Can't find dextroamphetamine XR? Here are 4 alternative ADHD medications your doctor may prescribe, including Vyvanse, Adderall XR, and more.
You've done everything right. You have a valid prescription for dextroamphetamine XR, you've called multiple pharmacies, and you've even tried Medfinder to search for stock near you. But the medication just isn't available in your area right now.
If this sounds familiar, you're not alone. The ongoing stimulant shortage has left many patients without access to their prescribed ADHD medications. The good news? There are several effective alternatives that your doctor can prescribe instead.
This guide covers what dextroamphetamine XR is, how it works, and four alternatives worth discussing with your prescriber.
Dextroamphetamine XR (extended-release) is a once-daily stimulant medication used to treat ADHD and narcolepsy. It was originally marketed as Dexedrine Spansule and is now available only as a generic. The capsule contains beads that release medication gradually throughout the day, providing up to 8 to 10 hours of symptom control.
It's a Schedule II controlled substance, meaning it has a high potential for abuse and is subject to strict prescribing and manufacturing regulations. For a deeper dive, read what is dextroamphetamine XR.
Dextroamphetamine increases levels of two key brain chemicals: dopamine and norepinephrine. It does this by blocking their reuptake (pulling them back into nerve cells) and promoting their release into the spaces between neurons. The result is improved focus, attention, and impulse control.
The extended-release formulation uses a bead-based delivery system. Some beads dissolve immediately, while others are coated to dissolve later, providing a smooth, sustained effect without requiring a second dose. Learn more in our post on how dextroamphetamine XR works.
The following medications are commonly prescribed for ADHD and may be available when dextroamphetamine XR is not. Always talk to your doctor before switching medications — what works best depends on your symptoms, medical history, and individual response.
What it is: Vyvanse is a prodrug of dextroamphetamine, meaning your body converts it into the same active ingredient as dextroamphetamine XR. It's FDA-approved for ADHD (ages 6+) and binge eating disorder.
How it's different: Because it's a prodrug, Vyvanse must be metabolized before it becomes active. This creates a smoother onset and is thought to carry a somewhat lower abuse potential compared to traditional amphetamines. It typically lasts 10 to 14 hours.
Availability: Vyvanse went generic in 2023, which has improved availability and reduced cost. Generic lisdexamfetamine may be easier to find than dextroamphetamine XR during the current shortage.
Cost: Generic versions can cost $30 to $80 for a 30-day supply with a discount card.
What it is: Adderall XR contains a mix of four amphetamine salts (75% dextroamphetamine, 25% levoamphetamine). It's one of the most commonly prescribed ADHD medications in the U.S.
How it's different: The addition of levoamphetamine may provide slightly different effects on focus versus physical energy. Adderall XR uses a two-bead system, typically lasting 10 to 12 hours.
Availability: Adderall XR has also been affected by the stimulant shortage, but because it has many generic manufacturers, some strengths may be more available than dextroamphetamine XR at any given time.
Cost: Generic Adderall XR ranges from $30 to $80 for 30 capsules with a GoodRx or SingleCare coupon.
What it is: Mydayis is a triple-bead extended-release formulation of mixed amphetamine salts. It's FDA-approved for ADHD in patients 13 and older.
How it's different: The three-bead system provides up to 16 hours of coverage — longer than most other stimulants. This can be helpful for patients who need symptom control into the evening.
Availability: Mydayis is a brand-name medication with no generic available yet, so it tends to be more expensive. However, it's not as widely prescribed, so it may be easier to find in stock.
Cost: Brand-name Mydayis can cost $300 to $400 per month without insurance. A manufacturer savings card may help reduce copays.
What it is: These are extended-release formulations of methylphenidate, a different class of stimulant. Concerta uses an osmotic-release (OROS) system, while Ritalin LA uses a bead-based system.
How it's different: Methylphenidate works on the same neurotransmitters as amphetamines but through a slightly different mechanism. Some patients respond better to methylphenidate, while others prefer amphetamines. Your doctor can help determine which is right for you.
Availability: Methylphenidate-based medications have generally been less affected by the current shortage, making them a practical alternative when amphetamines are unavailable.
Cost: Generic Concerta or methylphenidate ER can cost $20 to $60 for 30 tablets with a discount card.
Before switching to a completely different medication, ask your doctor about immediate-release (IR) dextroamphetamine tablets (sold as Zenzedi or generic). While you'll need to take it two to three times per day instead of once, it's the same active ingredient. Some strengths of the IR formulation may be more available than the XR capsules.
If you're considering an alternative, here are a few things to bring up at your appointment:
Your prescriber can help weigh the pros and cons of each option based on your specific situation.
Not being able to fill your prescription is stressful, especially when it's a medication you depend on daily. But the shortage doesn't mean you're out of options. Vyvanse, Adderall XR, Mydayis, and methylphenidate ER are all viable alternatives that can provide effective ADHD symptom control.
Start by checking Medfinder for current availability of dextroamphetamine XR near you. If it's truly unavailable, work with your prescriber to find the right alternative. And keep checking back — supply levels change frequently, and your preferred medication may become available again soon.
For more on how to save on any of these medications, see our guide on saving money on dextroamphetamine XR.
You focus on staying healthy. We'll handle the rest.
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