Medications

Dexedrine XR

Dexedrine XR

Previously Found with Medfinder

Comprehensive medication guide to {drug} including estimated pricing, availability information, side effects, and how to find it in stock at your local pharmacy.

Estimated Insurance Pricing
$10–$50 copay; usually Tier 2 coverage, but prior authorization or step therapy may be required.
Estimated Cash Pricing
$20–$685 retail depending on dose and pharmacy; as low as $32–$60 with GoodRx or SingleCare discount cards.
Medfinder Findability Score
35
/100
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Post Author

Peter Daggett

Last Updated

February 17, 2026

Dexedrine XR 2026 Availability, Prices, and Tips to Find

What Is Dexedrine XR?

Dexedrine XR (dextroamphetamine sulfate extended-release) is an amphetamine stimulant medication approved for treating ADHD in patients 6 years and older. It's the extended-release version of Dexedrine, providing once-daily dosing through its Spansule capsule technology. The medication is manufactured by Catalent Pharma Solutions for Amneal Pharmaceuticals and is available in both brand and generic formulations.

How does Dexedrine XR work?

Dexedrine XR works by increasing levels of dopamine and norepinephrine in the brain through two mechanisms: promoting the release of these neurotransmitters from nerve terminals and blocking their reuptake back into the nerve cells. This enhanced neurotransmitter activity improves focus, attention, and impulse control in patients with ADHD. The extended-release formulation provides therapeutic effects for 8-12 hours with once-daily morning dosing.

What doses are available for Dexedrine XR?

  • 5mg extended-release capsules - Starting dose for most patients
  • 10mg extended-release capsules - Common maintenance dose
  • 15mg extended-release capsules - Higher strength for established patients

All doses come as extended-release capsules (Spansule formulation) that should not be crushed, chewed, or opened.

How hard is it to find Dexedrine XR in stock?

Dexedrine XR is currently experiencing significant availability challenges as part of the ongoing ADHD stimulant shortage that began in 2022. With a findability score of 35/100, expect frequent stock-outs and longer wait times at most pharmacies. The shortage is primarily due to DEA production quotas limiting manufacturing. Call multiple pharmacies or use Medfinder to locate available stock in your area.

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Who Can Prescribe Dexedrine XR?

Dexedrine XR can be prescribed by various healthcare providers, including:

  • Psychiatrists - Often first choice for complex ADHD cases
  • Primary care physicians - Can prescribe for straightforward ADHD diagnosis
  • Pediatricians - Specialize in treating children with ADHD
  • Neurologists - May prescribe for ADHD with neurological components
  • Nurse practitioners - Can prescribe in most states with proper training

Teleheath prescribing is available in many states, though some providers may require in-person visits for initial evaluation of controlled substances.

Is Dexedrine XR a controlled substance?

Yes, Dexedrine XR is a Schedule II (CII) controlled substance under DEA classification due to its high potential for abuse and dependence. This means:

  • Prescriptions cannot be refilled - a new prescription is required each time
  • Prescriptions must be written for a maximum of 30 days (90 days in some states)
  • Electronic prescribing is required in most states
  • Pharmacies have stricter storage and dispensing requirements
  • Regular monitoring by your healthcare provider is required

The FDA requires a boxed warning about the risk of abuse, dependence, and potential for sudden death with misuse.

Common Side Effects of Dexedrine XR

  • Appetite loss - Very common, may lead to weight loss
  • Insomnia - Difficulty falling asleep, especially if taken late
  • Restlessness - Feeling jittery or unable to sit still
  • Irritability - Mood changes, particularly as medication wears off
  • Headache - Mild to moderate headaches
  • Stomach upset - Nausea, stomach pain, or discomfort
  • Weight loss - Due to appetite suppression

Serious side effects can include cardiovascular problems, psychiatric symptoms, growth suppression in children, and seizures. Contact your doctor immediately if you experience chest pain, mood changes, or allergic reactions.

Alternative Medications to Dexedrine XR

  • Adderall XR - Mixed amphetamine salts, similar duration
  • Vyvanse - Prodrug stimulant with smoother effects
  • Concerta - Methylphenidate-based extended-release
  • Ritalin LA - Another methylphenidate option
  • Evekeo XR - Pure racemic amphetamine extended-release
  • Generic dextroamphetamine ER - Bioequivalent generic versions

Your doctor may recommend trying different stimulants if Dexedrine XR is not available or not effective for you.

Drug Interactions with Dexedrine XR

  • MAOIs - Dangerous interaction; wait 14 days between medications
  • Tricyclic antidepressants - May increase amphetamine effects
  • Blood pressure medications - Amphetamines may reduce their effectiveness
  • Insulin and diabetes medications - May affect blood sugar control
  • Antihistamines - May counteract stimulant effects
  • Antacids - May increase absorption and effects

Acidic foods and beverages (citrus juices, vitamin C) may decrease absorption. High-fat meals may delay the medication's onset. Always inform your doctor about all medications, supplements, and vitamins you're taking.

Final Thoughts on Dexedrine XR

Dexedrine XR remains an effective treatment option for ADHD, offering the convenience of once-daily dosing with its extended-release formulation. However, the ongoing stimulant shortage means finding it in stock requires patience and persistence. If you're having trouble locating Dexedrine XR, consider using Medfinder to search multiple pharmacies at once, or discuss alternative medications with your healthcare provider. Remember that as a Schedule II controlled substance, proper storage, handling, and regular medical monitoring are essential for safe and effective treatment.

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