Dotti estradiol patches are hard to find in 2026 due to a nationwide shortage. Learn why the shortage is happening and what you can do to get your prescription filled.
If you've called pharmacy after pharmacy looking for Dotti — the estradiol transdermal patch used to treat menopause symptoms — you already know something is wrong. In early 2026, Dotti is genuinely hard to find. Pharmacies are running out. Backorders are piling up. And patients across the country are scrambling to fill prescriptions they depend on.
You're not imagining it. There is an active nationwide shortage of estradiol patches, and Dotti is one of the hardest-hit products. In this post, we'll explain exactly what's going on, why it's happening, and — most importantly — what you can do about it.
Dotti is a brand-name estradiol transdermal patch made by Amneal Pharmaceuticals. It delivers a steady dose of estradiol (a form of estrogen) through your skin over 3 to 4 days. You apply a new patch twice a week.
Doctors prescribe Dotti for:
Dotti comes in five strengths: 0.025 mg/day, 0.0375 mg/day, 0.05 mg/day, 0.075 mg/day, and 0.1 mg/day. It's essentially the same medication as Vivelle-Dot, reformulated with a smaller patch size. For more details, see our full guide: What Is Dotti? Uses, Dosage, and What You Need to Know.
The Dotti shortage isn't caused by a single issue. It's the result of several factors hitting at once:
In November 2025, the FDA took a historic step: it removed the black box warning from bioidentical estradiol patches, gels, and creams. For over 20 years, that warning scared both patients and doctors away from hormone replacement therapy (HRT), even when the benefits outweighed the risks for many women.
With the warning gone, millions of women who had been avoiding HRT started conversations with their doctors. Prescriptions surged almost overnight — and manufacturers weren't ready.
Even before the FDA's announcement, demand for estradiol patches had been climbing since around 2020. Telehealth menopause companies like Midi Health, Alloy, and Evernow made it easier than ever to get prescribed HRT. The black box removal was the tipping point that sent demand through the roof.
Estradiol patch manufacturing is specialized. You can't just flip a switch and double output. Scaling up production takes months to years, and the supply chain simply hasn't caught up.
Only a handful of companies make estradiol transdermal patches. Amneal Pharmaceuticals makes Dotti, but the total number of manufacturers producing any estradiol patch is small. When demand spikes, there aren't many alternatives to absorb the overflow.
Even when patches are manufactured, they don't always end up where patients need them. Large chain pharmacies may receive priority allocations, while smaller pharmacies get shorted. Some regions of the country are hit harder than others, creating a patchwork of availability.
The good news: you have options. Here's what we recommend:
At Medfinder, we track which pharmacies actually have Dotti and other estradiol patches in stock. Instead of calling 10 pharmacies yourself, you can search once and see where to go. It's free and updated regularly.
Big chains like CVS and Walgreens often run out first because they serve the most patients. Independent and compounding pharmacies may have stock that chain pharmacies don't. They can also sometimes order from different wholesalers.
If you can't find Dotti specifically, other estradiol patches may be available. Climara (a once-weekly patch), generic estradiol patches, or even estradiol gel (EstroGel, Divigel) deliver the same active ingredient through a different format. Your doctor can help you switch without interrupting your therapy.
If you're running low, start looking for your refill early — at least 7 to 10 days before you need it. This gives you time to search multiple pharmacies or use tools like Medfinder to locate stock.
Pharmacists can often check their distributor's inventory and tell you when the next shipment is expected. They may also be able to transfer your prescription to a pharmacy that has it in stock.
Unfortunately, there's no firm end date. The FDA is monitoring the supply situation, and manufacturers like Amneal are working to increase production. However, industry experts suggest the shortage could continue through much of 2026 as supply catches up to the new, higher level of demand.
For the latest updates, check our Dotti shortage update for 2026.
If you're struggling to find Dotti, know that this isn't your fault and you're not alone. A perfect storm of increased demand, limited manufacturers, and a historic FDA decision created a shortage that has left patients across the country frustrated.
But you don't have to navigate it alone. Medfinder can help you find Dotti and other estradiol patches in stock near you. And if Dotti isn't available, your doctor can work with you to find an alternative that keeps your treatment on track.
Your health matters. Don't let a shortage derail your care.
You focus on staying healthy. We'll handle the rest.
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