Dotti Can Be Expensive — But You Don't Have to Pay Full Price

If you've been prescribed Dotti estradiol patches for menopause symptoms, you may have experienced sticker shock at the pharmacy counter. Without insurance, a one-month supply of Dotti (8 patches) can cost $105 to $191 depending on the dose and pharmacy.

The good news: there are several ways to pay significantly less. In this guide, we'll walk through every major savings option — from free coupon cards to patient assistance programs that provide Dotti at no cost for qualifying patients.

How Much Does Dotti Cost Without Insurance?

Here's what you can expect to pay at retail (cash price, no insurance or coupons):

• Dotti 0.025 mg/day (8 patches): ~$105–$130
• Dotti 0.0375 mg/day (8 patches): ~$110–$140
• Dotti 0.05 mg/day (8 patches): ~$105–$191
• Dotti 0.075 mg/day (8 patches): ~$120–$180
• Dotti 0.1 mg/day (8 patches): ~$130–$191

These prices vary by pharmacy and region. The ongoing shortage hasn't driven prices up significantly, but limited availability means you may not always be able to shop around for the best deal.

Coupon and Discount Cards

Prescription coupon cards are free to use and can cut your Dotti cost by 50% to 80%. Here are the best options:

GoodRx

GoodRx consistently offers some of the lowest prices for Dotti. As of early 2026:

• Dotti 0.05 mg/day (8 patches): As low as $25.83 (75% off retail)
• Free to use — just show the coupon at the pharmacy
• Available at most major pharmacies including CVS, Walgreens, and Walmart
• Visit: goodrx.com/dotti

SingleCare

SingleCare is another excellent option:

• Dotti 0.05 mg/day (8 patches): Starting around $45.21
• Free prescription discount card
• Accepted at over 35,000 pharmacies
• Visit: singlecare.com/prescription/dotti

Other Coupon Cards Worth Checking

Prices vary by pharmacy and region, so it's worth comparing across multiple services:

• RxSaver: rxsaver.com/drugs/dotti/coupons
• Optum Perks: perks.optum.com/drug/dotti
• BuzzRx: buzzrx.com/dotti/coupon
• America's Pharmacy: americaspharmacy.com/drug/dotti

Pro tip: Coupon card prices can change weekly. Check 2–3 services before you fill your prescription to find the current best price.

Patient Assistance Programs

If you're uninsured or underinsured and struggling to afford Dotti, patient assistance programs (PAPs) may provide your medication at little or no cost.

Amneal Patient Assistance Program

Amneal Pharmaceuticals, the maker of Dotti, offers a Patient Assistance Program for eligible patients:

• Provides free medication to qualifying individuals
• Available since 2012
• Eligibility typically based on income and insurance status
• Apply through your healthcare provider or visit amneal.com

Amneal PATHways Co-Pay Savings Program

If you have commercial insurance but still face high copays:

• The PATHways program can reduce your out-of-pocket cost
• Available for commercially insured patients (not government insurance)
• Visit amnealbiosciences.com/patient-support

Other Assistance Resources

• NeedyMeds: Database of patient assistance programs — needymeds.org
• RxAssist: Comprehensive database of pharmaceutical assistance programs — rxassist.org
• RxHope: Helps connect patients with manufacturer assistance — rxhope.com

Other Ways to Save on Dotti

Ask for Generic Estradiol Patches

Dotti is a branded generic, but plain generic estradiol transdermal patches may be even cheaper. With a GoodRx coupon, generic estradiol patches can cost as low as $25 to $50 for a month's supply. Ask your pharmacist if a generic is available and less expensive.

Consider Alternative Formulations

If cost is your primary concern, these alternatives may save you money:

• Oral estradiol tablets: As low as $4 to $15 per month. The cheapest estradiol option by far. Available at Walmart $4 prescription program and most pharmacies.
• Climara patches: Once-weekly, $27 to $84 with coupon. Fewer patches per month may mean lower cost.

For a full comparison, see Alternatives to Dotti.

Use Insurance Wisely

If you have insurance:

• Most commercial plans cover estradiol patches with copays of $10 to $30
• Check if your plan has a preferred estradiol product — using the preferred product means a lower copay
• Some plans require prior authorization or step therapy (trying oral estradiol first). Your doctor can help with the paperwork
• Medicare Part D generally covers estradiol patches

Mail-Order Pharmacies

Mail-order pharmacies often offer 90-day supplies at a discount. Check with your insurance plan to see if mail-order is covered. Amazon Pharmacy, Costco Pharmacy, and your insurance's preferred mail-order service are all worth comparing.

Costco Pharmacy (No Membership Required)

You do not need a Costco membership to use their pharmacy. Costco often has competitive cash prices — one patient reported paying $75 for a one-month supply of Dotti at Costco without insurance.

Final Thoughts

Dotti doesn't have to break the bank. Between coupon cards (which can bring a $191 prescription down to $26), patient assistance programs (which can make it free), and cheaper alternatives like oral estradiol ($4–$15/month), there's almost always a way to make your hormone therapy affordable.

Start with GoodRx or SingleCare for instant savings, and explore Amneal's patient assistance program if you need more help. And if you're struggling to find Dotti in stock, use Medfinder to locate pharmacies that have it — because the best price doesn't help if the pharmacy shelf is empty.

For more information, read How to Find Dotti in Stock Near You and What Is Dotti?.