What Is Diclegis? Uses, Dosage, and What You Need to Know in 2026

Diclegis is the only FDA-approved prescription medication specifically indicated for nausea and vomiting of pregnancy (NVP) in the United States. If your OB/GYN has just prescribed it — or if you're considering asking for it — here's everything you need to know in plain English.

What Is Diclegis?

Diclegis is a brand-name delayed-release tablet containing two active ingredients:

Doxylamine succinate 10 mg — an antihistamine that reduces nausea signals in the brain

Pyridoxine hydrochloride 10 mg — also known as vitamin B6, which plays a role in reducing nausea during pregnancy

It is manufactured by Duchesnay USA and received FDA approval in April 2013 — the first FDA-approved NVP treatment in over 30 years. Diclegis received FDA Pregnancy Category A status, the safest category, meaning controlled studies in pregnant women showed no increased risk to the fetus.

A generic version — doxylamine succinate/pyridoxine hydrochloride delayed-release 10 mg/10 mg — is also FDA-approved and available from multiple manufacturers.

What Is Diclegis Used For?

Diclegis is FDA-approved for one specific use: treating nausea and vomiting in pregnant women whose symptoms have not been adequately controlled with dietary and lifestyle changes. It is not approved for nausea in non-pregnant patients.

The American College of Obstetricians and Gynecologists (ACOG) recommends the combination of vitamin B6 (pyridoxine) with or without doxylamine as first-line pharmacotherapy for NVP. Diclegis provides both ingredients in a single delayed-release tablet for convenient, sustained relief.

What Is the Correct Diclegis Dosage?

Diclegis is dosed on a step-up schedule:

Day 1: Take 2 tablets at bedtime.

If symptoms are controlled: Continue 2 tablets at bedtime only.

If symptoms persist into Day 2 afternoon: Take 2 tablets at bedtime that night, then add 1 tablet in the morning on Day 3.

If symptoms still persist on Day 4: Take 1 tablet in the morning + 1 tablet mid-afternoon + 2 tablets at bedtime. Maximum: 4 tablets per day.

Important: Take Diclegis on an empty stomach — at least 1 hour before or 2 hours after a meal — with a full glass of water. Swallow tablets whole; do not crush, split, or chew them (breaking the tablet destroys the delayed-release coating).

How Is Diclegis Different from Bonjesta?

Both Diclegis and Bonjesta contain the same active ingredients (doxylamine + pyridoxine), but Bonjesta contains double the dose per tablet (20 mg each) in an extended-release (not just delayed-release) formulation. With Bonjesta, you take 1–2 tablets daily instead of up to 4. Bonjesta is brand-name only with no generic available; Diclegis has a generic. Both are FDA-approved for NVP.

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Is Diclegis Safe? Who Should Not Take It?

Diclegis is FDA Pregnancy Category A and has been studied in more pregnant women than virtually any other medication. However, it should NOT be taken by anyone who:

Is allergic to doxylamine, pyridoxine, or any inactive ingredient in Diclegis

Is taking MAO inhibitors (phenelzine, tranylcypromine, selegiline) — contraindicated, dangerous

Use with caution if you have narrow-angle glaucoma, urinary retention, peptic ulcer, or pyloroduodenal obstruction.

How Long Will I Need to Take Diclegis?

Nausea and vomiting of pregnancy typically peaks between weeks 8–10 and most commonly resolves by weeks 14–16 (end of the first trimester). Your provider will reassess whether you still need Diclegis as your pregnancy progresses. Some women need it into the second trimester, but this is less common.

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The Bottom Line

Diclegis is the gold-standard prescription treatment for morning sickness in the US — safe, effective, and ACOG-recommended. Take it as directed, don't break the tablets, and use a discount coupon to reduce the cost. For more detail on how Diclegis works in your body, see how Diclegis works. For side effect information, see Diclegis side effects.