Can't find or afford Treximet? Here are the best alternatives for migraine treatment in 2026, from taking the ingredients separately to newer options.
If your pharmacy can't fill your Treximet prescription — or the cost is just too high — don't give up on effective migraine treatment. There are several alternatives that work through similar mechanisms, and your doctor can help you find one that fits.
In this guide, we'll explain what Treximet does, how it works, and walk through the best alternative medications available in 2026.
Treximet is a prescription tablet that combines two active ingredients to treat acute migraine attacks:
This two-in-one approach targets migraine through both vascular and inflammatory pathways, and studies have shown the combination can be more effective than either ingredient alone.
For a full breakdown, see our article on what Treximet is and how to use it.
During a migraine, blood vessels in the brain expand and trigger inflammation along the trigeminal nerve pathway. Treximet works by:
Together, these two mechanisms provide faster, more complete migraine relief than a triptan or NSAID alone. Learn more in our detailed article on how Treximet works.
This is the most straightforward alternative. Instead of one combination tablet, you take:
The total cost is a fraction of what Treximet costs, and you're getting the same active ingredients. The main difference is that Treximet uses a proprietary formulation that may absorb slightly differently than taking the two drugs as separate tablets.
Best for: Patients who want the same drug combination at a much lower cost.
Rizatriptan is another triptan in the same class as Sumatriptan. It comes as a regular tablet or an orally disintegrating tablet (ODT) that melts on the tongue — helpful if nausea makes it hard to swallow pills during a migraine.
Best for: Patients who get nauseous during migraines or want a fast-acting triptan.
Eletriptan is considered one of the more potent triptans. Some studies suggest it provides stronger and more sustained relief compared to Sumatriptan, especially for moderate to severe migraines.
Best for: Patients who need stronger migraine relief or haven't responded well to Sumatriptan.
Ubrogepant is a newer type of migraine medication called a CGRP receptor antagonist (or "gepant"). It works differently from triptans — it blocks calcitonin gene-related peptide (CGRP), a protein involved in migraine pain — and doesn't cause blood vessel constriction.
Best for: Patients who can't take triptans due to cardiovascular risk factors, or who haven't responded to triptans.
The best alternative depends on your situation:
Always talk to your doctor before switching medications. They can consider your migraine history, other medications you take (check our guide on Treximet drug interactions), and any health conditions you have.
If you prefer to stay on Treximet, there are ways to find it:
Not being able to fill your Treximet prescription is frustrating, but it doesn't mean you're out of options. Whether you take the same ingredients separately, try a different triptan, or explore newer CGRP medications, there are effective migraine treatments available. Work with your doctor to find the right fit, and use tools like Medfinder to track down whatever medication works best for you.
You focus on staying healthy. We'll handle the rest.
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