What Is Lyllana?

Lyllana is a brand-name prescription estradiol transdermal patch made by Amneal Pharmaceuticals. It delivers estradiol — the most potent naturally occurring form of estrogen — through your skin and into your bloodstream.

Estradiol is the same hormone your ovaries produce before menopause. When your body stops making enough of it during and after menopause, you may experience hot flashes, night sweats, and other symptoms. Lyllana replaces that lost estrogen to help manage those symptoms.

To understand the science behind how it works, see our mechanism of action guide.

What Is Lyllana Used For?

The FDA has approved Lyllana for two uses:

1. Treatment of moderate to severe vasomotor symptoms due to menopause — This means hot flashes and night sweats that are frequent or intense enough to affect your daily life.
2. Prevention of postmenopausal osteoporosis — Estrogen helps maintain bone density. Lyllana can be used to slow bone loss in women after menopause, though other medications may be tried first.

Lyllana is sometimes used off-label for other purposes, including hormone therapy in transgender women and treatment of low estrogen caused by premature ovarian insufficiency. These uses should be managed by a specialist.

Lyllana Dosage Options

Lyllana comes in five patch strengths:

• 0.025 mg/day — Lowest dose, typically used for osteoporosis prevention
• 0.0375 mg/day — Common starting dose for hot flashes and night sweats
• 0.05 mg/day — Standard dose for moderate symptoms
• 0.075 mg/day — Higher dose for more severe symptoms
• 0.1 mg/day — Highest available dose

Your doctor will start you on the lowest effective dose and adjust as needed. The goal is to use the smallest amount of estrogen that controls your symptoms.

How to Apply Lyllana

Lyllana is a twice-weekly patch, meaning you change it every 3 to 4 days. Here's how to apply it correctly:

1. Choose your spot — Apply to clean, dry skin on your lower abdomen (below the belly button) or buttocks. Never apply to your breasts.
2. Prepare the skin — Don't use lotions, oils, or powders on the area. The skin should be free of cuts, rashes, or irritation.
3. Apply and press — Remove the protective liner and press the patch firmly against your skin for at least 10 seconds. Make sure the edges stick well.
4. Rotate sites — Use a different spot each time. Wait at least 1 week before reusing the same area. This helps prevent skin irritation.
5. Remove carefully — When it's time to change your patch, peel off the old one slowly. Fold it in half (sticky sides together) and dispose of it safely away from children and pets.

Who Should Not Use Lyllana?

Lyllana is not right for everyone. You should not use Lyllana if you have:

• Undiagnosed abnormal vaginal bleeding
• Known or suspected breast cancer, or a history of breast cancer
• Active or history of blood clots (deep vein thrombosis, pulmonary embolism)
• Active or history of stroke or heart attack
• Liver disease or liver impairment
• A known allergy to estradiol or any component of the Lyllana patch
• A known blood clotting disorder (protein C, protein S, or antithrombin deficiency)

If you have a uterus, you must take a progestogen alongside Lyllana to reduce the risk of endometrial cancer. Your doctor will prescribe this for you.

Important Safety Information

Lyllana carries an FDA boxed warning — the most serious type of safety alert. Key risks include:

• Increased risk of endometrial cancer (when used without progestogen)
• Increased risk of stroke and blood clots
• Increased risk of breast cancer with long-term combined estrogen-progestogen use
• Increased risk of probable dementia in women 65 and older

These risks are generally low for healthy women under 60 who are within 10 years of menopause onset. Your doctor will weigh the benefits against the risks for your specific situation.

For a detailed look at side effects, read our Lyllana side effects guide. For drug interaction information, see Lyllana drug interactions.

Lyllana vs. Other Estradiol Patches

Lyllana is one of several estradiol patch brands on the market. All contain the same active ingredient (estradiol) and work the same way. The main differences are the manufacturer and patch design:

• Climara — Once-weekly patch by Bayer (less frequent changes)
• Vivelle-Dot — Twice-weekly patch by Noven (one of the most widely prescribed)
• Dotti — Twice-weekly generic patch
• Minivelle — Smaller twice-weekly patch

If Lyllana is unavailable due to the current shortage, your doctor can switch you to any of these alternatives with the same active ingredient.

How Much Does Lyllana Cost?

Brand-name Lyllana costs $150–$210 per month without insurance for a supply of 8 patches. Generic estradiol patches are significantly cheaper at $29–$55 per month with a discount card.

Most insurance plans cover generic estradiol patches with copays of $10–$30. Brand-name Lyllana may require prior authorization.

For ways to save, see our savings guide with coupons and patient assistance programs.

Finding Lyllana in 2026

Lyllana and other estradiol patches are currently in short supply nationwide. If you need help finding it, use MedFinder to check pharmacy stock near you in real time.