Prednisolone in 2026: Where Do Things Stand?

If you've had trouble finding Prednisolone at your pharmacy recently, you're part of a pattern that's been affecting patients for years. Prednisolone — a widely used corticosteroid prescribed for everything from childhood asthma to autoimmune diseases — has experienced recurring supply disruptions since 2020, with the oral liquid formulation being hit hardest.

Here's what patients need to know about the Prednisolone supply situation in 2026.

Is Prednisolone Still in Shortage?

As of early 2026, Prednisolone oral solution availability remains inconsistent. The situation has improved somewhat compared to the worst periods of 2022-2023, but supply is not fully stable. Here's the breakdown by formulation:

• Prednisolone oral solution (15 mg/5 mL): This is the formulation most frequently affected by shortages. It's the go-to liquid steroid for children and patients who can't swallow tablets. Availability varies significantly by region and pharmacy.
• Prednisolone oral solution (5 mg/5 mL): Generally more available than the 15 mg/5 mL concentration, though spot shortages still occur.
• Prednisolone tablets (5 mg): Tablets have been less affected by shortages and are usually available at most pharmacies.
• Orapred ODT (orally disintegrating tablets): Brand-name ODT has had its own supply issues and remains expensive ($200-$600+).

The FDA Drug Shortage Database has listed Prednisolone sodium phosphate oral solution periodically, and while some listings have been resolved, new disruptions continue to appear.

Why Is Prednisolone Hard to Find?

The same factors that created the initial shortages continue to play a role:

• Few manufacturers: Only a handful of companies make generic Prednisolone liquid. When one has a production issue, the others can't easily absorb the demand.
• Seasonal demand: Fall and winter bring respiratory illness surges — croup, asthma flares, bronchiolitis — that spike demand for pediatric Prednisolone liquid.
• Supply chain fragility: Raw material sourcing, manufacturing complexity for liquid formulations, and shipping logistics all contribute to an unreliable pipeline.
• Low profitability: Generic Prednisolone liquid sells for relatively little, which discourages new manufacturers from entering the market.

For a deeper dive into these issues, see why Prednisolone is so hard to find in 2026.

What Does Prednisolone Cost in 2026?

Cost hasn't changed dramatically, but here's what patients can expect:

• Generic Prednisolone oral solution: $10-$50 for a typical course (without insurance)
• Generic Prednisolone tablets: $5-$20 for a short course
• Orapred ODT (brand): $200-$600+ without insurance
• Compounded Prednisolone liquid: $30-$80 (if you go the compounding pharmacy route during shortages)

Most insurance plans cover generic Prednisolone as a Tier 1 preferred generic, meaning low copays — often $0 to $10. Brand-name formulations may require prior authorization. For detailed savings strategies, read our guide on how to save money on Prednisolone.

Are There New Options for Patients in 2026?

While no brand-new Prednisolone formulations have launched, there are a few developments worth noting:

• Compounding pharmacies have become more widely used for Prednisolone liquid during shortages. Many now routinely stock the ingredients needed to prepare it on demand.
• Dexamethasone oral solution has become a more commonly accepted alternative for pediatric use, with updated clinical guidance supporting single-dose or short-course regimens for croup and some asthma flares.
• Telehealth prescribing has made it easier to get alternative prescriptions quickly when your original Prednisolone script can't be filled. Many telehealth platforms can prescribe corticosteroids and send prescriptions to whichever pharmacy has stock.

How to Find Prednisolone in Stock Right Now

If you need Prednisolone today, here's your action plan:

1. Search on Medfinder — Check real-time pharmacy availability in your area. This is the fastest way to find which pharmacies currently have Prednisolone.
2. Call independent pharmacies — They often use different wholesalers than the chains and may have stock when CVS and Walgreens don't.
3. Ask about compounding — If commercially manufactured Prednisolone liquid is unavailable, a compounding pharmacy can prepare it. Your doctor needs to write a compounding prescription.
4. Discuss alternatives with your doctor — Alternatives like Prednisone, Dexamethasone, or Methylprednisolone may work for your condition.
5. Check different concentrations — If the 15 mg/5 mL isn't available, ask your pharmacist and doctor about the 5 mg/5 mL (you'd take a larger volume for the same dose).

For more detailed tips, see our guide on how to find Prednisolone in stock near you.

Final Thoughts

The Prednisolone shortage story in 2026 is one of gradual but incomplete improvement. Supply is better than it was at the worst points, but it's still unreliable enough that patients regularly face empty shelves — especially for the liquid formulation.

The best thing you can do is stay informed, use tools like Medfinder to check availability proactively, and have a backup plan in place with your doctor. If you're on long-term Prednisolone, don't wait until your last dose to try to refill — give yourself a buffer to navigate any supply hiccups.

We'll continue updating this page as the supply situation evolves. For provider-specific information, see our Prednisolone shortage guide for providers and prescribers.