What Is Neffy?

Neffy is the first needle-free Epinephrine nasal spray approved for the emergency treatment of life-threatening allergic reactions (anaphylaxis) in adults and children aged 4 years and older.

Here's what you need to know about Neffy in 2026 — from what it treats, to how it works, to what it costs.

Brand Name, Generic, and Manufacturer

• Brand name: Neffy
• Generic name: Epinephrine nasal spray
• Manufacturer: ARS Pharmaceuticals Operations, Inc.
• Drug class: Sympathomimetic catecholamine (alpha- and beta-adrenergic agonist)
• FDA approval: August 2024
• Controlled substance: No — Neffy is not a controlled substance

Neffy was the first Epinephrine product to offer a needle-free alternative to auto-injectors like EpiPen and Auvi-Q, making it a breakthrough for patients with needle phobia or those who find injections difficult.

What Is Neffy Used For?

Neffy is used for the emergency treatment of Type I allergic reactions, including anaphylaxis. Anaphylaxis is a severe, potentially life-threatening allergic reaction that can happen within minutes of exposure to a trigger. Common triggers include:

• Foods (peanuts, tree nuts, shellfish, milk, eggs, wheat, soy)
• Insect stings (bees, wasps, hornets, fire ants)
• Medications (antibiotics, NSAIDs, anesthetics)
• Latex
• Exercise-induced anaphylaxis

Signs of anaphylaxis include:

• Difficulty breathing or swelling of the throat
• Hives, rash, or skin flushing
• Rapid or weak pulse
• Nausea, vomiting, or diarrhea
• Dizziness or fainting
• A feeling of impending doom

If you or someone near you shows these signs, use Neffy immediately and call 911.

How Is Neffy Taken?

Neffy is administered as a nasal spray — no injection required. Here's how:

1. Remove Neffy from its packaging
2. Insert the nozzle into one nostril
3. Press the plunger firmly to deliver one spray
4. Do not sniff after administration
5. Call 911 immediately after use

Dosing

• Adults and children weighing 66 lbs (30 kg) or more: 2 mg/0.1 mL — one spray into one nostril
• Children weighing 33 to 65 lbs (15 to under 30 kg): 1 mg/0.1 mL — one spray into one nostril

Second Dose

If symptoms persist or worsen after the first dose, administer a second dose using a new device into the same nostril starting 5 minutes after the first dose. Always carry at least two Neffy devices.

Storage

Store Neffy at room temperature. Keep it in its sealed packaging until ready to use. Check the expiration date regularly and replace expired devices promptly.

Who Should Not Take Neffy?

There are no absolute contraindications to using Epinephrine in a life-threatening allergic emergency. This means you should always use Neffy during anaphylaxis, even if you have other health conditions.

However, certain patients should use Neffy with caution and discuss their situation with their doctor beforehand:

• Patients with heart disease, coronary artery disease, or cardiac arrhythmias
• Patients with high blood pressure (hypertension)
• Patients with hyperthyroidism (overactive thyroid)
• Patients with diabetes
• Patients with Parkinson's disease
• Patients with kidney problems
• Patients with low potassium levels
• Patients with structural nasal conditions (deviated septum, nasal polyps) — these may affect absorption

If you're pregnant or breastfeeding, talk to your doctor about Neffy. In an anaphylactic emergency, the benefits of treatment typically outweigh the risks.

For information on medications that may interact with Neffy, see our guide on Neffy drug interactions.

How Much Does Neffy Cost?

Neffy's cost depends on your insurance coverage and whether you use savings programs:

• Cash price (without insurance): Approximately $685 to $800 for a 2-pack
• With commercial insurance: Most plans cover Neffy, though some may require prior authorization. The Neffy Co-Pay Savings Program can reduce your copay to as little as $0 for up to 4 devices (2 packs).
• Uninsured patients: The manufacturer offers a program where eligible patients may pay as little as $25 per prescription.
• Patient Assistance Program: Patients with no commercial or government drug coverage may receive Neffy at no cost through ARS Pharmaceuticals' assistance program.

Contact 1-877-MY-NEFFY (877-696-3339) or visit neffy.com/savings-and-support for details. For a full guide, see our article on how to save money on Neffy.

Is There a Generic?

No. There is no generic version of Neffy currently available. However, generic Epinephrine auto-injectors (EpiPen generics) are available for approximately $150 to $350 and may be an option if cost is a barrier. See alternatives to Neffy for more.

How Does Neffy Compare to Other Epinephrine Devices?

Neffy's main advantage is that it's needle-free. This matters because:

• Studies show that many patients delay or avoid using auto-injectors due to needle fear
• Caregivers (parents, teachers, babysitters) may feel more comfortable administering a nasal spray
• No risk of accidental needle sticks
• Easier to use under stress

The trade-off is that Neffy currently costs more than generic Epinephrine auto-injectors and may not be available at every pharmacy yet. For help finding it, use Medfinder to check pharmacy availability near you.

To learn about how Neffy works at the biological level, read our article on how Neffy works.

Final Thoughts

Neffy represents a major advancement in anaphylaxis treatment. As the first needle-free Epinephrine option, it removes one of the biggest barriers to emergency allergy treatment — the needle. Whether you're managing your own severe allergies or caring for a child with anaphylaxis risk, Neffy offers a simpler, less intimidating way to be prepared.

Talk to your doctor about whether Neffy is right for you, and use Medfinder to find it at a pharmacy near you.