Lisdexamfetamine Is Expensive — But You Have Options

If you've ever looked at the cash price for Lisdexamfetamine (the generic version of Vyvanse) and felt your jaw drop, you're not alone. Without insurance or a discount coupon, a 30-day supply can cost $200 to $360 or more depending on the strength and pharmacy. Brand-name Vyvanse is even pricier, running $300 to $400 per month.

The good news? There are real ways to bring that cost down — sometimes dramatically. This guide walks through every major savings option available in 2026, with specific dollar amounts so you know what to expect.

What Does Lisdexamfetamine Cost Without Insurance?

Here's what you'd typically pay at a retail pharmacy without any discounts:

• Generic Lisdexamfetamine (30-day supply): $200 to $360, depending on strength and pharmacy
• Brand Vyvanse (30-day supply): $300 to $400
• Most commonly prescribed strengths (40 mg, 50 mg, 60 mg, 70 mg) tend to cost more than lower strengths

These prices vary by pharmacy — sometimes by $100 or more for the exact same medication. That's why comparing prices and using the right tools is so important.

Coupons and Discount Cards

Prescription discount cards are the easiest way to save on generic Lisdexamfetamine. These are free to use, don't require insurance, and are accepted at most pharmacies nationwide.

GoodRx

Typical price with GoodRx coupon: $60 to $85/month

GoodRx is the most widely known prescription discount platform. As of early 2026, GoodRx shows generic Lisdexamfetamine prices as low as $60.85 for a 30-day supply — that's up to 83% off the retail price. Prices vary by pharmacy and strength, so always compare before filling.

SingleCare

Typical price with SingleCare: $65 to $90/month

SingleCare offers similar discounts and is accepted at over 35,000 pharmacies. Their card can sometimes beat GoodRx prices depending on the pharmacy and location.

Optum Perks

Typical price: $65 to $95/month

Optum Perks (formerly SearchRx) provides competitive pricing and is backed by UnitedHealth Group. Worth checking alongside GoodRx and SingleCare.

Other Discount Cards to Compare

Don't stop at the big three. These additional discount programs may offer better prices depending on your location and pharmacy:

• BuzzRx — often competitive on generics
• RxSaver — by RetailMeNot, compares multiple discount programs
• ScriptSave WellRx — widely accepted at chain and independent pharmacies
• America's Pharmacy — sometimes offers the lowest price on stimulant medications
• Inside Rx — backed by Express Scripts, good for branded and generic medications

Pro tip: Prices can differ by $20 to $50 between coupon providers at the same pharmacy. Spend two minutes comparing before you fill. Use Medfinder to find pharmacies with stock, then compare coupon prices at those locations.

Patient Assistance Programs (PAPs)

If you're uninsured or underinsured and have a low income, patient assistance programs can provide Lisdexamfetamine at no cost or very low cost.

Takeda Help at Hand

Cost: Free (for eligible patients)

Takeda, the manufacturer of brand Vyvanse, offers the Help at Hand Patient Assistance Program (helpathandpap.com). This program provides brand Vyvanse at no cost to patients who:

• Are U.S. residents
• Have no insurance or inadequate insurance coverage
• Meet income eligibility requirements (typically below 300-400% of the federal poverty level)

Your doctor's office will need to submit an application on your behalf. Approval typically takes 2 to 4 weeks.

NeedyMeds

NeedyMeds (needymeds.org) maintains a database of patient assistance programs, discount drug cards, and other resources. Search for "Lisdexamfetamine" or "Vyvanse" to see all current programs.

RxAssist

RxAssist (rxassist.org) is another comprehensive database of pharmaceutical assistance programs, maintained by volunteers and funded by grants. They list both manufacturer programs and independent charity assistance options.

Other Ways to Save on Lisdexamfetamine

Use Your Insurance Wisely

If you have insurance, a few things to keep in mind:

• Always fill the generic unless your plan specifically covers brand Vyvanse at a lower tier
• Check your formulary tier: Generic Lisdexamfetamine is typically Tier 2 or Tier 3, with copays of $20 to $75
• Prior authorization: If your plan requires PA, make sure your doctor submits it promptly — delays mean delays in filling
• Appeal denials: If your plan denies coverage, you have the right to appeal. Your doctor can provide a letter of medical necessity.

Ask About 90-Day Supplies

Note: Schedule II controlled substances typically require a new prescription each month in most states. However, some states allow up to 90-day prescriptions. If yours does, filling a 90-day supply through a mail-order pharmacy or at your retail pharmacy may offer a per-pill discount. Ask your pharmacist about this option.

Compare Pharmacy Prices

Prices for the same generic medication can vary dramatically between pharmacies — even those across the street from each other. As a general rule:

• Costco pharmacy often has competitive pricing (you don't need a membership to use their pharmacy)
• Independent pharmacies may offer better cash prices than chains
• Walmart occasionally carries certain generics at reduced prices

Consider the Chewable Tablet

The chewable tablet formulation of Lisdexamfetamine is sometimes priced differently than capsules. Check coupon prices for both formulations — you might find a meaningful difference.

Explore State and Local Assistance

Many states have pharmaceutical assistance programs for residents who can't afford their medications. Programs vary by state, but they often cover controlled substances that federal programs may not. Check with your state's department of health or social services.

Final Thoughts

Nobody should have to choose between their health and their budget. Lisdexamfetamine is an effective medication for ADHD and binge eating disorder, and with the right tools, most patients can significantly reduce their out-of-pocket cost.

Start by comparing prices on GoodRx, SingleCare, and Optum Perks. If you're uninsured, look into Takeda's Help at Hand program. And use Medfinder to find pharmacies that actually have the medication in stock — because the best price in the world doesn't help if the pharmacy is out.

For more information on the current shortage and availability, see our 2026 Lisdexamfetamine shortage update. And if you're exploring other medication options, check out alternatives to Lisdexamfetamine.