Trintellix Shortage Update: 2026

If you take Trintellix (Vortioxetine) for depression, you may have heard about supply issues or experienced difficulty filling your prescription. This post gives you the latest information on Trintellix availability in 2026 and practical advice for navigating the situation.

Current Shortage Status

As of early 2026, Trintellix is not listed as an official shortage on the FDA's drug shortage database. However, many patients across the United States report localized supply problems — meaning some pharmacies have it and others don't. This is sometimes called a "soft shortage" or "spot shortage."

These localized shortages can be just as disruptive as an official shortage. If your pharmacy doesn't have your medication, it doesn't matter much whether the FDA calls it a shortage or not. The impact on your treatment is the same.

Why Is Trintellix in Short Supply?

Several factors contribute to Trintellix supply issues:

• Single manufacturer: Trintellix has no generic version. Only Takeda/Lundbeck produces it, so any production disruption affects the entire supply.
• Growing demand: More prescribers are choosing Trintellix for patients who need its unique multimodal mechanism, especially those with cognitive symptoms of depression.
• Distribution patterns: Pharmaceutical wholesalers allocate medications based on historical ordering patterns. Pharmacies that don't usually stock Trintellix may have trouble getting it when a new patient needs it.
• Insurance-driven pharmacy switching: When patients switch pharmacies due to insurance changes, the new pharmacy may not have Trintellix on hand.

For a deeper explanation, read our post on why Trintellix is so hard to find.

How This Affects Your Treatment

Gaps in your Trintellix supply can be more than an inconvenience — they can affect your mental health. Missing doses of an antidepressant may lead to:

• Return of depression symptoms
• Discontinuation symptoms (dizziness, irritability, nausea, "brain zaps")
• Anxiety about when you'll be able to get your next refill
• Disruption to your daily routine and work

That's why it's important to plan ahead and know your options.

What You Can Do Right Now

1. Check availability online

Use MedFinder to search for pharmacies near you that currently have Trintellix in stock. This can save you hours of phone calls. See our step-by-step guide: How to find Trintellix in stock near you.

2. Start refills early

Don't wait until your last pill to request a refill. Begin the process at least 7–10 days before you run out. This gives you a buffer to find the medication if your usual pharmacy is temporarily out.

3. Consider multiple pharmacies

Having a relationship with more than one pharmacy can help. Independent pharmacies, grocery store pharmacies, and mail-order services may have stock when chain pharmacies don't. Learn more in our guide on how to check if a pharmacy has Trintellix.

4. Talk to your doctor about a backup plan

Ask your prescriber what to do if you can't find Trintellix for several days. They may:

• Recommend a temporary alternative medication
• Provide samples to bridge a gap
• Adjust your dose to stretch your remaining supply (only under medical supervision)

If you're interested in alternatives, read our guide on alternatives to Trintellix.

5. Look into savings programs

If cost is part of the problem, there are programs that can help reduce what you pay for Trintellix. The manufacturer offers a savings card, and patient assistance programs exist for those who qualify. Read our full breakdown: How to save money on Trintellix in 2026.

Will a Generic Be Available Soon?

As of early 2026, there is no FDA-approved generic version of Trintellix (Vortioxetine). Patent protection is expected to last through approximately 2027–2029, depending on patent litigation outcomes. Once a generic becomes available, supply issues should improve significantly as multiple manufacturers enter the market.

How to Stay Informed

To stay up to date on Trintellix availability:

• Bookmark MedFinder and check regularly
• Sign up for FDA drug shortage alerts at FDA Drug Shortages
• Ask your pharmacist to notify you when new stock arrives
• Follow your prescriber's office for updates on medication availability

The Bottom Line

While Trintellix isn't in an official nationwide shortage, many patients are experiencing real difficulty finding it. By planning ahead, using tools like MedFinder, and keeping an open line of communication with your doctor, you can minimize disruptions to your treatment. Stay proactive, start refills early, and always have a backup plan.