Comprehensive medication guide to {drug} including estimated pricing, availability information, side effects, and how to find it in stock at your local pharmacy.
Ondansetron is a prescription antiemetic medication used to prevent nausea and vomiting. It is FDA-approved for nausea and vomiting caused by cancer chemotherapy, radiation therapy, and surgery (postoperative nausea and vomiting). It is also widely prescribed off-label for morning sickness during pregnancy, gastroenteritis, and cyclic vomiting syndrome. Originally marketed under the brand name Zofran by GlaxoSmithKline, Ondansetron is now available as an affordable generic from multiple manufacturers including Teva, Mylan, Aurobindo, and Sandoz.
Ondansetron belongs to a class of drugs called 5-HT3 receptor antagonists. It works by selectively blocking serotonin 5-HT3 receptors in two key areas: the chemoreceptor trigger zone (CTZ) in the brain and the vagal nerve terminals in the gastrointestinal tract. By blocking these receptors, Ondansetron prevents nausea and vomiting signals from reaching the brain, providing effective relief without the heavy sedation associated with older antiemetic medications.
Ondansetron oral tablets and ODT are generally available at most pharmacies across the United States. However, the injectable (IV) formulation has experienced intermittent shortages since 2019 due to manufacturing delays and increased demand. Specific oral formulations like the ODT or certain strengths may occasionally have limited supply from particular manufacturers. With multiple generic manufacturers producing Ondansetron, prolonged shortages of the oral forms are uncommon. We give Ondansetron a findability score of 75 out of 100.
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Ondansetron can be prescribed by a wide range of healthcare providers. Oncologists commonly prescribe it for chemotherapy-induced nausea, while anesthesiologists use it to prevent postoperative nausea and vomiting. Emergency medicine physicians, gastroenterologists, OB/GYNs (for pregnancy-related nausea), primary care doctors, internists, pediatricians, and surgeons all regularly prescribe Ondansetron. It is also available through telehealth consultations.
No, Ondansetron is not a controlled substance. It has no DEA scheduling and does not carry a risk of abuse or dependence. It can be prescribed and refilled without the restrictions that apply to controlled medications.
Serious but rare side effects include QT prolongation (a heart rhythm abnormality), serotonin syndrome when combined with serotonergic drugs, and severe allergic reactions. Contact your doctor immediately if you experience chest pain, irregular heartbeat, or signs of an allergic reaction.
Ondansetron is one of the most commonly prescribed antiemetic medications in the United States and is generally easy to find at most pharmacies. Generic versions are highly affordable, often costing under $15 with a discount card. While the injectable formulation has seen intermittent shortages, oral tablets and ODT forms remain widely stocked. If you are having trouble locating Ondansetron at your local pharmacy, Medfinder can help you search nearby pharmacies that have it in stock.
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