Having trouble finding Xofluza 80 Mg Dose Pack at your pharmacy? Learn why this flu medication is hard to find in 2026 and what you can do about it.
You've got the flu, your doctor just called in a prescription for Xofluza 80 Mg Dose Pack, and your pharmacy says they don't have it. Sound familiar? You're not alone — many patients across the country have run into this exact problem, especially during flu season.
Xofluza (Baloxavir Marboxil) is one of the most effective flu treatments available. It works with just a single dose, making it incredibly convenient compared to older flu medications. But that convenience comes with a catch: it can be surprisingly difficult to track down when you need it most.
In this article, we'll explain what Xofluza 80 Mg Dose Pack is, why it's hard to find, and — most importantly — what you can do to get your prescription filled quickly.
Xofluza is a prescription antiviral medication used to treat influenza (the flu). Its generic name is Baloxavir Marboxil, and it's made by Genentech, a member of the Roche Group. It was first approved by the FDA in October 2018.
What makes Xofluza unique is its single-dose treatment. Unlike Tamiflu (Oseltamivir), which requires taking pills twice a day for five days, Xofluza works with just one dose taken by mouth. The 80 mg dose pack is prescribed for patients who weigh 80 kg (about 176 pounds) or more.
Xofluza is approved for:
To learn more about how this medication works, check out our guide on how Xofluza 80 Mg Dose Pack works.
There are several reasons why you might have trouble finding Xofluza 80 Mg Dose Pack at your local pharmacy. Here are the most common ones:
Flu season typically runs from October through March, with peak activity in January and February. During these months, demand for antiviral medications like Xofluza spikes dramatically. The 2024-2025 flu season was the most severe in seven years, with an estimated 47 to 82 million illnesses across the United States according to the CDC. That kind of demand can quickly overwhelm pharmacy supply chains.
Since Xofluza is a single-dose medication, pharmacies don't always stock large quantities — they may only keep a few dose packs on hand at any given time.
Many large chain pharmacies prioritize stocking Tamiflu (Oseltamivir), which has been the go-to flu treatment for decades and is now available as a cheaper generic. Because Xofluza is a brand-name medication with a higher price point (around $200 to $280 without insurance), some pharmacies carry limited stock or don't carry the 80 mg dose pack at all.
This is especially true for the 80 mg strength, which is only prescribed for patients weighing 80 kg or more — a smaller subset of the overall patient population.
As of 2026, there is no generic version of Xofluza (Baloxavir Marboxil). This means there's only one manufacturer supplying the medication, and pharmacies can't substitute a cheaper alternative. The lack of a generic also means that insurance companies may impose restrictions like prior authorization or step therapy, which can further complicate access.
Even when Genentech produces enough Xofluza to meet demand, getting it to every pharmacy at the right time is a logistical challenge. Rural pharmacies and smaller independent pharmacies may receive shipments less frequently than large urban chains. When flu season hits hard and fast, the distribution system can struggle to keep up.
The good news is that there are several steps you can take to improve your chances of finding Xofluza 80 Mg Dose Pack in stock:
Medfinder helps you search for medications at pharmacies near you. Instead of calling pharmacy after pharmacy, you can check availability online and save valuable time — which matters a lot when you're sick with the flu and the 48-hour treatment window is ticking.
Independent and specialty pharmacies often have different supply chains than large chains like CVS or Walgreens. They may be more willing to order Xofluza quickly or may already have stock that larger pharmacies don't. Don't overlook these smaller pharmacies in your search.
In October 2025, Genentech launched a Direct-to-Patient program that offers Xofluza through select pharmacies including Alto Pharmacy, Amazon Pharmacy, and Mark Cuban Cost Plus Drug Company. Through this program, eligible patients can get Xofluza for as little as $50 cash pay — about 70% less than the list price. Same-day delivery is available in select markets.
If your usual pharmacy doesn't have Xofluza 80 Mg Dose Pack, ask them to check other locations in their network. Many chain pharmacies can transfer prescriptions between stores. You can also ask your doctor to send the prescription to a pharmacy that's more likely to have it in stock.
For a detailed step-by-step guide, read our article on how to find Xofluza 80 Mg Dose Pack in stock near you.
If you absolutely cannot find Xofluza and time is running out on your 48-hour window, talk to your doctor about alternatives. Oseltamivir (Tamiflu) is widely available as a generic, and Peramivir (Rapivab) is a single-dose option given as an IV infusion. Our article on alternatives to Xofluza 80 Mg Dose Pack covers your options in detail.
Finding Xofluza 80 Mg Dose Pack can be frustrating, especially when you're feeling awful and need treatment fast. The combination of seasonal demand, limited pharmacy stocking, and no generic option means that this medication isn't always sitting on the shelf when you need it.
But you have options. Tools like Medfinder can help you locate pharmacies with stock nearby, and Genentech's savings programs can make the medication more affordable. The key is to act quickly — Xofluza works best when taken within 48 hours of your first symptoms.
If you're also concerned about the cost of Xofluza, be sure to check out our guide on how to save money on Xofluza 80 Mg Dose Pack.
You focus on staying healthy. We'll handle the rest.
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