What Is Aptensio XR?

Aptensio XR is a brand-name, extended-release capsule containing Methylphenidate Hydrochloride, a central nervous system (CNS) stimulant used to treat Attention Deficit Hyperactivity Disorder (ADHD) in patients aged 6 years and older.

It is manufactured by Rhodes Pharmaceuticals L.P. (a subsidiary of Purdue Pharma) and was approved by the FDA for the treatment of ADHD. Aptensio XR is classified as a Schedule II controlled substance due to its potential for abuse and dependence.

What Is Aptensio XR Used For?

Aptensio XR is FDA-approved for one indication:

• ADHD (Attention Deficit Hyperactivity Disorder) in patients aged 6 and older — including children, adolescents, and adults.

ADHD is a neurodevelopmental condition characterized by persistent patterns of inattention, hyperactivity, and impulsivity that interfere with daily functioning. Aptensio XR helps manage these symptoms by increasing the availability of dopamine and norepinephrine in the brain.

Some doctors may also prescribe Methylphenidate off-label for conditions like narcolepsy or treatment-resistant depression, though Aptensio XR specifically is primarily used for ADHD.

For a deeper explanation of how it works, see our article on Aptensio XR's mechanism of action.

How Is Aptensio XR Taken?

Aptensio XR is taken once daily in the morning, with or without food. Here are the key details:

• Swallow the capsule whole, or open it and sprinkle the beads onto a spoonful of applesauce. Swallow the applesauce immediately — do not chew or crush the beads, as this would destroy the extended-release mechanism.
• Do not take in the afternoon or evening — this can cause insomnia.
• Available strengths: 10 mg, 15 mg, 20 mg, 25 mg, 30 mg, 35 mg, 40 mg, 50 mg, and 60 mg.
• Starting dose: Typically 10 mg once daily, with increases of 10 mg per week as needed. The maximum recommended dose is 60 mg per day.

Aptensio XR uses multilayer bead technology to deliver an initial dose quickly, followed by a gradual release over the rest of the day. Most patients experience symptom relief for approximately 10-12 hours.

Who Should Not Take Aptensio XR?

Aptensio XR is not appropriate for everyone. You should not take it if you have:

• A known allergy to methylphenidate or any ingredients in the capsule
• Glaucoma
• Motor tics or Tourette's syndrome (or a family history of Tourette's)
• Currently taking or recently stopped an MAO inhibitor — you must wait at least 14 days after stopping an MAOI before starting Aptensio XR

Use with caution if you have:

• Heart problems, high blood pressure, or a family history of sudden cardiac death
• A history of psychiatric disorders (psychosis, bipolar disorder, depression)
• A seizure disorder
• A history of substance abuse

Your doctor will evaluate your medical history before prescribing. For a complete list of potential interactions, see our drug interactions guide.

What Are the Side Effects?

Like all stimulant medications, Aptensio XR has potential side effects. The most common include:

• Decreased appetite and weight loss
• Insomnia
• Headache
• Nausea and stomach pain
• Dry mouth
• Irritability and anxiety

Serious side effects are less common but include cardiovascular events (increased heart rate and blood pressure), psychiatric symptoms (hallucinations, mania), and peripheral vasculopathy. Aptensio XR also carries an FDA boxed warning about its potential for abuse and dependence.

For a detailed breakdown, read our full guide on Aptensio XR side effects.

How Much Does Aptensio XR Cost?

Cost depends on whether you're filling brand-name or generic, and whether you have insurance:

• Brand-name Aptensio XR: $250 to $450 per month without insurance, depending on dose and pharmacy.
• Generic Methylphenidate ER capsules: $80 to $200 per month, depending on strength and pharmacy.

Insurance coverage varies widely. Many plans prefer generic methylphenidate formulations or Concerta, and may require prior authorization or step therapy before covering brand-name Aptensio XR.

Ways to save:

• Manufacturer savings program: Rhodes Pharmaceuticals has offered co-pay savings cards for commercially insured patients. Check aptensioxr.com for current offers.
• Discount cards: GoodRx, SingleCare, and other discount programs can reduce the cash price significantly.
• Patient assistance programs: Uninsured or underinsured patients may qualify for help through NeedyMeds.org or RxAssist.org.

For a comprehensive look at all savings options, see our guide to saving money on Aptensio XR.

Is a Generic Available?

Yes. Generic methylphenidate extended-release capsules are available and are typically much cheaper than brand-name Aptensio XR. However, different generic formulations may use different release mechanisms, so switching between brands may affect how the medication works for you. Talk to your doctor if you notice any changes after switching.

How Does Aptensio XR Compare to Other ADHD Medications?

Aptensio XR is one of several extended-release methylphenidate formulations on the market. Here's how it compares:

• Concerta — Uses OROS osmotic technology. Tablet form (cannot be opened). Lasts about 12 hours.
• Ritalin LA — Similar bead-based capsule. Can be opened and sprinkled. Lasts about 8 hours.
• Adderall XR — Contains mixed amphetamine salts (a different stimulant class). Lasts about 10-12 hours.
• Vyvanse — A prodrug (Lisdexamfetamine) with lower abuse potential. Lasts about 12-14 hours.

The best medication depends on your individual response, side effect profile, and insurance coverage. For more options, see our alternatives to Aptensio XR.

Final Thoughts

Aptensio XR is a well-established, once-daily ADHD medication with a flexible dosing range and the convenience of being sprinkled on food if you can't swallow capsules. Whether you're newly diagnosed or considering a switch from another medication, understanding how it works, what it costs, and what to expect can help you make an informed decision with your doctor.

If you need help finding Aptensio XR at a pharmacy near you, Medfinder can show you which pharmacies have it in stock right now.