Trintellix costs $450–$550/month without insurance. Learn how to save with manufacturer coupons, discount cards, and patient assistance programs.
Trintellix (Vortioxetine) is an effective antidepressant, but it comes with a high price tag. Without insurance, a 30-day supply can cost between $450 and $550. Since there's no generic version available yet, you can't simply switch to a cheaper generic to save money. But there are real ways to reduce what you pay. This guide covers every option available in 2026.
Trintellix is a brand-name medication manufactured by Takeda Pharmaceuticals in partnership with Lundbeck. It's still under patent protection, which means no other company can make a generic version. Without generic competition to drive prices down, the cost remains high. For more background, see our post on why Trintellix is so hard to find.
Takeda offers an official savings card for Trintellix. This is often the best deal available for patients with commercial insurance.
How it works:
Who qualifies:
This should be your first stop if you have private insurance. Many patients end up paying $10 or less per month.
If you don't have insurance — or your insurance doesn't cover Trintellix — prescription discount cards can reduce the cash price. These are free to use and accepted at most pharmacies.
Popular discount cards for Trintellix:
Important note: Discount cards typically work best for generic medications. For a brand-name drug like Trintellix, the savings may be modest (10–20% off cash price). Still worth checking — prices vary significantly between pharmacies.
If you're uninsured, underinsured, or have a low income, patient assistance programs can provide Trintellix for free or at a very low cost.
Takeda offers a patient assistance program for eligible patients who cannot afford their medications.
If your insurance does cover Trintellix but the copay is high, there are strategies to reduce your out-of-pocket cost:
Many plans require prior authorization for Trintellix. Make sure your doctor submits the PA request with documentation of previous medication trials. If you've tried and failed generic SSRIs like Escitalopram or Sertraline, this strengthens your case for approval.
If your insurance denies coverage, you have the right to appeal. Your doctor can submit a letter of medical necessity explaining why Trintellix is the best option for you. Common reasons include:
Trintellix is typically on Tier 3 (preferred brand) or non-preferred brand tier. During open enrollment, compare plans to find one that covers Trintellix at a lower tier or copay.
You can often stack the Trintellix Savings Card on top of your insurance copay. For example, if your insurance copay is $75, the savings card might reduce it to $10.
Where you fill your prescription matters:
Also check MedFinder to find pharmacies that have Trintellix in stock — there's no savings if the pharmacy doesn't have your medication. See our guide on how to find Trintellix near you.
If you simply can't afford Trintellix even with assistance, generic antidepressants may be a viable option. Generic SSRIs like Escitalopram and Sertraline cost as little as $4–$15 per month. While they don't have the same multimodal mechanism as Trintellix, they're effective for many patients with depression.
Talk to your doctor about whether an alternative might work for you. Read our full comparison in alternatives to Trintellix.
As of early 2026, there is no FDA-approved generic version of Trintellix (Vortioxetine). Patent protection is expected to last until approximately 2027–2029. Once a generic becomes available, prices could drop by 80% or more, as is typical with generic antidepressants. Until then, the strategies above are your best options for managing the cost.
Trintellix is expensive, but most patients can find a way to make it affordable. Start with the manufacturer savings card if you have commercial insurance. If you're uninsured, apply for the Takeda patient assistance program. And always compare pharmacy prices — a few minutes of research can save you hundreds of dollars per month. Use MedFinder to find Trintellix in stock near you, and talk to your doctor about the best savings strategy for your situation.
You focus on staying healthy. We'll handle the rest.
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