Comprehensive medication guide to Neffy including estimated pricing, availability information, side effects, and how to find it in stock at your local pharmacy.
Estimated Insurance Pricing
$0–$50 copay with commercial insurance; prior authorization may be required by some plans.
Estimated Cash Pricing
$685–$800 for a 2-pack without insurance; commercially insured patients may pay as little as $0 with the Neffy Co-Pay Savings Program.
Medfinder Findability Score
55/100
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Neffy is the first and only needle-free epinephrine nasal spray approved for the emergency treatment of Type I allergic reactions, including anaphylaxis, in adults and children aged 4 years and older weighing 33 lbs (15 kg) or greater. Made by ARS Pharmaceuticals, Neffy delivers epinephrine through a simple nasal spray, eliminating the need for an intramuscular injection. This makes it an important option for patients who have needle phobia or caregivers who may hesitate to administer an injection during an emergency.
Neffy was approved by the FDA in August 2024 and became commercially available in late 2024. It is prescribed for patients at risk of anaphylaxis from food allergies, insect stings, medications, latex, exercise, or unknown triggers.
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Neffy delivers epinephrine (adrenaline) directly through the nasal mucosa into the bloodstream. Epinephrine is a sympathomimetic catecholamine that acts on both alpha- and beta-adrenergic receptors throughout the body:
One spray is administered into one nostril at the first sign of a severe allergic reaction. If symptoms persist after 5 minutes, a second dose can be given using a new device in the same nostril. Patients should always carry two devices and seek emergency medical care after any use.
Neffy 1 mg/0.1 mL nasal spray — spray
For children weighing 15 to less than 30 kg (33 to less than 66 lbs). Available since May 2025.
Neffy 2 mg/0.1 mL nasal spray — spray
For adults and children weighing 30 kg (66 lbs) or more.
Neffy receives a findability score of 55 out of 100, reflecting intermittent availability challenges. As a relatively new product (FDA-approved August 2024), pharmacy stocking is still expanding. While Neffy is not in a formal shortage, many local pharmacies may not carry it yet due to limited initial distribution. Patients may need to check multiple pharmacies or use Medfinder to locate it in stock near them. Availability is expected to improve throughout 2026 as more pharmacies add it to their inventory.
Neffy can be prescribed by a range of healthcare providers, including:
Telehealth appointments are also available for obtaining a Neffy prescription in many cases.
No, Neffy is not a controlled substance. It is not scheduled by the DEA. Epinephrine is a naturally occurring hormone and does not carry the abuse or dependence risks associated with controlled medications. Neffy can be prescribed and dispensed without the additional restrictions that apply to scheduled drugs.
Because Neffy is delivered as a nasal spray, its side effects include both typical epinephrine effects and nasal-specific reactions:
Serious side effects are rare but may include chest pain, fast or irregular heartbeat, severe hypertension, pulmonary edema, and ventricular arrhythmias. Seek immediate medical attention if these occur.
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EpiPen (Epinephrine Auto-Injector)
The most widely known injectable option, available in 0.3 mg (adults/children over 66 lbs) and 0.15 mg (children 33–66 lbs). Generic versions from Teva and Viatris are available. Cash price is approximately $300–$700 for a 2-pack.
Auvi-Q (Epinephrine Auto-Injector)
A compact auto-injector with voice-guided instructions, available in 0.1 mg, 0.15 mg, and 0.3 mg doses. Cash price approximately $300 for a 2-pack with coupons; a $35 copay program is available for commercially insured patients.
Adrenaclick / Generic Epinephrine Auto-Injector
A lower-cost injectable alternative available in 0.15 mg and 0.3 mg doses.
Symjepi (Epinephrine Injection)
A pre-filled syringe for manual injection in a compact form factor, available in 0.15 mg and 0.3 mg doses.
Prefer Neffy? We can find it.
Beta-blockers
moderateMay reduce the effectiveness of epinephrine and cause severe hypertension
MAO inhibitors
moderateCan potentiate the cardiovascular effects of epinephrine
Tricyclic antidepressants
moderateMay potentiate cardiovascular effects
Cardiac glycosides/Digoxin
moderateIncreased risk of arrhythmias when combined
Diuretics
moderateMay potentiate arrhythmias due to hypokalemia
Ergot alkaloids
moderateMay enhance vasoconstriction
Other nasal sprays
moderateMay alter nasal mucosa absorption of Neffy for up to 2 weeks
COMT inhibitors
moderate(for Parkinson's disease) — May increase epinephrine effects
Neffy represents a significant advancement in anaphylaxis treatment as the first needle-free epinephrine option. For patients with needle phobia, young children, or caregivers worried about administering an injection during a crisis, Neffy offers a simpler alternative that can be life-saving. While its retail cash price of $685–$800 per 2-pack is significant, the manufacturer's savings program can reduce costs to as little as $0 for insured patients or $25 for uninsured patients.
As a newer medication, finding Neffy in stock at your local pharmacy may take some effort. Use Medfinder to quickly locate pharmacies that have Neffy available near you. If your pharmacy doesn't carry it yet, ask them to order it — stocking is expanding rapidly as demand grows.
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