Comprehensive medication guide to Dyanavel XR including estimated pricing, availability information, side effects, and how to find it in stock at your local pharmacy.
Estimated Insurance Pricing
$25–$75 copay with prior authorization; many plans require step therapy through generic Adderall XR or Vyvanse first.
Estimated Cash Pricing
$460–$590 for 30 tablets retail; eligible patients may pay as low as $25/month with the Tris Pharma Savings Card.
Medfinder Findability Score
45/100
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Dyanavel XR is a brand-name, extended-release amphetamine medication manufactured by Tris Pharma. It is FDA-approved for the treatment of Attention Deficit Hyperactivity Disorder (ADHD) in patients aged 6 years and older. Dyanavel XR is unique among ADHD stimulants because it is available as both an extended-release oral suspension (liquid) and extended-release tablets, making it a useful option for patients who have difficulty swallowing pills. It is a Schedule II controlled substance due to its potential for abuse and dependence.
Dyanavel XR contains amphetamine, a non-catecholamine sympathomimetic amine that acts as a central nervous system (CNS) stimulant. It works by into presynaptic neurons and increasing the release of these neurotransmitters into the space between neurons. This enhanced dopamine and norepinephrine signaling in the brain helps improve attention, focus, and impulse control in patients with ADHD. The extended-release formulation provides consistent symptom control throughout the day with once-daily dosing.
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Extended-release oral suspension — suspension
2.5 mg/mL
Extended-release tablets
5 mg, 10 mg, 15 mg, 20 mg
Dyanavel XR has a findability score of 45 out of 100, meaning it is frequently difficult to locate in stock. As a brand-name-only amphetamine product with no generic available, Dyanavel XR is affected by the broader ADHD stimulant shortage that has persisted since late 2022. DEA production quotas, increased demand for ADHD medications, and limited manufacturing capacity all contribute to ongoing supply challenges. While the DEA increased amphetamine production quotas in fall 2025, availability has not fully normalized. Patients may need to call multiple pharmacies or use Medfinder to locate Dyanavel XR in stock near them.
As a Schedule II controlled substance, Dyanavel XR must be prescribed by a licensed healthcare provider with DEA authorization. Common prescribing specialties include:
Telehealth providers may also prescribe Dyanavel XR, though DEA rules for controlled substance prescribing via telehealth may require an in-person evaluation.
Yes. Dyanavel XR is classified as a Schedule II (CII) controlled substance by the DEA. This is the most restrictive category for medications with accepted medical use, reflecting amphetamine's high potential for abuse, misuse, and addiction. Schedule II prescriptions cannot be called in to pharmacies in most states, cannot have refills, and require a new prescription each time. Patients should be monitored for signs of misuse or dependence during treatment.
Serious side effects may include sudden cardiac events in patients with pre-existing heart conditions, new or worsening psychiatric symptoms, serotonin syndrome, and peripheral vasculopathy (Raynaud's phenomenon). Contact your doctor immediately if you experience chest pain, shortness of breath, or unusual psychiatric symptoms.
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Adderall XR (Mixed Amphetamine Salts XR)
the most direct alternative with wide generic availability
Vyvanse (Lisdexamfetamine)
a prodrug amphetamine stimulant with lower abuse potential; generic now available
Adzenys XR-ODT (Amphetamine XR)
an orally disintegrating tablet bioequivalent to Adderall XR, ideal for patients who have difficulty swallowing
Mydayis (Mixed Amphetamine Salts Triple-Bead)
a triple-bead extended-release amphetamine capsule providing up to 16 hours of coverage
Prefer Dyanavel XR? We can find it.
MAOIs
moderateContraindicated within 14 days; risk of hypertensive crisis
Serotonergic drugs (SSRIs, SNRIs, TCAs, triptans, fentanyl, lithium, tramadol)
moderateIncreased risk of serotonin syndrome
CYP2D6 inhibitors (Paroxetine, Fluoxetine, Quinidine, Ritonavir)
moderateMay increase serotonin syndrome risk
Urinary alkalinizers (sodium bicarbonate, Acetazolamide)
moderateCan increase amphetamine levels; avoid
Urinary acidifiers (Ascorbic Acid/Vitamin C)
moderateMay decrease amphetamine effectiveness
Acidic foods and drinks (orange juice, Vitamin C supplements)
moderateMay reduce absorption
Dyanavel XR fills an important niche in ADHD treatment as one of the few extended-release amphetamine products available in liquid suspension form, making it especially valuable for children and adults who cannot swallow pills. However, with no generic available and the ongoing ADHD stimulant shortage, finding Dyanavel XR in stock can be a real challenge. If your pharmacy is out of stock, try using Medfinder to locate nearby pharmacies that have it available. Eligible commercially insured patients can also save significantly with the Tris Pharma Savings Card, potentially reducing their cost to as low as $25 per month. Talk to your prescriber about alternatives like generic Adderall XR or Vyvanse if availability remains an issue.
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