Dextroamphetamine XR: A Complete Overview

Dextroamphetamine XR is an extended-release central nervous system (CNS) stimulant prescribed to treat attention deficit hyperactivity disorder (ADHD) and narcolepsy.

If you've been prescribed this medication — or you're considering it — here's everything you need to know in 2026, from what it does to how much it costs.

What Is Dextroamphetamine XR?

Dextroamphetamine XR is the generic name for what was originally sold as Dexedrine Spansule. It contains dextroamphetamine sulfate in an extended-release capsule that releases medication gradually over the course of the day.

Key facts:

• Drug class: CNS stimulant (amphetamine)
• Original brand name: Dexedrine Spansule (now discontinued; only generics are available)
• Generic manufacturers: Teva, Mallinckrodt, Alvogen
• DEA schedule: Schedule II (CII) — high potential for abuse and dependence
• FDA-approved for: ADHD (ages 6+) and narcolepsy

Unlike mixed amphetamine salts (Adderall), dextroamphetamine XR contains only the d-isomer of amphetamine. Some patients and doctors prefer it for its cleaner side effect profile. To understand how it works in your body, see our article on how dextroamphetamine XR works.

What Is It Used For?

ADHD (Attention Deficit Hyperactivity Disorder)

Dextroamphetamine XR is a first-line treatment for ADHD in children (aged 6 and older), adolescents, and adults. It helps improve focus, reduce impulsivity, and control hyperactive behavior. The extended-release formula means one morning dose can last through the school or workday.

Narcolepsy

For people with narcolepsy — a condition that causes sudden, uncontrollable episodes of sleepiness — dextroamphetamine XR helps promote wakefulness during the day.

Off-Label Uses

Some doctors prescribe dextroamphetamine for treatment-resistant depression, binge eating disorder, or excessive daytime sleepiness, though these are not FDA-approved uses.

How Is Dextroamphetamine XR Taken?

Dextroamphetamine XR comes as extended-release capsules in 5 mg, 10 mg, and 15 mg strengths.

• Typical starting dose: 5–10 mg once daily in the morning
• Dose range: 5 mg to 40 mg daily
• Titration: Your doctor will typically increase the dose by 5–10 mg per week until the right dose is found

How to take it:

• Take it once daily in the morning. Taking it in the afternoon or evening can cause insomnia.
• You can swallow the capsule whole or open it and sprinkle the beads on applesauce. Do not crush or chew the beads — they're designed to release medication slowly.
• Avoid acidic foods and drinks (orange juice, vitamin C supplements) within 1 hour of dosing, as they can reduce how much medication your body absorbs.

Who Should Not Take Dextroamphetamine XR?

Dextroamphetamine XR is not safe for everyone. You should not take it if you have:

• A known allergy to amphetamines
• Taken an MAO inhibitor (MAOI) in the last 14 days — this combination can cause a dangerous spike in blood pressure
• Advanced hardening of the arteries (arteriosclerosis)
• Symptomatic heart disease
• Moderate to severe high blood pressure
• Hyperthyroidism (overactive thyroid)
• Glaucoma
• A history of drug abuse
• An agitated state or severe anxiety

Be sure to tell your doctor about all your medical conditions and medications before starting treatment. For a detailed list of drug interactions, see our guide on dextroamphetamine XR drug interactions.

How Much Does Dextroamphetamine XR Cost?

Since the brand-name Dexedrine Spansule is discontinued, only generic versions are available. Prices vary widely:

• Without insurance: $50 to $250 for 30 capsules, depending on the strength and pharmacy
• With a discount card: As low as $32 for 30 capsules using GoodRx or SingleCare
• With insurance: Most commercial and Medicare Part D plans cover generic dextroamphetamine ER, though prior authorization or step therapy (trying methylphenidate first) may be required

For more ways to save, read our complete guide to coupons, discounts, and patient assistance programs for dextroamphetamine XR.

Current Availability

As of early 2026, dextroamphetamine XR is affected by an ongoing national shortage. Some strengths — especially 10 mg and 20 mg — are particularly difficult to find. If your pharmacy is out, use Medfinder to check which pharmacies near you have it in stock.

Final Thoughts

Dextroamphetamine XR is a well-established ADHD and narcolepsy medication with decades of clinical use. It's effective, available as an affordable generic, and taken just once daily. The main challenges in 2026 are the ongoing shortage and the regulations around Schedule II prescriptions.

If you're starting this medication, make sure to learn about potential side effects and how to find it in stock near you.