Help patients afford Treximet with this provider guide to savings programs, discount cards, generic alternatives, and cost conversation strategies.
You prescribe Treximet (Sumatriptan/Naproxen Sodium) because it works — the combination tablet offers superior sustained pain freedom compared to either component alone, and many patients prefer the convenience of a single-tablet regimen. But when your patient gets to the pharmacy and sees a bill of $500–$900 for 9 brand-name tablets, adherence can fall apart fast.
Cost-related non-adherence is a well-documented problem in migraine treatment. Patients may ration doses, delay treatment, or simply never fill the prescription. As a provider, you can make a significant difference by building cost awareness into your prescribing workflow. This guide covers the savings options available for Treximet and practical strategies for integrating cost conversations into patient care.
Understanding the price landscape helps you set expectations and guide patients to the best option.
The manufacturer direct-purchase option is often the most affordable route, even compared to insurance copays in many cases. This is worth mentioning to patients at the point of prescribing.
Currax Pharmaceuticals, the manufacturer of Treximet, operates a direct-purchase program through treximet.com that bypasses traditional pharmacy channels:
This program is particularly valuable because it solves two problems at once — cost and availability. Treximet can be difficult to find at retail pharmacies, and directing patients to treximet.com ensures they can actually get the medication filled.
Consider adding a note to your prescription or after-visit summary: "Treximet may be available for $75 or less through treximet.com with free shipping." This one sentence can prevent the sticker shock that leads to abandoned prescriptions.
For patients who prefer to fill at a local pharmacy — or if the manufacturer program doesn't work for their situation — discount cards can significantly reduce costs on the generic.
Important note for providers: Discount cards cannot be combined with insurance. They are most useful for uninsured patients or when the insurance copay is higher than the discount card price (which happens more often than you'd expect with Treximet).
Advise patients to compare their insurance copay against the GoodRx price before filling. In some cases, the discount card price for generic Treximet is lower than the insurance copay, especially for plans with high-deductible or specialty-tier pricing.
The generic is bioequivalent to brand-name Treximet and is always the first-line cost-saving option. When writing prescriptions, ensure you allow generic substitution (or prescribe by generic name) unless there's a clinical reason for brand-only.
For patients with extreme cost constraints, prescribing Sumatriptan and Naproxen Sodium as separate medications can be significantly cheaper:
This approach costs roughly $20–$40 total compared to $130+ for the combination tablet. The trade-off is that Treximet's formulation is designed for faster absorption, and patient compliance may be lower with two separate medications. However, for a patient who otherwise wouldn't fill the prescription at all, separate components are clearly preferable.
If cost is prohibitive and the patient hasn't tried other triptans, consider whether an alternative triptan might be appropriate:
For patients who specifically benefit from the combination mechanism, alternatives to Treximet may not provide the same sustained relief. Document your clinical rationale if prior authorization is needed.
For patients with financial hardship — particularly uninsured or underinsured patients — several resources exist:
These programs typically require income verification and may take several weeks to process, so they're best suited for patients with ongoing medication needs rather than acute situations.
The most effective intervention is simply talking about cost before the patient leaves your office. Here are practical strategies:
A simple question — "Do you have any concerns about prescription costs?" — can open a productive conversation. Many patients don't mention cost barriers because they assume the doctor can't help, or they feel embarrassed.
If your EHR includes real-time benefit check (RTBC) tools, use them. If not, a general price range helps patients prepare:
Consider creating a simple handout or template in your EHR with Treximet cost options that can be included in after-visit summaries. Include:
Check at follow-up visits whether the patient actually filled the prescription. If they didn't, cost is often the reason. This is your opportunity to discuss alternatives or connect them with savings programs.
Many insurers require step therapy (trying a standalone triptan first) before covering Treximet. If your patient has already tried and failed Sumatriptan alone, document this clearly in the chart and include it in the initial prior authorization request. This can save weeks of back-and-forth with the insurer.
Medfinder for Providers helps you and your staff quickly check which pharmacies near your patients have Treximet in stock. This is especially useful when you're writing a new prescription — rather than sending the patient to a pharmacy that may not carry it, you can direct them to one that does. This reduces abandoned prescriptions and improves the patient experience.
Treximet is a clinically effective migraine treatment that too often goes unfilled due to cost. By proactively discussing pricing, directing patients to the manufacturer's direct-purchase program ($75 for the authorized generic), recommending discount cards, and considering separate-component prescribing when necessary, you can significantly improve adherence and patient outcomes.
The key takeaway: a 30-second cost conversation at the point of prescribing can be the difference between a patient who fills their prescription and one who doesn't. Your patients will appreciate the transparency, and their migraines will thank you.
For more resources, visit Medfinder for Providers to help your patients find Treximet in stock. Also see our related provider guides on helping patients find Treximet and the Treximet shortage update for prescribers.
You focus on staying healthy. We'll handle the rest.
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