Comprehensive medication guide to Diclegis including estimated pricing, availability information, side effects, and how to find it in stock at your local pharmacy.
Estimated Insurance Pricing
$0–$30 copay for generic doxylamine/pyridoxine at Tier 1–2 on most commercial plans; brand-name Diclegis may require prior authorization with higher copays.
Estimated Cash Pricing
$286–$423 retail for brand-name Diclegis; generic doxylamine/pyridoxine available for as low as $45–$80 with a GoodRx or SingleCare coupon for a 60-tablet supply.
Medfinder Findability Score
78/100
On this page
Diclegis is a brand-name prescription medication containing doxylamine succinate 10 mg and pyridoxine hydrochloride (vitamin B6) 10 mg in a delayed-release tablet. It is manufactured by Duchesnay USA and received FDA approval in April 2013 as the only medication specifically indicated for nausea and vomiting of pregnancy (NVP) in the United States.
Diclegis carries FDA Pregnancy Category A status — the safest available classification — meaning controlled studies in pregnant women have not demonstrated increased risk to the fetus. The American College of Obstetricians and Gynecologists (ACOG) recommends pyridoxine with or without doxylamine as first-line pharmacotherapy for NVP.
A generic version — doxylamine succinate/pyridoxine hydrochloride delayed-release 10 mg/10 mg — is FDA-approved as therapeutically equivalent and available from multiple manufacturers including Par Health USA and Amneal. The active ingredients and delayed-release formulation are identical to brand-name Diclegis.
We have a 99% success rate finding medications, even during nationwide shortages.
Need this medication?
Diclegis works through two complementary mechanisms simultaneously. The doxylamine component is a first-generation antihistamine that crosses the blood-brain barrier and blocks H1 histamine receptors in the chemoreceptor trigger zone (CTZ) — the brainstem region that initiates vomiting — and in the vestibular system. By dampening these signals, doxylamine reduces nausea and the urge to vomit.
Pyridoxine (vitamin B6) contributes to NVP relief through its role in neurotransmitter synthesis — it is required for the production of serotonin, dopamine, and GABA, which regulate nausea signals and gut motility. Vitamin B6 levels often decrease in early pregnancy, and supplementation helps restore normal neurotransmitter function.
The delayed-release formulation ensures the tablet passes through the stomach to the small intestine before dissolving, providing a sustained therapeutic effect rather than immediate but brief relief. This is why Diclegis must be taken whole and on an empty stomach — breaking the tablet destroys the sustained-release benefit.
10 mg / 10 mg — delayed-release tablet
Starting dose: 2 tablets at bedtime. Maximum: 4 tablets/day (1 morning + 1 mid-afternoon + 2 bedtime). Take on empty stomach with full glass of water.
As of 2026, Diclegis is not on the FDA Drug Shortage Database or the ASHP shortage list. However, many patients still struggle to fill their prescriptions. The main barriers are low routine pharmacy stocking (Diclegis is ordered on demand at many locations), brand vs. generic inventory variability, insurance prior authorization delays for brand-name, and sticker shock at retail price.
The generic (doxylamine/pyridoxine 10 mg/10 mg delayed-release) is more widely available than brand-name Diclegis and is significantly cheaper with discount coupons. Most large chain pharmacies carry it or can order it within 1–3 business days. Independent pharmacies may also be able to source it quickly.
To find Diclegis in stock near you without calling pharmacies yourself, use medfinder — enter your medication and location and we'll find which pharmacies near you can fill your prescription.
Because Diclegis is not a DEA-scheduled controlled substance, any licensed prescriber with prescribing authority can prescribe it without special registration. There are no DEA requirements, special REMS programs, or additional certifications needed.
OB/GYNs — primary pregnancy care specialists; most common Diclegis prescribers
Certified Nurse Midwives (CNMs) — prescribe Diclegis for patients in midwifery-based prenatal care
Family practice / Internal medicine physicians — can prescribe especially in early pregnancy before first OB appointment
Nurse Practitioners (NPs) and Physician Assistants (PAs) — advanced practice providers with prescribing authority in most states
Telehealth is widely available for Diclegis. Because it is not a controlled substance, it can be prescribed via video or phone consultation on women's health telehealth platforms such as Nurx, Maven Clinic, and Teladoc Health in most states, making same-day or next-day consultations accessible from home.
No. Diclegis (doxylamine/pyridoxine) is not a federally scheduled controlled substance under the DEA Controlled Substances Act. It does not require a DEA registration number to prescribe, and it can be filled at any licensed pharmacy without the restrictions that apply to Schedule II–V medications.
Because Diclegis is not controlled, it can be prescribed via telehealth without an in-person visit in most states, which is particularly convenient for pregnant patients managing morning sickness. Refills are permitted as clinically indicated, though NVP typically resolves after the first trimester.
The most common side effects are related to the antihistamine (doxylamine) component:
Drowsiness/somnolence — most common; can be severe; take at bedtime to manage
Fatigue — general tiredness beyond typical pregnancy fatigue
Dry mouth — anticholinergic effect; stay hydrated
Dizziness — rise slowly from seated or lying positions
Severe allergic reaction — difficulty breathing, swelling of face/tongue; call 911
Eye pain or vision changes — may indicate increased intraocular pressure; especially important for patients with narrow-angle glaucoma
Urinary retention — difficulty urinating; anticholinergic effect
False positive drug screen — doxylamine can cause false positive tests for methadone, opiates, and PCP
Know what you need? Skip the search.
Bonjesta
Same active ingredients (doxylamine 20 mg/pyridoxine 20 mg) at double the dose in extended-release form. Requires 1–2 tablets/day vs. up to 4 for Diclegis. Brand-name only; no generic until 2033. Costs ~$481–$490 for 30 tablets.
Ondansetron (Zofran)
Serotonin 5-HT3 receptor antagonist used off-label for NVP. Second-line option when Diclegis fails. Generic available for $10–$30. Less sedating than doxylamine.
Promethazine (Phenergan)
First-generation antihistamine used off-label for NVP. Strong sedation — useful for severe nocturnal NVP. FDA Category C. Generic ~$5–$20.
Metoclopramide (Reglan)
Dopamine antagonist/prokinetic; speeds stomach emptying. Second- or third-line for NVP. Avoid prolonged use (>12 weeks) due to tardive dyskinesia risk. FDA Category B.
Prefer Diclegis? We can find it.
MAO Inhibitors (phenelzine, tranylcypromine, selegiline)
majorContraindicated. Intensify and prolong adverse CNS effects of doxylamine in a dangerous and potentially life-threatening way.
Alcohol
majorDramatically increases sedating effect. Avoid completely while taking Diclegis.
CNS depressants (benzodiazepines, opioids, muscle relaxers, sleep aids)
majorAdditive CNS depression; increased risk of severe sedation, respiratory depression, falls, and accidents.
Sodium oxybate (Xyrem)
majorProfound sedation, respiratory depression, coma, and death may result. Absolutely contraindicated combination.
Olopatadine intranasal (Patanase)
majorIncreased CNS depression risk. Avoid or use an alternate drug.
Cisplatin
moderatePyridoxine may decrease cisplatin effectiveness. Monitor closely.
Clarithromycin / Azithromycin
moderateMay decrease pyridoxine levels by altering intestinal flora, potentially reducing Diclegis efficacy.
Diclegis is the only FDA-approved treatment specifically for morning sickness in the United States and carries the strongest available pregnancy safety rating (Category A). Despite its high retail price, the generic version is accessible for $45–$80 with a discount coupon — making effective NVP treatment affordable for most patients.
Finding the medication at a pharmacy can sometimes require checking multiple locations, but it is not in an official shortage. The key steps are to ask for the generic, use a GoodRx or SingleCare coupon, and try multiple pharmacies including independents if chain pharmacies are out of stock.
If you're struggling to find Diclegis near you, medfinder calls pharmacies near you to find which ones have it in stock — so you can skip the phone tag and focus on feeling better.
Medfinder Editorial Standards
Our medication guides are researched and written to help patients make informed decisions. All content is reviewed for accuracy and updated regularly. Learn more about our standards
Real-time availability
Medfinder is actively checking pharmacy inventory for Diclegis. We don't publish a number until we have enough verified pharmacy checks to be accurate — start a search and our team confirms current availability near you, usually within 24 hours.
ChatGPT
Claude
Gemini