Comprehensive medication guide to {drug} including estimated pricing, availability information, side effects, and how to find it in stock at your local pharmacy.
Lyllana is a brand-name estradiol transdermal patch manufactured by Amneal Pharmaceuticals. It delivers estradiol — the primary form of estrogen — through the skin to treat moderate to severe menopausal symptoms such as hot flashes and night sweats. Lyllana is also approved for the prevention of postmenopausal osteoporosis.
The patch is applied twice weekly (every 3–4 days) to the lower abdomen or buttocks, providing a steady release of estradiol to help restore declining estrogen levels during and after menopause.
Lyllana delivers 17β-estradiol transdermally through the skin directly into the bloodstream. Once absorbed, estradiol binds to estrogen receptors throughout the body, restoring estrogen levels that naturally decline during menopause. By replenishing estrogen, Lyllana reduces vasomotor symptoms like hot flashes and night sweats, and helps maintain bone density to prevent osteoporosis.
Estradiol also modulates the pituitary gland's secretion of gonadotropins (LH and FSH) through negative feedback, which helps stabilize the hormonal fluctuations responsible for menopausal symptoms. Transdermal delivery bypasses the liver's first-pass metabolism, which may reduce certain risks compared to oral estrogen.
Your doctor will typically start you on 0.0375 mg/day for vasomotor symptoms (hot flashes) or 0.025 mg/day for osteoporosis prevention, adjusting as needed.
Lyllana has a findability score of 40 out of 100, meaning it is currently difficult to find. As of early 2026, estradiol patch shortages continue to affect multiple brands including Lyllana. Major pharmacies like CVS and Optum have reported backorders and difficulty filling prescriptions. The shortage stems from limited manufacturers, global raw material constraints, and a surge in demand after the FDA removed the black box warning from HRT in November 2025.
If your pharmacy is out of stock, ask your pharmacist to check other estradiol patch brands like Climara, Vivelle-Dot, or Dotti, which contain the same active ingredient. Medfinder can help you locate pharmacies that currently have Lyllana or its equivalents in stock.
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Lyllana is most commonly prescribed by:
Telehealth services also prescribe Lyllana, making it easier to get a prescription if you don't have a local specialist.
No, Lyllana is not a controlled substance. It is not classified under any DEA schedule. However, it does require a prescription from a licensed healthcare provider. Because Lyllana is not a controlled substance, it can be prescribed via telehealth and is eligible for standard mail-order pharmacy fulfillment.
Most side effects of Lyllana are mild and tend to improve as your body adjusts. Common side effects include:
Serious but rare side effects include blood clots (DVT, pulmonary embolism), stroke, heart attack, and increased risk of breast or endometrial cancer with long-term use. Contact your doctor immediately if you experience sudden chest pain, shortness of breath, severe headache, or vision changes.
If you cannot find Lyllana in stock, several alternatives deliver the same active ingredient (estradiol) via transdermal patch:
Talk to your doctor about switching brands — most estradiol patches are therapeutically equivalent and can be substituted.
Lyllana can interact with several medications and substances:
Always tell your doctor about all medications, supplements, and herbal products you're taking before starting Lyllana.
Lyllana is an effective estradiol transdermal patch for managing menopausal symptoms and preventing osteoporosis. However, the ongoing estradiol patch shortage makes it challenging to find in 2026. With a findability score of just 40 out of 100, patients may need to try multiple pharmacies or consider equivalent alternatives like Climara, Vivelle-Dot, or Dotti.
If you're struggling to find Lyllana, Medfinder can help you locate pharmacies with current stock. Generic estradiol patches are significantly cheaper ($29–$55 vs. $150–$210 for brand-name) and are therapeutically equivalent, so ask your doctor about generic options to save money and improve your chances of finding it in stock.
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