scores a 45 out of 100 on our findability scale, meaning it can be moderately difficult to locate at your local pharmacy. Because Treximet is a niche combination product (Sumatriptan + Naproxen Sodium in a single tablet), many retail pharmacies simply don't stock it. The brand-name version is especially hard to find on shelves. The generic is more widely available but still not carried everywhere. Your best bet is to call ahead or use Medfinder to check stock before making a trip.
Treximet can be prescribed by a range of healthcare providers, including:
Telehealth providers can also prescribe Treximet, making it accessible without an in-person visit for established migraine patients.
No, Treximet is not a controlled substance. It does not have a DEA schedule and is not subject to the prescribing restrictions that apply to controlled medications. However, it does require a prescription and carries two FDA boxed warnings regarding cardiovascular and gastrointestinal risks from the Naproxen Sodium component.
Serious but rare side effects include heart attack, stroke, serotonin syndrome, and gastrointestinal bleeding. Treximet carries two FDA boxed warnings for cardiovascular and GI risks. Seek immediate medical attention if you experience severe chest pain, sudden weakness, or signs of GI bleeding.
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Sumatriptan (Imitrex) + over-the-counter Naproxen Sodium (Aleve)
the same two ingredients taken separately, often much cheaper
Rizatriptan (Maxalt)
a fast-acting triptan for acute migraine
Eletriptan (Relpax)
another effective triptan option
Ubrogepant (Ubrelvy)
a newer CGRP receptor antagonist that works differently from triptans and may be suitable for patients who can't tolerate triptans
Prefer Treximet? We can find it.
MAO inhibitors
moderatecontraindicated within 14 days of use
Other triptans or ergotamine medications
moderatedo not use within 24 hours
SSRIs and SNRIs
moderate(e.g., Sertraline, Venlafaxine) — increased risk of serotonin syndrome
Blood thinners
moderate(e.g., Warfarin) — increased bleeding risk
Lithium
moderateNaproxen can increase lithium levels
Methotrexate
moderateincreased toxicity risk
ACE inhibitors and ARBs
moderatereduced blood pressure-lowering effect
Alcohol
moderateincreases risk of GI bleeding
Treximet is an effective combination medication for acute migraine relief, but its niche status and higher cost can make it challenging to find and afford. With a findability score of 45, many pharmacies simply don't carry it. If cost is a concern, check the manufacturer's website at treximet.com for their authorized generic program at $75 or less for 9 tablets. Alternatively, taking generic Sumatriptan with over-the-counter Naproxen Sodium (Aleve) separately can provide similar relief at a fraction of the cost. Use Medfinder to quickly locate pharmacies that have Treximet in stock near you.
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Our medication guides are researched and written to help patients make informed decisions. All content is reviewed for accuracy and updated regularly. Learn more about our standards
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