Comprehensive medication guide to {drug} including estimated pricing, availability information, side effects, and how to find it in stock at your local pharmacy.
Amphetamine/Dextroamphetamine XR (brand name Adderall XR) is a central nervous system (CNS) stimulant prescribed primarily for the treatment of Attention Deficit Hyperactivity Disorder (ADHD) in patients aged 6 and older. It contains a combination of four amphetamine salts — dextroamphetamine sulfate, amphetamine sulfate, dextroamphetamine saccharate, and amphetamine aspartate monohydrate — in a 3:1 ratio of dextro- to levo-amphetamine.
The extended-release formulation uses two types of beads (immediate-release and delayed-release) to provide symptom control throughout the day with a single morning dose. It is one of the most widely prescribed ADHD medications in the United States.
Amphetamine/Dextroamphetamine XR works by blocking the reuptake of norepinephrine and dopamine into presynaptic neurons while simultaneously increasing their release into the space between neurons. This results in higher concentrations of these neurotransmitters in the brain, which improves focus, attention, and impulse control in patients with ADHD.
The extended-release capsule contains two types of drug-releasing beads: one that releases medication immediately and another that releases medication approximately four hours later. This dual-release mechanism provides up to 12 hours of symptom coverage from a single morning dose.
Amphetamine/Dextroamphetamine XR is available as extended-release capsules in the following strengths:
Capsules can be swallowed whole or opened and sprinkled on applesauce for patients who have difficulty swallowing. Do not chew the beads.
Amphetamine/Dextroamphetamine XR has a findability score of 35 out of 100, meaning it is quite difficult to find in stock at most pharmacies. An ongoing nationwide shortage that began in October 2022 continues to affect supply into 2026. The 15 mg, 25 mg, and 30 mg strengths are particularly hard to find, with manufacturers reporting back orders and estimated availability in late February 2026. DEA production quotas were increased in October 2025, but high demand and supply chain disruptions have kept certain strengths intermittently unavailable.
If your pharmacy is out of stock, try using Medfinder to locate pharmacies near you that currently have your dose available. Calling independent pharmacies and asking your doctor about dose flexibility can also help.
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As a Schedule II controlled substance, Amphetamine/Dextroamphetamine XR requires a prescription from a licensed medical provider with DEA registration. Common prescribing specialties include:
Telehealth providers can also prescribe Amphetamine/Dextroamphetamine XR, though some states have additional requirements for controlled substance prescriptions via telemedicine.
Yes, Amphetamine/Dextroamphetamine XR is classified as a Schedule II controlled substance by the DEA. This is the highest schedule for medications with accepted medical use and reflects the drug's significant potential for abuse and physical or psychological dependence.
Because of its Schedule II classification:
The most frequently reported side effects of Amphetamine/Dextroamphetamine XR include:
Serious side effects are rare but may include sudden cardiac events in patients with structural heart abnormalities, psychiatric reactions (psychosis, mania), and peripheral vasculopathy. Contact your doctor immediately if you experience chest pain, shortness of breath, or hallucinations.
If you're unable to find Amphetamine/Dextroamphetamine XR in stock, or if your doctor recommends a different option, these alternatives may be worth discussing:
Amphetamine/Dextroamphetamine XR has several important drug interactions to be aware of:
Additionally, acidic foods and drinks such as orange juice and vitamin C supplements may decrease absorption. Always inform your doctor and pharmacist of all medications and supplements you take.
Amphetamine/Dextroamphetamine XR remains one of the most effective and widely prescribed treatments for ADHD, but the ongoing shortage that began in 2022 continues to make it challenging to find in stock. With a findability score of just 35 out of 100, patients often need to check multiple pharmacies or try different strengths.
Generic versions are affordable with discount coupons — as low as $28 per month through SingleCare — but finding a pharmacy with stock is the bigger challenge. Use Medfinder to search for pharmacies near you that currently have Amphetamine/Dextroamphetamine XR available. If your usual dose is unavailable, talk to your doctor about dose adjustments or alternative medications like Vyvanse or Concerta.
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