Comprehensive medication guide to {drug} including estimated pricing, availability information, side effects, and how to find it in stock at your local pharmacy.
Dotti is a brand-name estradiol transdermal patch manufactured by Amneal Pharmaceuticals. It delivers 17β-estradiol — the most potent naturally occurring estrogen — through the skin and into the bloodstream. Dotti is FDA-approved for the treatment of moderate to severe hot flashes and vaginal atrophy caused by menopause, as well as the prevention of postmenopausal osteoporosis. It is applied twice weekly to the lower abdomen or upper buttocks.
Dotti delivers estradiol transdermally, bypassing the liver's first-pass metabolism. Once absorbed through the skin, estradiol binds to estrogen receptors throughout the body, restoring hormone levels that decline during menopause. This helps reduce vasomotor symptoms like hot flashes and night sweats, alleviates vaginal dryness and atrophy, and supports bone density to help prevent osteoporosis. The transdermal delivery method is considered safer than oral estrogen because it avoids the increased clotting risk associated with liver metabolism.
Each box contains 8 patches for a 1-month supply. Patches are applied twice weekly (every 3–4 days).
Dotti currently has a findability score of 40 out of 100, meaning it is difficult to find at most pharmacies. Estradiol patches, including Dotti, are experiencing an active shortage in early 2026. Demand surged after the FDA removed the black box warning from bioidentical estradiol patches in November 2025, and manufacturers have been unable to scale production quickly enough. If your pharmacy is out of stock, Medfinder can help you locate it nearby.
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Dotti is commonly prescribed by OB/GYNs, endocrinologists, primary care physicians, and internal medicine doctors. Menopause specialists certified by the North American Menopause Society (NAMS) are also frequent prescribers. Additionally, telehealth menopause platforms such as Midi Health, Alloy, and Evernow can prescribe Dotti online after a virtual consultation.
No, Dotti is not a controlled substance. It is not scheduled by the DEA. Estradiol is a bioidentical hormone and does not have abuse potential. However, it does require a prescription from a licensed healthcare provider.
Serious but rare side effects include blood clots, stroke, heart attack, and increased risk of endometrial cancer if used without a progestogen in women with a uterus. Consult your doctor if you experience any concerning symptoms.
Dotti is an effective and well-regarded estradiol patch for managing menopause symptoms and preventing osteoporosis. While the current shortage makes it harder to find, its findability score of 40 means it is still available at some pharmacies — you may just need to check a few locations. If you're struggling, Medfinder can help you locate Dotti in stock near you. Consider asking your doctor about alternative patches like Climara or generic estradiol patches if Dotti remains unavailable. With coupon programs, the cost can be as low as $26 per month, making it an affordable option even without insurance.
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