Comprehensive medication guide to Loryna 28 Day including estimated pricing, availability information, side effects, and how to find it in stock at your local pharmacy.
Estimated Insurance Pricing
$0 for most patients with qualifying private insurance under the ACA contraceptive mandate for generic oral contraceptives; Tier 1–2 on most formularies, quantity limits may apply.
Estimated Cash Pricing
$75–$100 retail per 28-day pack without a coupon; as low as $6.20 with a SingleCare coupon or $25–$32 with GoodRx for a one-month supply of generic drospirenone/ethinyl estradiol.
Medfinder Findability Score
55/100
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Loryna 28 Day is a combination oral contraceptive (birth control pill) containing drospirenone 3 mg and ethinyl estradiol 0.02 mg (20 mcg). It is a branded generic of the original Yaz formulation, manufactured by Laboratorios Leon Farma in Spain and distributed in the U.S. by Xiromed, LLC. Each 28-day blister pack contains 24 active peach tablets with both hormones and 4 white inert (placebo) tablets.
Loryna is FDA-approved for three indications: (1) contraception, (2) treatment of premenstrual dysphoric disorder (PMDD) in women who choose oral contraception, and (3) treatment of moderate acne vulgaris in women 14 years and older who also desire contraception. It is one of very few oral contraceptives with all three of these FDA-approved indications.
Loryna is bioequivalent to Yaz and several other branded generics including Nikki, Vestura, Jasmiel, Lo-Zumandimine, Syeda, and Gianvi — all containing drospirenone 3 mg and ethinyl estradiol 0.02 mg in the same 24/4 dosing schedule.
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Loryna prevents pregnancy through three mechanisms: suppression of ovulation (blocking the LH surge that triggers egg release), thickening of cervical mucus (creating a barrier to sperm), and thinning of the uterine lining (reducing likelihood of implantation). Ovulation suppression is the primary mechanism and accounts for the majority of its contraceptive efficacy.
Drospirenone is unique among progestins because it is a spironolactone analogue with anti-mineralocorticoid activity (blocks aldosterone, reducing fluid retention) and anti-androgenic activity (blocks androgen receptors, reducing sebum production and acne). These properties explain Loryna's efficacy for PMDD (through hormonal stabilization and shorter hormone-free interval) and for acne (through androgen receptor blockade).
The 24/4 dosing schedule — 24 active pills followed by only 4 placebo pills — creates a shorter hormone-free interval than the traditional 21/7 schedule. This shorter gap reduces hormone-withdrawal symptoms and is integral to Loryna's FDA approval for PMDD management.
3 mg / 0.02 mg — tablet
28-day pack: 24 active peach tablets (drospirenone 3 mg + ethinyl estradiol 0.02 mg) + 4 white inert placebo tablets. Take 1 tablet daily in order.
Loryna 28 Day is not on the FDA's official drug shortage list, but patients regularly experience localized stockouts at chain pharmacies. The primary reason is that pharmacies rotate between the 10+ branded generics of drospirenone/ethinyl estradiol 0.02mg based on wholesaler contracts — switching from Loryna to Nikki, Vestura, or Jasmiel without notice to patients. Multiple manufacturers also discontinued specific drospirenone/ethinyl estradiol NDC formulations in 2025, further disrupting regional supply chains.
When Loryna is out of stock, bioequivalent generics (Nikki, Vestura, Jasmiel) are usually available nearby. Use medfinder to call pharmacies near you and find which ones have Loryna or an equivalent in stock — without spending hours on hold yourself.
Independent pharmacies and warehouse club pharmacies (Costco, Sam's Club) typically have better access to multiple generics and are worth checking when chain pharmacies are out. Mail-order pharmacy through your insurance is another reliable option for 90-day supplies.
Loryna 28 Day is not a controlled substance, so it can be prescribed by any licensed healthcare provider with prescriptive authority. There are no DEA scheduling requirements or special restrictions on prescribing, making it widely accessible through multiple provider types.
OB-GYN (Obstetrician-Gynecologist)
Primary Care Physician (Internal Medicine, Family Medicine)
Nurse Practitioner (NP) — independent prescribing authority in most states
Physician Assistant (PA) — prescribing in all 50 states with physician oversight as applicable
Dermatologist (specifically for the acne indication)
Telehealth providers via services such as Nurx, Wisp, SimpleHealth, and RedBox Rx
Loryna is readily available via telehealth since it is not a controlled substance. Platforms like Nurx, Wisp, and SimpleHealth can prescribe drospirenone/ethinyl estradiol generics online after a health questionnaire and prescriber review — often with home delivery. Patients can also access prescriptions through Planned Parenthood and federally qualified health centers for low-cost or sliding-scale care.
No. Loryna 28 Day (drospirenone/ethinyl estradiol) is not a controlled substance and has no DEA scheduling. It is a non-scheduled prescription medication that can be prescribed by any licensed healthcare provider including OB-GYNs, primary care physicians, nurse practitioners, and physician assistants.
Because Loryna is not controlled, prescriptions can be sent electronically or called in to the pharmacy without the restrictions that apply to Schedule II-IV drugs. Refills can be issued without the patient requiring an in-person visit at every fill (though annual check-ups for blood pressure monitoring are recommended). Loryna can also be prescribed via telehealth without the limitations that apply to controlled substances.
Most side effects of Loryna are mild and tend to improve after 2-3 months as the body adjusts. Common side effects include:
Irregular menstrual bleeding or spotting (especially in first 1-3 months)
Nausea (reduced by taking with food or at bedtime)
Headache or migraine
Breast tenderness or pain
Mood changes or decreased libido
Weight changes (primarily water retention)
Contact lens discomfort
Dark skin patches (melasma) with sun exposure
Blood clots (DVT, pulmonary embolism, stroke, heart attack) — leg pain/swelling, chest pain, sudden shortness of breath, sudden severe headache, vision changes
High potassium (hyperkalemia) — muscle weakness, irregular heartbeat, numbness/tingling
Liver damage — jaundice (yellow skin/eyes), dark urine, upper right abdominal pain
Severely elevated blood pressure (systolic ≥180 or diastolic ≥120)
Severe allergic reaction — hives, difficulty breathing, facial swelling
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Nikki 28 Day
Branded generic of Yaz — identical active ingredients (DRSP 3mg/EE 0.02mg), 24/4 schedule. FDA AB-rated bioequivalent to Loryna.
Vestura 28 Day
Another branded generic with the same drospirenone 3mg/ethinyl estradiol 0.02mg formulation. Bioequivalent substitute for Loryna.
Jasmiel 28 Day
Bioequivalent generic of Yaz containing DRSP 3mg/EE 0.02mg. Can substitute for Loryna in most cases.
Yaz
Brand-name version of the same formulation (DRSP 3mg/EE 0.02mg). Higher cost than Loryna without insurance; same clinical effects.
Yasmin / Ocella
Same progestin (drospirenone 3mg) with higher estrogen dose (0.03mg EE) and 21/7 schedule. Requires new prescription; not bioequivalent.
Prefer Loryna 28 Day? We can find it.
Rifampin / Rifabutin
majorPotent CYP3A4 enzyme inducers that can significantly reduce drospirenone and ethinyl estradiol levels, compromising contraceptive effectiveness. Use non-hormonal backup contraception.
Carbamazepine (Tegretol)
majorAntiepileptic enzyme inducer that reduces hormonal levels. May significantly decrease Loryna's contraceptive efficacy. Consider alternative contraception.
St. John's Wort
majorHerbal supplement that is a potent CYP3A4 inducer. Can significantly reduce ethinyl estradiol and drospirenone levels. Avoid use with Loryna.
Ombitasvir/paritaprevir/ritonavir (Viekira Pak)
majorHepatitis C combination antiviral. CONTRAINDICATED with Loryna — can cause significant liver enzyme elevations (ALT). Stop Loryna if initiating this regimen.
ACE Inhibitors (lisinopril, enalapril)
moderateCan raise potassium levels; combined with drospirenone's anti-mineralocorticoid effect, may cause hyperkalemia. Monitor potassium at first cycle.
Potassium-sparing diuretics (spironolactone, eplerenone)
moderateCan cause dangerous hyperkalemia when combined with drospirenone's potassium-raising effect. Potassium monitoring required.
Lamotrigine (Lamictal)
moderateCOCs can reduce lamotrigine levels by approximately 50%, potentially causing breakthrough seizures. Dose adjustment and monitoring required.
Topiramate (Topamax)
moderateReduces ethinyl estradiol levels; may compromise contraceptive effectiveness. Consider additional contraceptive methods.
NSAIDs (ibuprofen, naproxen) — long-term use
minorLong-term daily NSAID use may raise potassium; combined with drospirenone may increase hyperkalemia risk. Occasional use is generally safe.
Loryna 28 Day is a well-established, low-dose oral contraceptive with a unique combination of benefits: FDA approval for contraception, PMDD, and acne, paired with drospirenone's anti-mineralocorticoid and anti-androgenic properties. For the millions of women who rely on it, ensuring consistent access is a real concern given the fragmented generic market and localized stock variability.
The most important things to know: ask your pharmacy about bioequivalent generics (Nikki, Vestura, Jasmiel) when Loryna is unavailable; most patients with insurance pay $0 under the ACA contraceptive mandate; and without insurance, discount cards like SingleCare can bring the price to as low as $6.20 per pack.
If you're struggling to find Loryna at a pharmacy near you, medfinder calls pharmacies in your area to identify which ones have it in stock — saving you hours of calls and helping you stay on schedule with your medication.
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Our medication guides are researched and written to help patients make informed decisions. All content is reviewed for accuracy and updated regularly. Learn more about our standards
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