Treximet Is a Prescription Combination Tablet Used to Treat Acute Migraine Attacks in Adults

Treximet (Sumatriptan/Naproxen Sodium) is a prescription medication that combines two active ingredients in a single tablet to stop migraines once they start. It's one of the few FDA-approved combination products designed specifically for acute migraine treatment. Here's everything you need to know about what it is, how to take it, and what it costs in 2026.

What Is Treximet?

Treximet is the brand name for a combination tablet containing:

• Sumatriptan (85 mg) — A triptan, which is a class of drugs that target serotonin receptors in the brain to constrict blood vessels and stop migraine pain
• Naproxen Sodium (500 mg) — An NSAID (nonsteroidal anti-inflammatory drug) that reduces inflammation and pain

By combining these two ingredients, Treximet attacks migraine through two different mechanisms at once. Learn more about how Treximet works.

Key Facts

• Generic name: Sumatriptan and Naproxen Sodium
• Drug class: Triptan/NSAID combination
• Manufacturer: Currax Pharmaceuticals LLC
• FDA approved: Yes, for acute treatment of migraine with or without aura in adults
• Controlled substance: No
• Generic available: Yes

What Is Treximet Used For?

Treximet is FDA-approved for one specific use: the acute treatment of migraine attacks with or without aura in adults.

This means it's designed to stop a migraine that's already started — it's not a preventive medication you take daily. You take it at the first sign of a migraine to relieve headache pain, nausea, and sensitivity to light and sound.

Some doctors may also prescribe it off-label for menstrual migraines. A pediatric formulation (10/60 mg) was previously available but has been discontinued.

What Treximet Is NOT Used For

• It is not for daily headache prevention
• It is not for tension headaches or cluster headaches
• It is not for hemiplegic or basilar migraines (these are contraindicated)

How Is Treximet Taken?

Treximet comes as an oral tablet. Here's how to take it:

1. Take 1 tablet at the first sign of a migraine
2. Swallow whole with water — do not split, crush, or chew
3. If needed, take a second tablet after at least 2 hours if the migraine returns or doesn't fully resolve
4. Maximum dose: 2 tablets per 24 hours

You don't need to take it with food, but having a small snack can help reduce nausea. Make sure you're well-hydrated before taking it, as dehydration can worsen both migraines and side effects.

Important Dosing Notes

• Do not use Treximet more than 10 days per month to avoid medication overuse headache
• Do not take other triptans or ergotamine medications within 24 hours of Treximet
• Do not take additional NSAIDs (like Ibuprofen or Aleve) while using Treximet — it already contains Naproxen Sodium

Who Should Not Take Treximet?

Treximet is not safe for everyone. You should not take Treximet if you have:

• A history of heart disease, angina, heart attack, or stroke
• Uncontrolled high blood pressure
• Peripheral vascular disease
• Hemiplegic or basilar migraine
• Severe liver or kidney disease
• A history of allergic reactions to Sumatriptan, Naproxen, Aspirin, or other NSAIDs
• Recently used another triptan or ergotamine medication (within 24 hours)
• Used an MAO inhibitor within the past 14 days
• Had recent CABG (coronary artery bypass graft) surgery

If you take SSRIs or SNRIs (antidepressants like Prozac, Zoloft, or Effexor), talk to your doctor about the risk of serotonin syndrome. Treximet is also not recommended in the third trimester of pregnancy.

For a full list of potential interactions, see our guide on Treximet drug interactions.

How Much Does Treximet Cost?

Treximet can be expensive, but you have options:

• Brand-name Treximet: $500–$900 for 9 tablets without insurance
• Generic (Sumatriptan/Naproxen Sodium): $130–$250 for 9 tablets with discount coupons
• Manufacturer direct purchase: $75 or less for the authorized generic, or $99 or less for brand-name, through treximet.com with free shipping

Insurance Coverage

Many insurance plans cover the generic version, but you may need prior authorization or step therapy (trying a standalone triptan first). Brand-name Treximet often requires prior authorization. Medicare Part D plans may cover the generic with varying copays.

Saving Money

Discount cards from GoodRx, SingleCare, and RxSaver can significantly reduce the cost of generic Treximet. The manufacturer's direct-purchase option at treximet.com is often the cheapest route. See our complete Treximet savings guide for all your options.

Side Effects at a Glance

Common side effects include dizziness, nausea, fatigue, chest tightness, and tingling. Serious but rare side effects include cardiovascular events and GI bleeding — Treximet carries two FDA boxed warnings for these risks. Read our detailed guide on Treximet side effects to learn what to watch for.

Final Thoughts

Treximet is a powerful, FDA-approved option for stopping migraines in their tracks. Its combination of Sumatriptan and Naproxen Sodium offers a two-pronged approach that many patients find more effective than either ingredient alone. While it's not right for everyone — especially people with heart disease or certain other conditions — it remains one of the most effective acute migraine treatments available.

If you have a prescription and need to find it in stock, use Medfinder to locate a pharmacy near you. And if you're still looking for a prescriber, check out our guide on how to find a doctor who can prescribe Treximet.