Xofluza 80 Mg Dose Pack Shortage: The 2026 Update

If you've been prescribed Xofluza 80 Mg Dose Pack and your pharmacy told you it's out of stock, you're not alone. During flu season, patients across the country have reported difficulty finding this medication. But is it actually in shortage, or is something else going on?

In this article, we'll break down the current availability of Xofluza, explain why it can be hard to find, and give you practical steps to get the treatment you need — fast.

Is Xofluza 80 Mg Dose Pack Still in Shortage?

As of early 2026, Xofluza is not listed as formally in shortage by the FDA. That's the official answer. But the real-world picture is more complicated.

Xofluza availability tends to fluctuate with flu season. During peak months — typically December through February — demand for antiviral medications surges. Because Xofluza is a brand-name drug with no generic version, supply can get stretched thin at individual pharmacies even when the overall national supply is adequate.

This means your local pharmacy might be out of stock even though a pharmacy across town has it on the shelf. It's not a manufacturing shortage — it's a distribution and demand problem.

Why Is Xofluza So Hard to Find?

Several factors contribute to the difficulty patients have finding Xofluza 80 Mg Dose Pack:

• Seasonal demand spikes. Flu season creates a surge in prescriptions. Pharmacies that stock limited quantities can run out quickly.
• No generic available. Unlike Tamiflu (which is available as generic oseltamivir), Xofluza has no generic equivalent. This limits the supply chain to a single manufacturer — Genentech.
• Pharmacy stocking decisions. Many pharmacies don't keep large quantities of Xofluza on hand because it's expensive and has a relatively short shelf life. They may stock Tamiflu instead.
• Weight-based dosing. The 80 mg dose pack is only for patients weighing 80 kg or more. Some pharmacies stock only the 40 mg version, which serves a larger patient population.

For a deeper look at the factors behind Xofluza availability, read our article on why Xofluza is so hard to find.

What Does Xofluza Cost in 2026?

The cash price for Xofluza 80 Mg Dose Pack without insurance typically ranges from $200 to $280, depending on the pharmacy. That's for a single dose — one pill.

If you have commercial insurance, your out-of-pocket cost may be much lower. However, some insurance plans require prior authorization or step therapy (trying Tamiflu first) before they'll cover Xofluza.

There are also savings options available:

• Manufacturer coupon: Eligible commercially insured patients may pay as little as $35 (up to $70 off).
• Direct-to-patient program: Genentech offers a $50 cash pay option through select pharmacies including Alto Pharmacy, Amazon Pharmacy, and Cost Plus Drugs.
• Patient assistance: The Genentech Patient Foundation may help uninsured or underinsured patients. Call 1-877-GENENTECH (436-3683).

Learn more in our full guide on how to save money on Xofluza.

Are There New Options in 2026?

As of 2026, there is still no generic version of Xofluza (baloxavir marboxil) available in the United States. Genentech holds the patent, and no generic manufacturers have announced plans to produce it in the near term.

However, the antiviral landscape continues to evolve. The same class of FDA-approved flu treatments remains available:

• Tamiflu (oseltamivir) — oral, twice daily for 5 days, generic available ($30–$60)
• Relenza (zanamivir) — inhaled, twice daily for 5 days
• Rapivab (peramivir) — single IV dose at a medical facility

If Xofluza isn't available, these alternatives can treat the flu effectively. See our complete alternatives guide for details.

How to Find Xofluza 80 Mg Dose Pack in Stock

If you've been prescribed Xofluza and your pharmacy doesn't have it, here's what to do:

1. Use MedFinder. MedFinder helps you search for pharmacies that currently have Xofluza in stock in your area. It's one of the fastest ways to check availability.
2. Call nearby pharmacies. Don't just call one — try at least 3–5 pharmacies within your area. Independent pharmacies sometimes have stock that chain pharmacies don't.
3. Ask about the 40 mg tablets. If the 80 mg dose pack isn't available, your pharmacist may be able to dispense two 40 mg tablets instead (with your doctor's approval).
4. Try mail-order or online pharmacies. Amazon Pharmacy and Cost Plus Drugs both participate in Genentech's direct-to-patient program and may have Xofluza available for $50.
5. Act fast. Xofluza must be taken within 48 hours of symptom onset. If you can't find it quickly, ask your doctor to switch to Tamiflu or another alternative.

For step-by-step instructions, check out our guide on how to find Xofluza in stock near you.

Final Thoughts

Xofluza 80 Mg Dose Pack is not in a formal shortage in 2026, but it can still be difficult to find at your local pharmacy — especially during peak flu season. The lack of a generic version, seasonal demand surges, and pharmacy stocking decisions all play a role.

The most important thing is to start flu treatment within 48 hours of your first symptoms. If you can find Xofluza, great. If not, effective alternatives like Tamiflu are widely available. Don't let a stock issue delay your treatment.

Use MedFinder to check real-time availability, and talk to your doctor about the best option for your situation.