Can't find Dexedrine XR? Learn about alternatives like Adderall XR, Vyvanse, and methylphenidate options that may be easier to find.
If you've been searching everywhere for Dexedrine XR without success, you're facing a frustrating reality of the 2026 ADHD medication shortage. With a findability score of just 35, this extended-release dextroamphetamine medication has become one of the hardest ADHD treatments to locate.
But here's the good news: you have alternatives. While no two ADHD medications work exactly the same for every person, there are several effective options that might be easier to find and could work just as well for your symptoms. The key is understanding what makes each alternative different and working with your healthcare provider to find the best substitute.
Before exploring alternatives, let's review what makes Dexedrine XR unique. Dexedrine XR (also called Dexedrine Spansule) contains dextroamphetamine sulfate in an extended-release formulation. It works by increasing levels of dopamine and norepinephrine in the brain through two mechanisms: promoting the release of these neurotransmitters and blocking their reuptake.
Dexedrine XR typically lasts 8-12 hours with a single morning dose, making it convenient for all-day ADHD symptom management. It's a Schedule II controlled substance that's FDA-approved for ADHD in patients 6 years and older.
Understanding how your current medication works helps your doctor choose the best alternative that will provide similar benefits with hopefully better availability.
What it is: Adderall XR contains a combination of amphetamine salts: 75% dextroamphetamine and 25% levoamphetamine. This makes it very similar to Dexedrine XR, since the majority of the active ingredient is the same.
How it's different: The addition of levoamphetamine may provide slightly different effects. Some patients find Adderall XR gives them more physical energy, while others notice no difference from pure dextroamphetamine. The duration is similar – typically 8-12 hours.
Availability advantages: While Adderall XR has also faced shortages, it's made by multiple manufacturers, which sometimes makes it easier to find than Dexedrine XR. Different generic versions may be available when the brand isn't.
Typical dosing: If you take 10mg of Dexedrine XR, your doctor might start you on 10mg of Adderall XR, though individual adjustments are often needed.
Cost considerations: Generally similar to Dexedrine XR, with generic versions potentially being less expensive.
What it is: Vyvanse contains lisdexamfetamine, which is a "prodrug" that gets converted to dextroamphetamine in your body. This means you're ultimately getting the same active ingredient as Dexedrine XR, but through a different delivery mechanism.
How it's different: Because Vyvanse must be converted to dextroamphetamine by enzymes in your body, it tends to have a smoother onset and more consistent duration – typically 10-14 hours. It also can't be crushed or snorted for abuse, which some insurance companies prefer.
Availability advantages: Generic versions of Vyvanse became available in 2025, which has improved availability compared to when only brand-name was available. Multiple manufacturers now produce generic lisdexamfetamine.
Typical dosing: Vyvanse dosing isn't directly equivalent to Dexedrine XR. If you take 10mg Dexedrine XR, you might start with 20-30mg Vyvanse, but your doctor will determine the right dose for you.
Cost considerations: Generic Vyvanse has made this option more affordable than it was historically, though it may still cost more than generic dextroamphetamine.
What it is: Evekeo XR contains amphetamine sulfate in a 50/50 mix of dextroamphetamine and levoamphetamine. It's less commonly prescribed, which sometimes makes it more available during shortages.
How it's different: The 50/50 ratio is different from both Dexedrine XR (100% dextro) and Adderall XR (75% dextro, 25% levo). Some patients find this ratio provides good focus with manageable side effects.
Availability advantages: Because it's less popular, Evekeo XR is often available when other amphetamine medications are out of stock. Fewer patients are competing for the same supply.
Typical dosing: Dosing conversions vary, but your doctor will likely start with a similar milligram amount and adjust based on your response.
If amphetamine-based alternatives aren't available or don't work well for you, methylphenidate medications work through a similar but distinct mechanism.
Concerta (Methylphenidate ER):
Ritalin LA (Methylphenidate Extended-Release):
Other methylphenidate options: Metadate CD, Methylin ER, and other formulations may be available when the more popular options aren't.
Switching ADHD medications isn't as simple as taking the same dose of a different drug. Here's what to expect:
Dose conversion: Your doctor will calculate an equivalent starting dose, but this is just an estimate. You may need adjustments over the first few weeks.
Monitoring period: Expect closer follow-up during the first month as you and your doctor assess how well the new medication works and what side effects you experience.
Gradual transition: Some doctors prefer to transition gradually, especially if you're switching between different drug classes (like from amphetamine to methylphenidate).
Backup plan: Discuss what to do if the alternative doesn't work as well. Sometimes it takes trying 2-3 alternatives to find one that works as well as your original medication.
Switching ADHD medications can be challenging, especially if you're doing it because of a shortage rather than by choice. Here are strategies to help:
Plan the timing: If possible, start a new medication when you have lower demands at work or school, in case you need time to adjust.
Track your symptoms: Keep a daily log of how you feel, your focus levels, and any side effects. This helps your doctor make informed adjustments.
Be patient with yourself: It can take 2-4 weeks to fully assess how well a new ADHD medication is working. Don't judge it based on the first few days.
Communicate with your doctor: Report both positive changes and concerning side effects promptly so your dose can be optimized.
If you've tried several alternatives without success, don't give up. Additional options include:
Non-stimulant medications: Strattera (atomoxetine), Qelbree (viloxazine), and others work differently but can be effective for ADHD.
Immediate-release bridge therapy: Using regular Dexedrine (immediate-release) twice daily while continuing to search for Dexedrine XR.
Compounding pharmacy options: Some specialized pharmacies can create custom extended-release formulations.
Clinical trials: Research studies sometimes provide access to medications or new formulations not yet widely available.
When switching medications due to a shortage, insurance coverage becomes crucial:
For detailed cost-saving strategies, check out our guide on saving money on ADHD medications.
While it's frustrating that Dexedrine XR is so hard to find, effective alternatives do exist. The key is working closely with your healthcare provider to find an option that provides similar symptom control with better availability.
Remember that ADHD treatment is highly individual – what works perfectly for one person might not be ideal for another. Be prepared for some trial and adjustment as you find your best alternative, and don't hesitate to advocate for your treatment needs.
If you do find an alternative that works well, continue using tools like Medfinder to monitor Dexedrine XR availability in case you want to switch back once the shortage resolves. Having multiple medication options that work for you provides valuable flexibility during shortage periods.
Most importantly, don't go without treatment while searching for the perfect alternative. Managing ADHD symptoms is crucial for your daily functioning, work performance, and overall quality of life. A good-enough alternative that you can actually get is better than the perfect medication that's never in stock.
You focus on staying healthy. We'll handle the rest.
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