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Cepacol Antibacterial Mouthwash is an over-the-counter (OTC) oral antiseptic rinse containing Cetylpyridinium Chloride (CPC) 0.05% as its active ingredient. It belongs to the quaternary ammonium antiseptic class and is manufactured by RB Health (Reckitt Benckiser). Cepacol is the #1 mouthwash brand used in hospitals and is designed to:
It is approved for adults and children 12 years and older and is used as a complement to regular brushing and flossing.
The active ingredient, Cetylpyridinium Chloride (CPC), is a positively charged (monocationic) quaternary ammonium compound. It works by binding to the negatively charged surfaces of bacterial cell membranes in the mouth. This binding disrupts the membrane's integrity, increasing its permeability and causing leakage of intracellular contents — effectively killing the bacteria. This bactericidal action targets germs responsible for plaque buildup, gingivitis, and bad breath. CPC provides a residual antibacterial effect that continues working after you spit out the rinse.
The 32 oz size has been discontinued. The recommended dose is 20 mL swished vigorously for 30 seconds, twice daily.
Cepacol Antibacterial Mouthwash has a findability score of 55 out of 100, reflecting intermittent availability challenges. The 32 oz bottle has been discontinued by the manufacturer, and the remaining 24 oz size can be periodically out of stock at major retailers. While not listed on the FDA drug shortage list (as an OTC monograph product), reduced shelf space allocation and supply chain disruptions have made it harder to find consistently since 2024. Store-brand cetylpyridinium chloride (CPC) mouthwashes from retailers like Walmart (Equate) and Target (Up&Up) are more reliably available alternatives.
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Cepacol Antibacterial Mouthwash is an over-the-counter product and does not require a prescription. However, the following healthcare professionals commonly recommend it:
No, Cepacol Antibacterial Mouthwash is not a controlled substance. It is an over-the-counter (OTC) oral care product available without a prescription. It has no DEA schedule classification. Note that the product does contain 14% alcohol (v/v), which patients avoiding alcohol for medical, religious, or recovery reasons should be aware of.
These side effects are generally mild and temporary. Stop use and see a dentist if gingivitis, bleeding, or redness persists for more than 2 weeks, or if you experience signs of an allergic reaction such as swelling, rash, or difficulty breathing.
Cepacol Antibacterial Mouthwash generally has no significant interactions with systemic medications. Patients with tartrazine (FD&C Yellow #5) sensitivity or aspirin allergy should use caution, as this product contains tartrazine.
Cepacol Antibacterial Mouthwash is a trusted OTC oral antiseptic backed by decades of hospital use. While the product remains effective for plaque prevention, gingivitis reduction, and fighting bad breath, finding the Cepacol brand specifically has become more challenging. The 32 oz size has been discontinued, and the 24 oz bottle experiences intermittent stock-outs at major retailers.
If you're having trouble finding Cepacol, consider checking online retailers like Amazon or Walmart.com, or try a store-brand CPC mouthwash — they contain the same active ingredient at a lower price point. For patients who need a stronger solution, a dentist can prescribe Chlorhexidine Gluconate rinse. Use Medfinder to locate Cepacol Antibacterial Mouthwash in stock near you.