Cost Is One of the Biggest Barriers to Dyanavel XR Adherence

You've determined that Dyanavel XR is the right medication for your patient. Maybe they need the liquid formulation because they can't swallow pills. Maybe they've tried other stimulants and Dyanavel XR provides the best symptom control. But then they get to the pharmacy — and the price tag stops them cold.

At $460 to $590 per month without insurance, Dyanavel XR is one of the more expensive ADHD medications on the market. With no generic available as of 2026, cost is a real and frequent barrier to adherence. This guide is designed to help providers navigate the savings landscape so you can keep your patients on the medications that work for them.

What Your Patients Are Paying

Let's start with the numbers:

• Cash price (no insurance): $460–$590 for a 30-day supply of tablets (20 mg)
• With commercial insurance: Varies widely. Many plans require prior authorization (PA) and step therapy — typically requiring a trial of generic Adderall XR or generic Vyvanse first. Even with coverage, copays for brand-name stimulants can range from $50 to $150+.
• Medicare/Medicaid: Coverage varies by plan and state. Part D plans may cover Dyanavel XR but often at a higher tier. Medicaid coverage depends on the state formulary.

For a medication that patients need every month, these costs add up quickly — and they're a leading reason patients skip doses, split pills (which isn't always appropriate with extended-release formulations), or abandon treatment entirely.

Manufacturer Savings Programs

Tris Pharma Savings Card

Tris Pharma offers a manufacturer savings card that can reduce the patient's out-of-pocket cost to as little as $25 per month.

• Eligibility: Commercially insured patients
• Not eligible: Patients on government insurance (Medicare, Medicaid, Tricare, VA)
• How to enroll: Patients can visit trissavingscard.com or ask their pharmacist
• Provider tip: Keep savings card information in your EMR or print cards to hand out at appointments. Many patients don't know these programs exist unless you tell them.

This is the single most impactful cost-reduction tool for commercially insured patients. Make it part of your standard workflow when prescribing Dyanavel XR.

Coupon and Discount Card Programs

For patients paying cash or those whose insurance doesn't cover Dyanavel XR well, third-party discount programs can sometimes help — though savings on brand-name controlled substances vary:

• GoodRx — May show discounted prices at select pharmacies. Savings are typically more significant for generics but worth checking for brand-name products.
• SingleCare — Another discount card option. Patients can compare prices across pharmacies.
• RxSaver — Aggregates discount prices from multiple coupon providers.

For a brand-name product like Dyanavel XR with no generic, these cards may offer modest savings (10-20%) compared to the full cash price, but every dollar matters to patients struggling with affordability.

Patient Assistance Programs (PAPs)

For patients who are uninsured or significantly underinsured:

• Tris Pharma Patient Assistance: Patients experiencing financial hardship should contact Tris Pharma directly. While not widely publicized, many manufacturers offer compassionate-use or free-drug programs.
• NeedyMeds (needymeds.org): Comprehensive database of patient assistance programs, including those for Amphetamine products.
• RxAssist (rxassist.org): Another resource for identifying manufacturer and foundation-based assistance programs.
• RxHope (rxhope.com): Helps patients find and apply for PAPs.

These programs often require documentation of income and insurance status, but they can provide medication at no cost to qualifying patients.

Generic Alternatives and Therapeutic Substitution

When cost is the primary barrier and the patient doesn't specifically need Dyanavel XR's unique formulation (liquid suspension), consider therapeutic alternatives:

Generic Amphetamine Options

• Generic Adderall XR (Mixed Amphetamine Salts XR) — The most widely available generic stimulant. Extended-release capsules available in multiple strengths. Typically $30-$80/month with a coupon card.
• Generic Vyvanse (Lisdexamfetamine) — Generic became available in 2023. Prodrug with potentially smoother onset and lower abuse potential. Typically $30-$60/month generic.

Other Branded Alternatives

• Adzenys XR-ODT — Orally disintegrating tablet, also by Tris Pharma. Bioequivalent to Adderall XR. Good for patients who can't swallow capsules but can handle an ODT.
• Mydayis — Triple-bead extended-release mixed Amphetamine salts. Up to 16 hours of coverage. Brand-only, so also expensive.

Non-Amphetamine Alternatives

If Amphetamine products are cost-prohibitive or unavailable:

• Generic Methylphenidate ER (Concerta, Ritalin LA generics) — Different stimulant class, widely available, generally affordable.
• Strattera (Atomoxetine) generic — Non-stimulant ADHD medication. No abuse potential. Affordable generic available.
• Guanfacine ER (Intuniv generic) — Non-stimulant option, often used as adjunct therapy.

For a comprehensive comparison, see our alternatives to Dyanavel XR guide.

When making a therapeutic switch, document the clinical rationale and discuss expectations with the patient. Switching stimulant formulations isn't always seamless — dose equivalence isn't one-to-one, and patients may notice differences in onset, duration, and side effect profile.

Building Cost Conversations into Your Workflow

Cost should be part of every prescribing decision, not an afterthought. Here's how to integrate it:

At the Point of Prescribing

• Ask about insurance coverage before writing the prescription. "Do you know if your insurance covers Dyanavel XR?" can save a patient a wasted trip to the pharmacy.
• Mention the savings card proactively. Don't wait for the patient to ask about cost. Hand them the Tris Pharma savings card info along with the prescription.
• Check formulary status if your EMR or e-prescribing system supports it. Prior authorization requirements are common for Dyanavel XR — knowing this upfront lets you start the PA process before the patient leaves your office.

Prior Authorization Best Practices

Many insurance plans require PA for Dyanavel XR and may demand step therapy documentation. To streamline the process:

• Document prior medication trials (drug name, dose, duration, reason for discontinuation) in the chart
• Use the specific clinical rationale for Dyanavel XR — liquid formulation need, prior treatment failures, specific tolerability advantages
• Submit PA as early as possible to minimize gaps in treatment
• Have staff follow up within 48-72 hours if no response

At Follow-Up Visits

• Ask about adherence. If a patient is missing doses, cost is often the reason. "Are you having any trouble affording your medication?" opens the door.
• Reassess the need for brand. If the patient has been stable on Dyanavel XR and no longer specifically needs the liquid formulation, a switch to a generic alternative could save them hundreds per month.
• Update savings card enrollment. Insurance changes (new job, new plan year) may affect eligibility. Make sure patients re-enroll as needed.

Using Medfinder to Help Patients Find Dyanavel XR

Beyond cost, availability is the other major barrier. The ongoing amphetamine shortage means patients may struggle to fill their prescriptions even when they can afford them. Medfinder for Providers can help your practice direct patients to pharmacies that currently have Dyanavel XR in stock.

Consider:

• Adding Medfinder to your patient handouts and discharge instructions
• Training front-desk staff to mention Medfinder when patients call about prescription fills
• Using Medfinder to verify availability before sending a prescription to a specific pharmacy

Final Thoughts

Dyanavel XR is an effective ADHD medication with a unique liquid formulation — but its cost can be a significant barrier to patient adherence. By proactively discussing savings options, leveraging the Tris Pharma savings card, considering therapeutic alternatives when appropriate, and building cost conversations into your standard workflow, you can help ensure your patients stay on the treatment that works for them.

For more provider resources, visit Medfinder for Providers and see our full provider's guide to finding Dyanavel XR in stock.