Comprehensive medication guide to Jasmiel 28 Day including estimated pricing, availability information, side effects, and how to find it in stock at your local pharmacy.
Estimated Insurance Pricing
$0 copay for most ACA-compliant insurance plans under the contraceptive coverage mandate; Tier 1–2 on most formularies. Medicare Part D may not cover contraceptives for non-medical indications.
Estimated Cash Pricing
$103–$148 retail for Jasmiel brand; as low as $32 with GoodRx or $6.20 for generic drospirenone/ethinyl estradiol with SingleCare coupon for a 28-day supply.
Medfinder Findability Score
82/100
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Jasmiel 28 Day is an AB-rated generic combination oral contraceptive manufactured by Afaxys Pharma, LLC. It is the generic equivalent of Yaz (brand name by Bayer) and contains drospirenone 3 mg and ethinyl estradiol 0.02 mg. Each 28-day blister pack contains 24 active light pink tablets and 4 green placebo tablets.
Jasmiel 28 Day is FDA-approved for three indications: (1) contraception to prevent pregnancy in females of reproductive potential; (2) treatment of premenstrual dysphoric disorder (PMDD) symptoms in women who choose an oral contraceptive for birth control; and (3) treatment of moderate acne in females aged 14 and older who want oral contraceptive coverage.
Jasmiel is a monophasic contraceptive, meaning all active tablets contain the same hormone dose throughout the cycle. It uses a 24/4 schedule (24 active days, 4 placebo days) — shorter than the traditional 21/7 schedule, which provides tighter hormonal control.
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Jasmiel 28 Day prevents pregnancy through three complementary mechanisms: suppressing ovulation (the primary mechanism, with >90% ovulation inhibition in clinical studies), thickening cervical mucus to block sperm from reaching an egg, and thinning the uterine lining to prevent implantation.
Drospirenone is a unique progestin derived from spironolactone with two special properties: anti-mineralocorticoid activity (reduces sodium and water retention, potentially reducing bloating) and antiandrogenic activity (blocks androgen receptors, contributing to acne improvement and PMDD symptom relief). Ethinyl estradiol is a low-dose synthetic estrogen (0.02 mg) that works synergistically with drospirenone.
The 24/4 dosing schedule maintains more continuous hormone exposure than a 21/7 schedule, which minimizes hormone-withdrawal effects during the placebo week. Studies directly comparing the two schedules showed complete ovulation inhibition in 100% of subjects on the 24/4 regimen during the first cycle.
3 mg / 0.02 mg — tablet (28-day pack)
24 active light pink tablets (drospirenone 3 mg / ethinyl estradiol 0.02 mg) + 4 green placebo tablets. One tablet daily.
Jasmiel 28 Day is not currently listed on the FDA drug shortage database. The medication is generally available through most major pharmacy chains and mail-order services. However, because Jasmiel is one of several competing generics for Yaz (including Loryna, Nikki, Gianvi, Lo-Zumandimine, and Vestura), individual pharmacies may stock one or two of these generics preferentially and may not always carry Jasmiel by name.
Patients who specifically need Jasmiel (rather than another Yaz generic) may occasionally encounter localized stock gaps at certain pharmacies. These are typically resolved within 1-3 business days through distributor ordering. Calling ahead to confirm stock — or using a pharmacy-finding service to check availability — is the most reliable approach.
Rather than calling pharmacies yourself, you can use medfinder — a paid service that calls pharmacies near you to check which ones have Jasmiel 28 Day (or an equivalent generic) in stock, then texts you the results.
Jasmiel 28 Day is not a controlled substance, so any licensed prescriber can prescribe it without DEA special authority. The prescriber must evaluate the patient for contraindications (smoking + age >35, VTE history, renal/hepatic impairment, uncontrolled hypertension, etc.) before initiating treatment.
Telehealth prescribing is widely available for Jasmiel 28 Day. Services including Nurx, Pandia Health, Twentyeight Health, and Planned Parenthood Direct can evaluate patients entirely online and prescribe this medication, often with home delivery. This makes access significantly easier for patients in rural areas or those with limited in-person provider access.
No. Jasmiel 28 Day (drospirenone / ethinyl estradiol) is not a controlled substance and has no DEA schedule. This means it has no special prescription restrictions — providers can call in refills by phone, e-prescribe without additional authorization, and write 90-day supplies without the limitations that apply to Schedule II-V medications.
While Jasmiel requires a valid prescription from a licensed healthcare provider, it can be prescribed by any licensed prescriber including OB/GYNs, primary care physicians, nurse practitioners, physician assistants, and via telehealth platforms. Telehealth services like Nurx, Pandia Health, and Twentyeight Health commonly prescribe and deliver this medication.
The most commonly reported side effects in Jasmiel clinical trials include:
Serious side effects (seek emergency care immediately):
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Loryna 28 Day
AB-rated Yaz generic (drospirenone 3 mg / EE 0.02 mg); identical active ingredients; often more widely stocked
Nikki 28 Day
AB-rated Yaz generic (drospirenone 3 mg / EE 0.02 mg); identical active ingredients and indications including PMDD and acne
Yasmin / Ocella / Syeda
Same progestin (drospirenone 3 mg) but higher estrogen (EE 0.03 mg); 21/7 schedule; approved for contraception only (not PMDD or acne)
Sprintec (norgestimate/EE)
Different progestin class; widely available and covered; FDA-approved for contraception and acne; generally lower VTE risk profile
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Ombitasvir/paritaprevir/ritonavir ± dasabuvir (Viekira Pak)
majorContraindicated — coadministration causes severe ALT elevations (>5-20x ULN). Discontinue Jasmiel before starting this HCV regimen.
Rifampin, rifabutin, rifapentine
majorCYP3A4 inducers — significantly reduce hormone levels, increasing pregnancy risk. Use backup contraception.
Carbamazepine, phenobarbital, phenytoin, oxcarbazepine
majorAnticonvulsants that induce CYP3A4 — reduce contraceptive hormone levels. Backup contraception required.
St. John's Wort
majorCYP3A4 inducer — reduces contraceptive effectiveness. Avoid or use backup contraception.
ACE inhibitors (lisinopril, enalapril, etc.)
moderateCombined with drospirenone's anti-mineralocorticoid activity may cause hyperkalemia. Monitor serum potassium in first cycle.
Potassium-sparing diuretics (amiloride, spironolactone, triamterene)
moderateAdditive potassium-raising effect. Monitor serum potassium in first treatment cycle.
Lamotrigine (Lamictal)
moderateEE in Jasmiel significantly decreases lamotrigine levels through glucuronidation induction. May reduce seizure control — dose adjustments may be needed.
Mavacamten (Camzyos)
majorCYP3A4 inducer — may reduce contraceptive effectiveness. Use non-hormonal contraception during and for 4 months after treatment.
Jasmiel 28 Day is a well-established, FDA-approved generic oral contraceptive that offers three indications: contraception, PMDD symptom management, and moderate acne treatment. Its unique progestin — drospirenone — provides anti-mineralocorticoid and antiandrogenic benefits that set it apart from many other oral contraceptive options.
Most patients with ACA-compliant insurance can get Jasmiel 28 Day for $0 copay, and uninsured patients can access it for as low as $6.20 per pack with a SingleCare coupon. Jasmiel is not currently on FDA shortage, and localized pharmacy stock gaps can typically be resolved by asking for an equivalent generic (Loryna, Nikki, Gianvi) or ordering through the pharmacy's distributor.
If you're having trouble finding Jasmiel 28 Day at a pharmacy near you, medfinder can call nearby pharmacies and text you which ones have your prescription in stock — no hold times, no driving around.
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