Dyanavel XR Drug Interactions You Need to Know About

When you take Dyanavel XR for ADHD, it's important to know which other medications, supplements, and even foods can interact with it. Some interactions are dangerous. Others can make Dyanavel XR less effective — or more potent than expected.

This guide covers the major and moderate drug interactions for Dyanavel XR based on FDA prescribing information, so you know exactly what to tell your doctor and pharmacist.

How Drug Interactions Work

A drug interaction happens when one substance changes how another substance works in your body. Interactions can:

• Increase side effects — One drug may amplify the effects of another, raising the risk of serious reactions.
• Reduce effectiveness — One drug may decrease how well another drug works.
• Create new risks — The combination of two drugs may cause a reaction that neither would cause alone.

Dyanavel XR contains Amphetamine, a CNS stimulant that affects dopamine and norepinephrine in the brain. Because of how it works, it interacts with several categories of medications.

Major Drug Interactions (Avoid or Use Extreme Caution)

MAOIs (Monoamine Oxidase Inhibitors)

This is the most dangerous interaction. Taking Dyanavel XR with an MAOI — or within 14 days of stopping one — can cause a hypertensive crisis (a sudden, dangerous spike in blood pressure that can lead to stroke or death).

MAOIs include:

• Phenelzine (Nardil)
• Tranylcypromine (Parnate)
• Isocarboxazid (Marplan)
• Selegiline (Emsam, Zelapar)
• Linezolid (Zyvox) — an antibiotic that also has MAOI activity

Dyanavel XR is contraindicated within 14 days of MAOI use. Make sure every doctor and pharmacist you see knows if you've recently taken an MAOI.

Serotonergic Drugs (Risk of Serotonin Syndrome)

Combining Dyanavel XR with drugs that increase serotonin levels raises the risk of serotonin syndrome — a potentially life-threatening condition with symptoms including agitation, confusion, rapid heart rate, high blood pressure, dilated pupils, muscle twitching, high fever, and seizures.

Serotonergic medications that interact with Dyanavel XR include:

• SSRIs: Fluoxetine (Prozac), Sertraline (Zoloft), Paroxetine (Paxil), Citalopram (Celexa), Escitalopram (Lexapro)
• SNRIs: Venlafaxine (Effexor), Duloxetine (Cymbalta), Desvenlafaxine (Pristiq)
• Tricyclic antidepressants (TCAs): Amitriptyline, Nortriptyline (Pamelor), Imipramine (Tofranil)
• Triptans: Sumatriptan (Imitrex), Rizatriptan (Maxalt) — used for migraines
• Opioids: Fentanyl, Tramadol
• Others: Lithium, Buspirone (Buspar), Tryptophan supplements

Many people with ADHD also take antidepressants. If you're prescribed both Dyanavel XR and an SSRI or SNRI, your doctor should monitor you closely for signs of serotonin syndrome. Do not stop any medication without talking to your doctor first.

CYP2D6 Inhibitors

Certain medications inhibit the CYP2D6 enzyme in your liver, which can increase Amphetamine's serotonin-related effects and raise the risk of serotonin syndrome. These include:

• Paroxetine (Paxil)
• Fluoxetine (Prozac)
• Quinidine
• Ritonavir (Norvir)

Moderate Drug Interactions

Urinary Alkalinizers

Substances that make your urine more alkaline (less acidic) can increase Amphetamine levels in your blood by reducing how quickly your kidneys eliminate it. This can lead to stronger effects and more side effects. Avoid:

• Sodium bicarbonate (baking soda, some antacids)
• Acetazolamide (Diamox)

Urinary Acidifiers

The opposite effect: substances that make your urine more acidic can decrease Amphetamine levels, making Dyanavel XR less effective. These include:

• Ascorbic acid (Vitamin C) in large doses
• Ammonium chloride

Tricyclic Antidepressants (TCAs)

Amphetamines may increase the effects of TCAs like Amitriptyline and Nortriptyline. Your doctor may need to adjust your TCA dose if you're also taking Dyanavel XR.

Sympathomimetic Drugs

Other stimulant-like medications — including decongestants like Pseudoephedrine (Sudafed) and some weight-loss medications — can have additive cardiovascular effects when combined with Dyanavel XR. This means higher risk of increased heart rate, elevated blood pressure, and other cardiovascular issues.

Supplements and OTC Products to Watch

• Vitamin C (Ascorbic Acid) — Large doses can reduce Dyanavel XR effectiveness by acidifying urine. Don't take high-dose Vitamin C supplements around the same time as your medication.
• Tryptophan — This supplement (often taken for sleep) increases serotonin and raises the risk of serotonin syndrome when combined with Dyanavel XR.
• Decongestants — Over-the-counter cold medicines containing Pseudoephedrine or Phenylephrine can increase cardiovascular strain when combined with stimulants.
• Caffeine — While not a formal drug interaction, caffeine is also a stimulant. Combining it with Dyanavel XR can increase anxiety, insomnia, and heart rate.

Food and Drink Interactions

• Acidic foods and drinks — Orange juice, grapefruit juice, soda, and other acidic beverages can reduce Amphetamine absorption and effectiveness if consumed around the time of dosing. Try to avoid them within an hour of taking your medication.
• Alkaline foods — While less commonly discussed, highly alkaline foods could theoretically increase Amphetamine absorption. This is rarely a practical concern but worth mentioning.
• Alcohol — Although not a listed interaction, combining alcohol with stimulants can mask the signs of intoxication, leading to dangerous overconsumption. Avoid alcohol while taking Dyanavel XR.

What to Tell Your Doctor

Before starting Dyanavel XR, make sure your doctor knows about:

• All prescription medications you take — especially antidepressants (SSRIs, SNRIs, TCAs), MAOIs, triptans, and opioids
• Over-the-counter medications — including cold and flu medicines, antacids, and pain relievers
• Supplements — especially Vitamin C, Tryptophan, and St. John's Wort
• Caffeine intake — how much coffee, tea, energy drinks, or caffeinated soda you consume daily
• Any history of heart problems — stimulant interactions can be more dangerous in patients with cardiac conditions

Every time you start a new medication, remind your doctor and pharmacist that you take Dyanavel XR. This applies to dental procedures and urgent care visits too — any prescriber needs to know.

Final Thoughts

Dyanavel XR interacts with more medications than many people realize — including common antidepressants, cold medicines, and even Vitamin C. The most dangerous interaction is with MAOIs, which is an absolute contraindication. For most other interactions, the key is communication: keep your doctor and pharmacist informed about everything you take.

If you're looking for Dyanavel XR at your pharmacy, Medfinder can help you find it in stock near you.