Comprehensive medication guide to Dexedrine XR including estimated pricing, availability information, side effects, and how to find it in stock at your local pharmacy.
Estimated Insurance Pricing
$10–$50 copay; usually Tier 2 coverage, but prior authorization or step therapy may be required.
Estimated Cash Pricing
$20–$685 retail depending on dose and pharmacy; as low as $32–$60 with GoodRx or SingleCare discount cards.
Medfinder Findability Score
35/100
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Dexedrine XR (dextroamphetamine sulfate extended-release) is an amphetamine stimulant medication approved for treating ADHD in patients 6 years and older. It's the extended-release version of Dexedrine, providing once-daily dosing through its Spansule capsule technology. The medication is manufactured by Catalent Pharma Solutions for Amneal Pharmaceuticals and is available in both brand and generic formulations.
Dexedrine XR works by increasing levels of dopamine and norepinephrine in the brain through two mechanisms: promoting the release of these neurotransmitters from nerve terminals and blocking their reuptake back into the nerve cells. This enhanced neurotransmitter activity improves focus, attention, and impulse control in patients with ADHD. The extended-release formulation provides therapeutic effects for 8-12 hours with once-daily morning dosing.
![Why is Dexedrine XR so hard to find? [Explained for 2026]](/_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2Fvur4atr4%2Fproduction%2F7f9d752abe7cd7807f3c8c418fee5e782743af53-1024x1024.png%3Frect%3D0%2C256%2C1024%2C512%26w%3D400%26h%3D200%26auto%3Dformat&w=828&q=75)
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5mg extended-release capsules - Starting dose for most patients
10mg extended-release capsules - Common maintenance dose
15mg extended-release capsules - Higher strength for established patients
Dexedrine XR is currently experiencing significant availability challenges as part of the ongoing ADHD stimulant shortage that began in 2022. With a findability score of 35/100, expect frequent stock-outs and longer wait times at most pharmacies. The shortage is primarily due to DEA production quotas limiting manufacturing. Call multiple pharmacies or use Medfinder to locate available stock in your area.
Dexedrine XR can be prescribed by various healthcare providers, including:
Teleheath prescribing is available in many states, though some providers may require in-person visits for initial evaluation of controlled substances.
Yes, Dexedrine XR is a Schedule II (CII) controlled substance under DEA classification due to its high potential for abuse and dependence. This means:
The FDA requires a boxed warning about the risk of abuse, dependence, and potential for sudden death with misuse.
Serious side effects can include cardiovascular problems, psychiatric symptoms, growth suppression in children, and seizures. Contact your doctor immediately if you experience chest pain, mood changes, or allergic reactions.
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Adderall XR
- Mixed amphetamine salts, similar duration
Vyvanse
- Prodrug stimulant with smoother effects
Concerta
- Methylphenidate-based extended-release
Ritalin LA
- Another methylphenidate option
Evekeo XR
- Pure racemic amphetamine extended-release
Generic dextroamphetamine ER
- Bioequivalent generic versions
Prefer Dexedrine XR? We can find it.
MAOIs
moderate- Dangerous interaction; wait 14 days between medications
Tricyclic antidepressants
moderate- May increase amphetamine effects
Blood pressure medications
moderate- Amphetamines may reduce their effectiveness
Insulin and diabetes medications
moderate- May affect blood sugar control
Antihistamines
moderate- May counteract stimulant effects
Antacids
moderate- May increase absorption and effects
Dexedrine XR remains an effective treatment option for ADHD, offering the convenience of once-daily dosing with its extended-release formulation. However, the ongoing stimulant shortage means finding it in stock requires patience and persistence. If you're having trouble locating Dexedrine XR, consider using Medfinder to search multiple pharmacies at once, or discuss alternative medications with your healthcare provider. Remember that as a Schedule II controlled substance, proper storage, handling, and regular medical monitoring are essential for safe and effective treatment.
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Our medication guides are researched and written to help patients make informed decisions. All content is reviewed for accuracy and updated regularly. Learn more about our standards
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