Comprehensive medication guide to Yasmin 28 including estimated pricing, availability information, side effects, and how to find it in stock at your local pharmacy.
Estimated Insurance Pricing
$0 copay for generic drospirenone/ethinyl estradiol under most ACA-compliant health plans (Tier 1); brand Yasmin 28 typically requires prior authorization and may carry a $30–$100+ copay at Tier 3–4, or may be excluded from formulary.
Estimated Cash Pricing
$96–$170 retail for brand Yasmin 28; as low as $8–$15 for generic drospirenone/ethinyl estradiol 3/0.03 mg with GoodRx or SingleCare coupons at major pharmacies for a 28-day supply.
Medfinder Findability Score
78/100
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Yasmin 28 is a brand-name combination oral contraceptive (birth control pill) manufactured by Bayer HealthCare Pharmaceuticals. Each 28-day blister pack contains 21 active yellow tablets and 7 inert white tablets. Each active tablet contains drospirenone 3 mg and ethinyl estradiol 0.03 mg — a progestin-estrogen combination that prevents ovulation and pregnancy.
Yasmin 28 is FDA-approved for the prevention of pregnancy and for the treatment of moderate acne in females 14 years of age and older who also choose to use oral contraception. It is a monophasic pill, meaning each active tablet delivers the same hormone dose throughout the cycle. Multiple FDA-approved generic equivalents are available, including Ocella, Syeda, Zarah, Nikki, Loryna, and Vestura.
Drospirenone is unique among progestins because it has antimineralocorticoid activity (similar to the diuretic spironolactone), which can reduce water retention and bloating. It also has mild antiandrogenic properties that can benefit patients with acne or hirsutism. However, it also slightly increases the risk of venous thromboembolism (VTE) compared to levonorgestrel-containing pills and can elevate potassium levels — important considerations for certain patients.
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Yasmin 28 prevents pregnancy through three complementary mechanisms. The primary mechanism is suppression of ovulation: the combination of drospirenone and ethinyl estradiol suppresses the FSH and LH signals from the pituitary gland that trigger ovarian egg release each month. Without these signals, no egg is released, and fertilization cannot occur.
The second mechanism is thickening of cervical mucus: drospirenone causes the mucus at the cervix to become thicker and more viscous, physically impeding sperm from swimming through the cervix to reach an egg. The third mechanism is endometrial changes: the combination thins the uterine lining, making it less receptive to a fertilized egg if ovulation were to occur.
Beyond contraception, drospirenone's antimineralocorticoid activity blocks aldosterone receptors in the kidneys, reducing sodium and water retention. This can decrease bloating and edema that some women experience on progestins without this property. Its antiandrogenic activity helps reduce sebum production, contributing to its acne-reducing effects.
3 mg / 0.03 mg — tablet (21 active + 7 inert)
Standard Yasmin 28 dose: 1 active yellow tablet daily for 21 days, then 1 inert white tablet daily for 7 days
Yasmin 28 and its generic equivalents are not on the FDA's drug shortage list as of 2026. Multiple generic manufacturers supply the market, making national-level supply stable. The findability score for Yasmin 28 is 78/100 — indicating it is generally available but may require checking multiple pharmacies due to brand-vs-generic stocking variations and insurance formulary dynamics.
Brand-name Yasmin 28 is less consistently stocked than its generics, as most insurance plans prefer generic drospirenone/ethinyl estradiol and pharmacies stock accordingly. Patients specifically requesting the brand may need to check multiple locations or ask their pharmacist to special-order it. Generics (Ocella, Syeda, Zarah) are widely stocked at CVS, Walgreens, Walmart, Costco, and independent pharmacies.
If your pharmacy is out of stock, medfinder can call pharmacies near you to find which ones have Yasmin 28 or its generic equivalent in stock — saving you the time and frustration of calling pharmacies yourself.
Yasmin 28 is not a controlled substance, so any licensed prescriber in the United States can write a prescription for it. There are no DEA schedule restrictions or special registration requirements. It can be prescribed after an appropriate clinical evaluation, including a health history review to assess for contraindications (history of blood clots, kidney/liver disease, smoking + age >35, migraines with aura).
Providers who commonly prescribe Yasmin 28 include:
OB/GYNs (Obstetrician-Gynecologists)
Primary care physicians (family medicine, internal medicine)
Nurse practitioners (NPs) — full independent prescribing in many states
Physician assistants (PAs)
Certified nurse-midwives (CNMs)
Planned Parenthood and Title X family planning clinic providers
Yasmin 28 is widely available via telehealth. Platforms such as Nurx, Pandia Health, Planned Parenthood Direct, and The Pill Club can prescribe and ship Yasmin 28 or its generic equivalent after an online consultation — often within 24 hours. Telehealth is available in all 50 states for hormonal contraceptive prescribing.
No. Yasmin 28 (drospirenone/ethinyl estradiol) is not a controlled substance and is not scheduled by the Drug Enforcement Administration (DEA). It does not have abuse potential and does not require any special DEA prescriber registration or triplicate prescription forms.
Any licensed healthcare provider — including nurse practitioners, physician assistants, and certified nurse-midwives — can prescribe Yasmin 28 without special authorization. It can be prescribed via telehealth in all 50 states and dispensed at any pharmacy. Refills can be given at any time, and prescriptions can be written for up to a 12-month supply in many states. There are no federal limits on prescription quantities or refill frequencies for non-controlled medications.
The following side effects are commonly reported and typically improve within the first 2–3 months of use:
Nausea (take with food or at bedtime to reduce)
Breakthrough bleeding or spotting between periods
Breast tenderness or pain
Headache or migraine
Mood changes, irritability, or low mood
Decreased libido (sex drive)
Vaginal discharge or yeast infections
Stop taking Yasmin 28 and call 911 or go to the emergency room if you experience:
Signs of blood clot (DVT): leg pain, swelling, redness, warmth
Pulmonary embolism: sudden shortness of breath, chest pain, coughing blood
Stroke: sudden numbness, weakness, facial drooping, vision loss, severe headache
Heart attack: chest pain, jaw/arm pain, sweating, nausea
Liver problems: jaundice (yellow skin/eyes), dark urine, upper right abdominal pain
Hyperkalemia: muscle weakness, irregular heartbeat, fatigue (especially if on potassium-raising medications)
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Yaz (drospirenone 3 mg / EE 0.02 mg)
Same drospirenone progestin with lower estrogen (0.02 mg) and 24/4 active/inert schedule. Also FDA-approved for PMDD and acne. May be preferred for estrogen-sensitive patients.
Sprintec (norgestimate/ethinyl estradiol)
Monophasic COC with norgestimate progestin. Lower VTE risk than drospirenone-containing pills. Widely stocked; generics available for as low as $4–$10/month.
Apri / Reclipsen (desogestrel/ethinyl estradiol)
Combination COC with desogestrel progestin. Good tolerability profile; FDA-approved generics widely available and inexpensive.
Lo Loestrin Fe (norethindrone acetate 1 mg / EE 10 mcg)
Ultra-low estrogen COC for patients sensitive to higher estrogen doses. Norethindrone progestin; no antimineralocorticoid activity.
Prefer Yasmin 28? We can find it.
Rifampin
majorPotent CYP3A4 inducer; can reduce contraceptive efficacy by up to 90%. Avoid combination — use non-hormonal contraception during rifampin courses.
Carbamazepine (Tegretol)
majorAnticonvulsant CYP3A4 inducer; reduces estrogen and drospirenone blood levels. Use backup contraception during co-administration.
St. John's Wort
majorHerbal CYP3A4 inducer; reduces hormone levels and may cause breakthrough bleeding and contraceptive failure. Avoid concurrent use.
Spironolactone / Potassium-sparing diuretics
majorAdditive potassium-retaining effect with drospirenone. Monitor potassium levels during first month of concurrent use.
ACE inhibitors (lisinopril, enalapril)
moderateIncreased risk of hyperkalemia when combined with drospirenone. Monitor potassium during first cycle.
ARBs (losartan, valsartan)
moderateAdditive potassium-raising effect with drospirenone's antimineralocorticoid activity. Monitor potassium.
Hepatitis C antivirals (ombitasvir/paritaprevir/ritonavir)
majorContraindicated — co-administration can cause significant ALT elevations. Discontinue Yasmin 28 before starting these HCV treatments.
Lamotrigine (Lamictal)
moderateCOCs including Yasmin 28 may reduce lamotrigine blood levels, potentially increasing seizure risk in epilepsy patients. Monitor levels and adjust dose as needed.
Yasmin 28 is a well-established, effective combination oral contraceptive that offers additional benefits over older pill formulations thanks to drospirenone's antimineralocorticoid and antiandrogenic properties. It's a popular choice for patients who experience bloating, water retention, or acne on older progestin-based pills. With over 99% effectiveness at preventing pregnancy with perfect use, it remains one of the most trusted birth control options available.
Cost is manageable: generic drospirenone/ethinyl estradiol 3/0.03 mg is covered at $0 copay under most ACA-compliant health plans, and can be obtained for as little as $8–$15 per month with discount cards for uninsured patients. Multiple FDA-approved generic manufacturers ensure stable supply and wide availability at pharmacies across the country.
If you're having trouble filling your Yasmin 28 prescription at your local pharmacy, medfinder can help. medfinder contacts pharmacies near you to find which ones have your medication in stock, then texts you the results — taking the hassle out of pharmacy hunting so you can stay consistent with your birth control.
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Our medication guides are researched and written to help patients make informed decisions. All content is reviewed for accuracy and updated regularly. Learn more about our standards
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