If You Can't Find Treximet, You're Not Alone

You get a migraine, your doctor prescribes Treximet, and you head to the pharmacy — only to hear those frustrating words: "We don't have it in stock." If this sounds familiar, you're not imagining things. Treximet has become increasingly difficult to find at many pharmacies across the United States.

In this article, we'll explain what Treximet is, why it's so hard to find in 2026, and what steps you can take to get your prescription filled.

What Is Treximet?

Treximet is a prescription medication used for the acute treatment of migraine attacks with or without aura in adults. It combines two active ingredients in a single tablet:

• Sumatriptan (85 mg) — a triptan that works by narrowing blood vessels in the brain and blocking pain signals
• Naproxen Sodium (500 mg) — an NSAID (nonsteroidal anti-inflammatory drug) that reduces inflammation and pain

By combining a triptan and an NSAID, Treximet attacks migraine pain through two different mechanisms at once, which studies have shown can be more effective than taking either drug alone. It's manufactured by Currax Pharmaceuticals and was first approved by the FDA in 2008.

For a deeper dive into how this medication works, check out our article on how Treximet works.

Why Is Treximet So Hard to Find?

There are several reasons why you might be having trouble filling your Treximet prescription in 2026:

1. It's a Niche Combination Product

Treximet is the only FDA-approved combination of a triptan and an NSAID in a single tablet. Because many doctors simply prescribe Sumatriptan and Naproxen separately (which is cheaper), pharmacies may not keep Treximet on their shelves. Low demand at individual pharmacies means they often don't stock it.

2. High Cost Limits Prescribing

Brand-name Treximet can cost $500 to $900 for just 9 tablets without insurance. Even with the generic (Sumatriptan/Naproxen Sodium), prices can run $130 to $250 for 9 tablets with a discount card. This high price tag means fewer prescriptions are written, and pharmacies are less likely to stock a medication that rarely gets requested.

3. Insurance Barriers

Many insurance plans require prior authorization or step therapy before they'll cover Treximet. Step therapy means your insurer may require you to try a standalone triptan like Sumatriptan (Imitrex) first. If the standalone triptan works, the insurance company won't cover the combination. This further reduces how often pharmacies see Treximet prescriptions come through.

4. The Pediatric Formulation Was Discontinued

Treximet previously came in a lower-dose pediatric formulation (10 mg Sumatriptan / 60 mg Naproxen Sodium), but this was discontinued. Only the adult-strength 85/500 mg tablet is currently available. This doesn't directly affect adult patients, but it reflects the shrinking market for the product overall.

What You Can Do

If you're struggling to find Treximet, here are some practical steps:

Use Medfinder to Check Pharmacy Stock

Rather than calling pharmacy after pharmacy, use Medfinder to quickly check which pharmacies near you have Treximet in stock. It saves you time and frustration.

Try Independent Pharmacies

Independent pharmacies are often more willing to order medications they don't regularly stock. They may also have better relationships with wholesalers and can get Treximet within a day or two.

Order Directly from Treximet.com

Currax Pharmaceuticals offers Treximet (both brand and authorized generic) directly through treximet.com for $75 to $99 for 9 tablets with free shipping. This can be a convenient option if local pharmacies don't carry it.

Ask Your Doctor About Alternatives

If you simply can't find Treximet, your doctor may suggest taking Sumatriptan and Naproxen Sodium separately, which achieves a similar effect. Other options include Rizatriptan (Maxalt), Eletriptan (Relpax), or newer medications like Ubrogepant (Ubrelvy). Read more in our guide to alternatives to Treximet.

Save Money with Coupons

High cost is a major reason pharmacies don't stock Treximet. Using discount cards from GoodRx or SingleCare can bring the generic price down to around $130 for 9 tablets. Learn more in our article on how to save money on Treximet.

Final Thoughts

Treximet is a proven, effective migraine treatment — but it's not always easy to find. The combination of high cost, insurance hurdles, and low pharmacy demand means you may need to be proactive about getting your prescription filled. The good news is that tools like Medfinder, direct ordering from the manufacturer, and discount programs can help you get the medication you need.

If you're having ongoing trouble, talk to your doctor about whether alternative medications might work for you, or check our guide on how to find Treximet in stock near you.