Lyllana and Estradiol patches are in shortage in 2026. Get the latest update on availability, pricing, alternatives, and how to find stock.
If you rely on Lyllana for managing menopause symptoms, you've likely experienced the frustration firsthand: pharmacies telling you the medication is backordered, out of stock, or unavailable with no estimated date for return. This isn't a minor blip — it's a widespread, ongoing shortage affecting Lyllana and Estradiol patches across the United States.
This article is your up-to-date guide to understanding the shortage, what it means for your treatment, and what you can do about it right now.
Yes. As of early 2026, Lyllana remains in shortage across the country. Major pharmacies including CVS and Optum mail-order have reported inability to fill Lyllana prescriptions. The shortage is not limited to Lyllana — multiple Estradiol patch brands are affected, making the entire category difficult to find.
The shortage has been ongoing since late 2024 and worsened throughout 2025. There is no confirmed date for when full supply will be restored.
Several factors are driving the shortage simultaneously:
Only a small number of companies produce Estradiol patches in the US — Amneal (Lyllana), Noven (Vivelle-Dot), Sandoz, Mylan, and Zydus. This concentrated manufacturing base means a disruption at any one company ripples across the entire supply.
The raw materials needed for Estradiol patch production have been in limited supply worldwide. This is affecting manufacturers in the US, Europe, Australia, and New Zealand simultaneously.
In November 2025, the FDA removed the longstanding black box warning from bioidentical Estradiol products including patches, gels, and topical creams. This evidence-based decision led more doctors to prescribe HRT and more women to start treatment. The supply chain, however, was not prepared for the increase in demand.
Pharmaceutical supply chain consolidation over the past two decades has left very little manufacturing redundancy. When demand outpaces supply, there are no quick fixes — it takes months or longer for manufacturers to scale up production.
For a deeper dive into why finding this medication is so difficult, read our article on why Lyllana is so hard to find in 2026.
The shortage has also affected pricing. Here's what you can expect:
If cost is a barrier, Amneal Pharmaceuticals offers a Patient Assistance Program for eligible patients. You can also find coupons and discount programs in our complete savings guide for Lyllana.
While no new Estradiol patches have launched recently, here are some options patients are using:
Here's what's working for patients right now:
For detailed strategies, see our guide on how to find Lyllana in stock near you.
The Lyllana shortage is one of the most frustrating medication access issues facing women in 2026. It's driven by systemic problems — too few manufacturers, raw material constraints, and a sudden surge in demand — that won't be resolved overnight. But you don't have to navigate it alone.
Stay informed, work closely with your doctor, and use tools like Medfinder to stay ahead of the supply issues. If you're a provider looking for clinical guidance, see our provider shortage briefing.
You focus on staying healthy. We'll handle the rest.
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