The Depo-Medrol Shortage: Where Things Stand in 2026

If you depend on Depo-Medrol injections to manage arthritis, joint pain, or another inflammatory condition, the ongoing shortage has probably caused you real stress. Appointments get postponed. Pharmacies shrug. And you're left wondering when things will get back to normal.

Here's what we know about the Depo-Medrol (Methylprednisolone Acetate) shortage heading into 2026 — and what you can do about it.

Is Depo-Medrol Still in Shortage?

Yes. As of early 2026, Methylprednisolone Acetate injection continues to experience supply constraints. The shortage has been ongoing since 2024, when both Pfizer (the brand-name manufacturer of Depo-Medrol) and Sandoz (a major generic supplier) reported manufacturing delays.

The American Society of Health-System Pharmacists (ASHP) and the FDA have both tracked this shortage. While some strengths and vial sizes have become more available over time, supply remains inconsistent across the country. Some pharmacies and clinics have adequate stock, while others are still waiting for shipments.

The affected products include:

• Pfizer's Depo-Medrol in 40 mg/mL and 80 mg/mL vials
• Sandoz generic Methylprednisolone Acetate in 40 mg/mL and 80 mg/mL vials
• Various single-dose and multi-dose vial configurations

Why Is Depo-Medrol Hard to Find?

The shortage comes down to a few key factors:

Manufacturing Delays

Producing sterile injectable medications is complex. Both Pfizer and Sandoz experienced production issues that slowed output. When you're one of only a few companies making a product, any disruption ripples through the entire supply chain.

Increased Demand

Demand for injectable corticosteroids has been rising as more patients seek treatment for chronic joint conditions, sports injuries, and inflammatory diseases. An aging population means more people with arthritis and related conditions who rely on these injections.

Limited Manufacturers

Only a handful of companies produce Methylprednisolone Acetate injection in the United States. This limited competition means there's very little slack in the system when any one manufacturer has problems.

For a deeper dive into why this medication is hard to find, read: Why Is Depo-Medrol So Hard to Find? [Explained for 2026].

How Much Does Depo-Medrol Cost in 2026?

The cost of Depo-Medrol varies depending on the strength, vial size, pharmacy, and whether you have insurance.

Here's a general breakdown:

• Brand-name Depo-Medrol: $24 to $75 per vial at retail price, depending on strength
• Generic Methylprednisolone Acetate: As low as $6 to $25 per vial with a discount card from GoodRx or SingleCare
• With insurance: Many patients pay little to nothing because the injection is often billed as a medical benefit when administered in a doctor's office

During a shortage, prices can fluctuate. Some pharmacies may charge more when supply is tight, so it's worth shopping around. Check our full cost guide: How to Save Money on Depo-Medrol in 2026.

Are There New Options or Alternatives?

While no new Methylprednisolone Acetate products have entered the market recently, the existing alternatives remain solid options when Depo-Medrol isn't available:

• Kenalog (Triamcinolone Acetonide) — The most commonly used alternative for joint and soft tissue injections
• Celestone Soluspan (Betamethasone) — Provides both rapid and long-lasting relief
• Aristospan (Triamcinolone Hexacetonide) — Preferred by some rheumatologists for inflammatory joint conditions

Your doctor can help determine which alternative is best for your specific situation. Read more: Alternatives to Depo-Medrol If You Can't Fill Your Prescription.

How to Find Depo-Medrol in Stock

Despite the shortage, Depo-Medrol is available at many locations — you just might need to look a little harder. Here's how:

1. Check Medfinder

Use Medfinder to search for Depo-Medrol availability at pharmacies and clinics near you. It's the fastest way to see who has it in stock right now.

2. Call Independent Pharmacies

Independent pharmacies often have different supply chains than big chains and may have stock when CVS or Walgreens doesn't.

3. Ask Your Doctor's Office

Many providers stock Depo-Medrol directly and order through medical suppliers. Your doctor's office may have it even when retail pharmacies don't.

4. Check Specialty Clinics

Rheumatology, orthopedic, sports medicine, and pain management clinics frequently stock injectable corticosteroids. If your primary care doctor can't source Depo-Medrol, a specialist might be able to help.

For more detailed tips, read: How to Find Depo-Medrol in Stock Near You (Tools + Tips).

Final Thoughts

The Depo-Medrol shortage has been a challenge for patients and providers alike, but supply is gradually improving. In the meantime, stay proactive: check Medfinder regularly, explore independent pharmacies, and talk to your doctor about alternatives if needed.

This shortage won't last forever. The key is staying informed and knowing your options so you don't miss the treatment you need.