Comprehensive medication guide to {drug} including estimated pricing, availability information, side effects, and how to find it in stock at your local pharmacy.
Depo-Medrol (Methylprednisolone Acetate) is an injectable corticosteroid manufactured by Pfizer. It is used to treat a wide range of inflammatory and autoimmune conditions, including rheumatoid arthritis, osteoarthritis, bursitis, severe allergic reactions, dermatologic diseases, and many other conditions where potent anti-inflammatory therapy is needed.
Depo-Medrol is administered by a healthcare provider via intramuscular, intra-articular, soft tissue, or intralesional injection. It is not taken at home — it must be given in a clinical setting. It is also used off-label for trigger point injections, epidural steroid injections, carpal tunnel syndrome, plantar fasciitis, and frozen shoulder.
Methylprednisolone Acetate is a synthetic glucocorticoid that works by suppressing the body's inflammatory and immune responses. It binds to intracellular glucocorticoid receptors and modulates gene transcription to decrease the production of prostaglandins, leukotrienes, and cytokines — key chemicals that drive inflammation, swelling, and pain.
By inhibiting the release of inflammatory mediators and reducing capillary permeability, Depo-Medrol provides potent, long-lasting relief from inflammation at the injection site.
Typical doses range from 4 mg to 120 mg depending on the condition being treated. Intra-articular doses are usually 20–80 mg, while intramuscular doses range from 40–120 mg.
Depo-Medrol has a findability score of 65 out of 100, meaning it can be moderately difficult to locate in stock. Methylprednisolone acetate injection has experienced intermittent shortages since 2012, with ongoing manufacturing delays at Pfizer and Sandoz affecting supply through 2024–2025. Some pharmacies and clinics may have limited stock of certain strengths (20 mg/mL, 40 mg/mL, or 80 mg/mL). Using Medfinder can help you quickly locate which providers near you currently have Depo-Medrol available.
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Depo-Medrol is prescribed and administered by a variety of healthcare specialists, including:
No. Depo-Medrol (Methylprednisolone Acetate) is not a controlled substance and has no DEA scheduling. It does not carry a risk of abuse or dependence. However, it is a prescription medication that must be administered by a licensed healthcare provider.
Serious side effects can include anaphylaxis, adrenal suppression, immunosuppression, osteoporosis with long-term use, avascular necrosis of bone, cataracts, glaucoma, peptic ulcers, and severe mood disturbances. Contact your healthcare provider immediately if you experience any serious symptoms.
If Depo-Medrol is unavailable or not suitable, your doctor may consider these alternatives:
Depo-Medrol can interact with several other medications:
Always inform your healthcare provider about all medications you are taking before receiving a Depo-Medrol injection.
Depo-Medrol is an effective and widely used injectable corticosteroid for treating inflammation, arthritis, and a variety of autoimmune conditions. While it has experienced intermittent supply shortages since 2012 — most recently due to manufacturing delays at Pfizer and Sandoz — it remains an important treatment option for many patients.
If you're having trouble finding Depo-Medrol in stock, use Medfinder to locate pharmacies and clinics near you that currently have it available. Generic Methylprednisolone Acetate may also be available at a lower cost, with discount card prices starting as low as $6 per vial.
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